Search Results - "Habrian, Chris"

Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation by Vyklicky, Vojtech, Stanley, Cherise, Habrian, Chris, Isacoff, Ehud Y.

“…N-Methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for synaptic plasticity and memory. Receptor activation involves glycine-…”
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Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors by Levitz, Joshua, Habrian, Chris, Bharill, Shashank, Fu, Zhu, Vafabakhsh, Reza, Isacoff, Ehud Y.

“…G protein-coupled receptors (GPCRs) mediate cellular responses to a wide variety of extracellular stimuli. GPCR dimerization may expand signaling diversity and…”
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Conformational pathway provides unique sensitivity to a synaptic mGluR by Habrian, Chris H., Levitz, Joshua, Vyklicky, Vojtech, Fu, Zhu, Hoagland, Adam, McCort-Tranchepain, Isabelle, Acher, Francine, Isacoff, Ehud Y.

“…Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at synapses. Macroscopic and single molecule FRET to monitor…”
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Homo- and hetero-dimeric subunit interactions set affinity and efficacy in metabotropic glutamate receptors by Habrian, Chris, Latorraca, Naomi, Fu, Zhu, Isacoff, Ehud Y.

“…Metabotropic glutamate receptors (mGluRs) are dimeric class C G-protein–coupled receptors that operate in glia and neurons. Glutamate affinity and efficacy…”
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Negative allosteric modulation of the glucagon receptor by RAMP2 by Krishna Kumar, Kaavya, O’Brien, Evan S., Habrian, Chris H., Latorraca, Naomi R., Wang, Haoqing, Tuneew, Inga, Montabana, Elizabeth, Marqusee, Susan, Hilger, Daniel, Isacoff, Ehud Y., Mathiesen, Jesper Mosolff, Kobilka, Brian K.

“…Receptor activity-modifying proteins (RAMPs) modulate the activity of many Family B GPCRs. We show that RAMP2 directly interacts with the glucagon receptor…”
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Quantitative analysis of TALE-DNA interactions suggests polarity effects by Meckler, Joshua F, Bhakta, Mital S, Kim, Moon-Soo, Ovadia, Robert, Habrian, Chris H, Zykovich, Artem, Yu, Abigail, Lockwood, Sarah H, Morbitzer, Robert, Elsäesser, Janett, Lahaye, Thomas, Segal, David J, Baldwin, Enoch P

“…Transcription activator-like effectors (TALEs) have revolutionized the field of genome engineering. We present here a systematic assessment of TALE DNA…”
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Subtype-specific conformational landscape of NMDA receptor gating by Bleier, Julia, Furtado de Mendonca, Philipe Ribeiro, Habrian, Chris H., Stanley, Cherise, Vyklicky, Vojtech, Isacoff, Ehud Y.

“…N-methyl-D-aspartate receptors are ionotropic glutamate receptors that mediate synaptic transmission and plasticity. Variable GluN2 subunits in…”
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Large-scale filament formation inhibits the activity of CTP synthetase by Barry, Rachael M, Bitbol, Anne-Florence, Lorestani, Alexander, Charles, Emeric J, Habrian, Chris H, Hansen, Jesse M, Li, Hsin-Jung, Baldwin, Enoch P, Wingreen, Ned S, Kollman, Justin M, Gitai, Zemer

“…CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous…”
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Unique Conformational Dynamics and Dimer Tuning of mGluR7 by Habrian, Chris

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Author Correction: Stepwise activation of a metabotropic glutamate receptor by Krishna Kumar, Kaavya, Wang, Haoqing, Habrian, Chris, Latorraca, Naomi R., Xu, Jun, O’Brien, Evan S., Zhang, Chensong, Montabana, Elizabeth, Koehl, Antoine, Marqusee, Susan, Isacoff, Ehud Y., Kobilka, Brian K.

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Stepwise activation of a metabotropic glutamate receptor by Krishna Kumar, Kaavya, Wang, Haoqing, Habrian, Chris, Latorraca, Naomi R., Xu, Jun, O’Brien, Evan S., Zhang, Chensong, Montabana, Elizabeth, Koehl, Antoine, Marqusee, Susan, Isacoff, Ehud Y., Kobilka, Brian K.

“…Metabotropic glutamate receptors belong to a family of G protein-coupled receptors that are obligate dimers and possess a large extracellular ligand-binding…”
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Negative allosteric modulation of the glucagon receptor by RAMP2 by O'Brien, Evan S., Krishna Kumar, Kaavya, Habrian, Chris, Latorraca, Naomi R., Wang, Haoqing, Tuneew, Inga, Montabana, Elizabeth, Marqusee, Susan, Hilger, Daniel, Isacoff, Ehud Y., Mathiesen, Jesper M., Kobilka, Brian K.

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Inhibition of Escherichia coli CTP Synthetase by NADH and Other Nicotinamides and Their Mutual Interactions with CTP and GTP by Habrian, Chris, Chandrasekhara, Adithi, Shahrvini, Bita, Hua, Brian, Lee, Jason, Jesinghaus, Roger, Barry, Rachael, Gitai, Zemer, Kollman, Justin, Baldwin, Enoch P

“…CTP synthetases catalyze the last step of pyrimidine biosynthesis and provide the sole de novo source of cytosine-containing nucleotides. As a central…”
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Mechanism of Activation and Modulation of Homomeric and Heteromeric Metabotropic Glutamate Receptors by Habrian, Chris H

“…Synaptic plasticity underlies all learning and memory and is a cornerstone of neurological function. The adaptive and flexible nature of these processes makes…”
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Optical Probing of Metabotropic Glutamate Receptors by Levitz, Josh, Habrian, Chris, Bharill, Shashank, Fu, Zhu, Vafabakhsh, Reza, Isacoff, Ehud

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