Search Results - "Habu, Kiyoshi"

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases by Fukuzawa, Taku, Sampei, Zenjiro, Haraya, Kenta, Ruike, Yoshinao, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Gan, Siok Wan, Irie, Machiko, Tsuboi, Yoshinori, Tai, Hitoshi, Sakiyama, Tetsushi, Sakamoto, Akihisa, Ishii, Shinya, Maeda, Atsuhiko, Iwayanagi, Yuki, Shibahara, Norihito, Shibuya, Mitsuko, Nakamura, Genki, Nambu, Takeru, Hayasaka, Akira, Mimoto, Futa, Okura, Yuu, Hori, Yuji, Habu, Kiyoshi, Wada, Manabu, Miura, Takaaki, Tachibana, Tatsuhiko, Honda, Kiyofumi, Tsunoda, Hiroyuki, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi

“…Dysregulation of the complement system is linked to the pathogenesis of a variety of hematological disorders. Eculizumab, an anti-complement C5 monoclonal…”
Get full text

A defucosylated anti‐CD317 antibody exhibited enhanced antibody‐dependent cellular cytotoxicity against primary myeloma cells in the presence of effectors from patients by Ishiguro, Takahiro, Kawai, Shigeto, Habu, Kiyoshi, Sugimoto, Masamichi, Shiraiwa, Hirotake, Iijima, Shigeyuki, Ozaki, Shuji, Matsumoto, Toshio, Yamada‐Okabe, Hisafumi

“…The humanized monoclonal antibody (mAb) against CD317 antigen (anti‐HM1.24 antibody; AHM), which is highly expressed on multiple myeloma (MM), induces…”
Get full text

Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization by Nakano, Kiyotaka, Ishiguro, Takahiro, Konishi, Hiroko, Tanaka, Megumi, Sugimoto, Masamichi, Sugo, Izumi, Igawa, Tomoyuki, Tsunoda, Hiroyuki, Kinoshita, Yasuko, Habu, Kiyoshi, Orita, Tetsuro, Tsuchiya, Masayuki, Hattori, Kunihiro, Yamada-Okabe, Hisafumi

“…Glypican 3 (GPC3), a glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan, is expressed in a majority of hepatocellular carcinoma tissues. The…”
Get full text

Role of Lkb1, The Causative Gene of Peutz-Jegher's Syndrome, in Embryogenesis and Polyposis by Jishage, Kou-ichi, Nezu, Jun-ichi, Kawase, Yosuke, Iwata, Takamitsu, Watanabe, Miho, Miyoshi, Akio, Ose, Asuka, Habu, Kiyoshi, Kake, Takei, Kamada, Nobuo, Ueda, Otoya, Kinoshita, Michiko, Jenne, Dieter E., Shimane, Miyuki, Suzuki, Hiroshi

“…Peutz-Jeghers syndrome (PJS) is a dominantly inherited human disorder characterized by gastrointestinal hamartomatous polyposis and mucocutaneous melanin…”
Get full text

Anti-GPRC5D/CD3 Bispecific T-Cell-Redirecting Antibody for the Treatment of Multiple Myeloma by Kodama, Tatsushi, Kochi, Yu, Nakai, Waka, Mizuno, Hideaki, Baba, Takeshi, Habu, Kiyoshi, Sawada, Noriaki, Tsunoda, Hiroyuki, Shima, Takahiro, Miyawaki, Kohta, Kikushige, Yoshikane, Mori, Yasuo, Miyamoto, Toshihiro, Maeda, Takahiro, Akashi, Koichi

“…Although treatment advances over recent decades have significantly improved survival of patients with multiple myeloma, there is still an unmet medical need…”
Get full text

Abstract 1886: Anti -GPRC5D/CD3 T cell-redirecting bispecific antibody with potent in vitro and in vivo antitumor efficacy against multiple myeloma by Kodama, Tatsushi, Kochi, Yu, Nakai, Waka, Mizuno, Hideaki, Baba, Takeshi, Habu, Kiyoshi, Sawada, Noriaki, Tsunoda, Hiroyuki, Shima, Takahiro, Miyawaki, Kohta, Kikushige, Yoshikane, Mori, Yasuo, Miyamoto, Toshihiro, Maeda, Takahiro, Akashi, Koichi

“…Abstract Background: Although treatment advances over recent decades have significantly improved survival of patients with multiple myeloma, there is still an…”
Get full text

Overexpression of theDel1 gene causes dendritic branching in the mouse mesentery by Hidai, Chiaki, Kawana, Masatoshi, Habu, Kiyoshi, Kazama, Hiromi, Kawase, Yosuke, Iwata, Takamitsu, Suzuki, Hiroshi, Quertermous, Thomas, Kokubun, Shinichiro

Get full text

The Human T Cell Leukemia Virus Type I-tax Gene Is Responsible for the Development of Both Inflammatory Polyarthropathy Resembling Rheumatoid Arthritis and Noninflammatory Ankylotic Arthropathy in Transgenic Mice by Habu, Kiyoshi, Nakayama-Yamada, Junko, Asano, Masahide, Saijo, Shinobu, Itagaki, Keiko, Horai, Reiko, Yamamoto, Hiroaki, Sekiguchi, Toyozo, Nosaka, Tetsuya, Hatanaka, Masakazu, Iwakura, Yoichiro

“…We previously reported that inflammatory arthropathy resembling rheumatoid arthritis (RA) develops among transgenic mice carrying the long terminal repeat…”
Get full text

Bone Marrow-Derived Cells Are Responsible for the Development of Autoimmune Arthritis in Human T Cell Leukemia Virus Type I-Transgenic Mice and Those of Normal Mice Can Suppress the Disease by Saijo, Shinobu, Kotani, Motoko, Habu, Kiyoshi, Ishitsuka, Chiho, Yamamoto, Hiroaki, Sekiguchi, Toyozo, Iwakura, Yoichiro

“…Previously, we reported that human T cell leukemia virus type I env-pX region-introduced transgenic (pX-Tg) mice developed an inflammatory polyarthropathy…”
Get full text

Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery by Hidai, Chiaki, Kawana, Masatoshi, Habu, Kiyoshi, Kazama, Hiromi, Kawase, Yosuke, Iwata, Takamitsu, Suzuki, Hiroshi, Quertermous, Thomas, Kokubun, Shinichiro

“…In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular…”
Get full text