Search Results - "Habisch, Hansjoerg"
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The sex-specific metabolic signature of C57BL/6NRj mice during aging
Published in Scientific reports (06-12-2022)“…Due to intact reactive oxygen species homeostasis and glucose metabolism, C57BL/6NRj mice are especially suitable to study cellular alterations in metabolism…”
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2
Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice
Published in Molecular metabolism (Germany) (01-01-2024)“…Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the…”
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3
Efficacy and Safety of Intermittent Fasting in People With Insulin-Treated Type 2 Diabetes (INTERFAST-2)-A Randomized Controlled Trial
Published in Diabetes care (01-02-2023)“…To investigate the safety and feasibility of 3 nonconsecutive days of intermittent fasting (IF) per week over 12 weeks in participants with insulin-treated…”
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4
Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD
Published in Journal of lipid research (01-09-2024)“…Chronic kidney disease (CKD) is often associated with decreased activity of lecithin-cholesterol acyltransferase (LCAT), an enzyme essential for HDL…”
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5
Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health
Published in Molecules (Basel, Switzerland) (25-07-2022)“…Lipoproteins are important cardiovascular (CV) risk biomarkers. This study aimed to investigate the associations of lipoprotein subclasses with micro- and…”
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Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome
Published in International journal of molecular sciences (01-05-2024)“…Metabolic syndrome (MS) is a widespread disease in developed countries, accompanied, among others, by decreased adiponectin serum levels and perturbed…”
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Altered gut microbiome, bile acid composition and metabolome in sarcopenia in liver cirrhosis
Published in Journal of cachexia, sarcopenia and muscle (01-12-2023)“…Background Sarcopenia in liver cirrhosis is associated with low quality of life and high mortality risk. The pathogenesis has yet to be fully understood. We…”
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Associations between Endothelial Lipase and Apolipoprotein B-Containing Lipoproteins Differ in Healthy Volunteers and Metabolic Syndrome Patients
Published in International journal of molecular sciences (26-06-2023)“…The association between serum levels of endothelial lipase (EL) and the serum levels and composition of apolipoprotein B (apoB)-containing lipoproteins in…”
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9
Spermidine is essential for fasting-mediated autophagy and longevity
Published in Nature cell biology (01-09-2024)“…Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine…”
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10
Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis
Published in The Journal of biological chemistry (01-09-2022)“…The tumor suppressor p53 is involved in the adaptation of hepatic metabolism to nutrient availability. Acute deletion of p53 in the mouse liver affects hepatic…”
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Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients
Published in International journal of molecular sciences (20-01-2023)“…Metabolic syndrome (MS) is characterized by endothelial- and high-density lipoprotein (HDL) dysfunction and increased endothelial lipase (EL) serum levels. We…”
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12
Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial
Published in Cardiovascular diabetology (12-09-2024)“…Cardiovascular disease represents a significant risk factor for mortality in individuals with type 2 diabetes mellitus (T2DM). High-density lipoprotein (HDL)…”
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13
Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia
Published in Biomedicine & pharmacotherapy (01-09-2024)“…Atherosclerosis, the leading cause of cardiovascular disease, cannot be sufficiently explained by established risk factors, including cholesterol. Elevated…”
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Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients
Published in Redox biology (01-10-2024)“…Acute heart failure (AHF) is typified by inflammatory and oxidative stress responses, which are associated with unfavorable patient outcomes. Given the…”
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Interindividual differences in aronia juice tolerability linked to gut microbiome and metabolome changes-secondary analysis of a randomized placebo-controlled parallel intervention trial
Published in Microbiome (09-03-2024)“…Aronia melanocarpa is a berry rich in polyphenols known for health benefits. However, the bioavailability of polyphenols has been questioned, and the…”
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16
Targeting epigenetic features in clear cell sarcomas based on patient-derived cell lines
Published in Journal of translational medicine (29-01-2023)“…Clear cell sarcomas (CCSs) are translocated aggressive malignancies, most commonly affecting young adults with a high incidence of metastases and a poor…”
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17
Reduced olfactory performance is associated with changed microbial diversity, oralization, and accumulation of dead biomaterial in the nasal olfactory area
Published in Microbiology spectrum (06-02-2024)“…The partial or complete loss of the sense of smell, which affects about 20% of the population, impairs the quality of life in many ways. Dysosmia and anosmia…”
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HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function
Published in Antioxidants (01-11-2023)“…COVID-19, caused by the SARS-CoV-2 coronavirus, emerged as a global pandemic in late 2019, resulting in significant global public health challenges. The…”
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Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome
Published in Antioxidants (01-03-2024)“…The association between advanced oxidation protein products (AOPPs) and lipoprotein subclasses remains unexplored. Therefore, we performed comprehensive…”
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HDL-apoA-II Is Strongly Associated with 1-Year Mortality in Acute Heart Failure Patients
Published in Biomedicines (11-07-2022)“…The prognostic value of the subset of high-density lipoprotein (HDL) particles containing apolipoprotein (apo)A-II (HDL-apoA-II) in acute heart failure (AHF)…”
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