Search Results - "Habjan, Eva"

An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor by Habjan, Eva, Ho, Vien Q T, Gallant, James, van Stempvoort, Gunny, Jim, Kin Ki, Kuijl, Coen, Geerke, Daan P, Bitter, Wilbert, Speer, Alexander

“…Finding new anti-tuberculosis compounds with convincing in vivo activity is an ongoing global challenge to fight the emergence of multidrug-resistant…”
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Dysregulation of Mycobacterium marinum ESX-5 Secretion by Novel 1,2,4-oxadiazoles by Ho, Vien Q T, Rong, Mark K, Habjan, Eva, Bommer, Samantha D, Pham, Thang V, Piersma, Sander R, Bitter, Wilbert, Ruijter, Eelco, Speer, Alexander

“…The ESX-5 secretion system is essential for the viability and virulence of slow-growing pathogenic mycobacterial species. In this study, we identified a…”
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Diving into drug-screening: zebrafish embryos as an in vivo platform for antimicrobial drug discovery and assessment by Habjan, Eva, Schouten, Gina K, Speer, Alexander, van Ulsen, Peter, Bitter, Wilbert

“…The rise of multidrug-resistant bacteria underlines the need for innovative treatments, yet the introduction of new drugs has stagnated despite numerous…”
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Heterologous Expression of ethA and katG in Mycobacterium marinum Enables the Rapid Identification of New Prodrugs Active against Mycobacterium tuberculosis by Ho, Vien Q T, Verboom, Theo, Rong, Mark K, Habjan, Eva, Bitter, Wilbert, Speer, Alexander

“…Screening strategies for antituberculosis compounds using are time consuming and require biosafety level 3 (BSL3) facilities, which makes the development of…”
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Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteria by Sterle, Maša, Habjan, Eva, Piga, Martina, Peršolja, Peter, Durcik, Martina, Dernovšek, Jaka, Szili, Petra, Czikkely, Marton Simon, Zidar, Nace, Janez, Ilaš, Pal, Csaba, Accetto, Tomaž, Pardo, Luis A., Kikelj, Danijel, Peterlin Mašič, Lucija, Tomašič, Tihomir, Bitter, Wilbert, Cotman, Andrej Emanuel, Speer, Alexander, Zega, Anamarija

“…New 2-pyrrolamidobenzothiazole-based inhibitors of mycobacterial DNA gyrase were discovered. Among these, compounds 49 and 51, show excellent antibacterial…”
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Modulating mycobacterial envelope integrity for antibiotic synergy with benzothiazoles by Habjan, Eva, Lepioshkin, Alexander, Charitou, Vicky, Egorova, Anna, Kazakova, Elena, Ho, Vien QT, Bitter, Wilbert, Makarov, Vadim, Speer, Alexander

“…Developing effective tuberculosis drugs is hindered by mycobacteria's intrinsic antibiotic resistance because of their impermeable cell envelope. Using…”
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Dysregulation of IMycobacterium marinum/I ESX-5 Secretion by Novel 1,2,4-oxadiazoles by Ho, Vien Q. T, Rong, Mark K, Habjan, Eva, Bommer, Samantha D, Pham, Thang V, Piersma, Sander R, Bitter, Wilbert, Ruijter, Eelco, Speer, Alexander

“…The ESX-5 secretion system is essential for the viability and virulence of slow-growing pathogenic mycobacterial species. In this study, we identified a…”
Get full text