Antidiabetic effect of oral supplementation with Caulerpa racemosa powder

Antidiabetic effect of oral supplementation with Caulerpa racemosa powder

Algae are known for their high nutritional value and the presence of bioactive compounds with anti-diabetic activity. In this study, the effects of oral supplementation with the whole powdered green alga Caulerpa racemosa was assessed on biochemical and organic parameters in rat model of type 2 diab...

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Bibliographic Details
Published in:European Journal of Biological Research Vol. 12; no. 2; pp. 141 - 152
Main Authors: Habitri, Nassima El, Belkacemi, Louiza
Format: Journal Article
Language:English
Published: Poznan European Journal of Biological Research 01-05-2022
TMKarpinski Publisher, Tomasz M. Karpiński
Subjects:
Algae
Bioactive compounds
Blood glucose
Body weight
Caulerpa racemosa
Diabetes
Diabetes mellitus (non-insulin dependent)
Dietary supplements
Fasting
Glucose tolerance
High fat diet
Histopathology
IPGTT
Laboratory testing
Lipid peroxidation
Liver
Metabolic disorders
Nutritive value
Oral supplementation
Streptozocin
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Summary:Algae are known for their high nutritional value and the presence of bioactive compounds with anti-diabetic activity. In this study, the effects of oral supplementation with the whole powdered green alga Caulerpa racemosa was assessed on biochemical and organic parameters in rat model of type 2 diabetes. Type 2 diabetes model (DM) was induced by high fat diet (HFD) (5.75 kcal/g) combined to streptozotocin injection (35 mg/kg). The DM-C500 and DM-C1000 groups were maintained on HFD and supplemented orally during four weeks with powdered C. racemosa at 500 and 1000 mg/kg of body weight, respectively. The DM-C0 group was fed with HFD without C. racemosa supplementation. All the experimental rats were maintained on HFD during the 30 days of experiment. C. racemosa at 500 mg/kg improved fasting glycaemia and glucose tolerance. The IPGTT test revealed a decrease (p<0.05) in the fasting glycaemia recorded at the 120th min from day 0 (534 ± 38.88 mg/dL) to day 30 (326 ± 63.05 mg/dL). C. racemosa supplementation prevented liver lipid peroxidation in DM-C500 and DM-C1000 group (12.94 ± 2.20 and 10.48 ± 1.15 nmol MDA/g, respectively) compared to DM-C0 group (35.49 ± 2.30 nmol MDA/g). Caulerpa racemosa at 500 mg/kg, and relatively at 1000 mg/kg, alleviated pancreatic, liver and renal tissue damages compared to DM-C0 groups which displayed injuries in their histological sections. Caulerpa racemosa oral supplementation could represent a possible natural approach to prevent organic and metabolic disorders related to type 2 diabetes.
ISSN:2449-8955
DOI:10.5281/zenodo.6560521