Search Results - "Habich, Markus"

Stop wasting protein—Proteasome inhibition to target diseases linked to mitochondrial import by Habich, Markus, Riemer, Jan

“…Mitochondrial dysfunction is linked to various human diseases. Symptoms can occur early in life or manifest progressively during life and include poor muscle…”
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Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells by Fischer, Manuel, Horn, Sebastian, Belkacemi, Anouar, Kojer, Kerstin, Petrungaro, Carmelina, Habich, Markus, Ali, Muna, Küttner, Victoria, Bien, Melanie, Kauff, Frank, Dengjel, Jörn, Herrmann, Johannes M, Riemer, Jan

“…Oxidation of cysteine residues to disulfides drives import of many proteins into the intermembrane space of mitochondria. Recent studies in yeast unraveled the…”
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Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay by Habich, Markus, Salscheider, Silja Lucia, Murschall, Lena Maria, Hoehne, Michaela Nicole, Fischer, Manuel, Schorn, Fabian, Petrungaro, Carmelina, Ali, Muna, Erdogan, Alican J., Abou-Eid, Shadi, Kashkar, Hamid, Dengjel, Joern, Riemer, Jan

“…Disulfide formation in the mitochondrial intermembrane space (IMS) is an essential process. It is catalyzed by the disulfide relay machinery, which couples…”
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The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo by Erdogan, Alican J., Ali, Muna, Habich, Markus, Salscheider, Silja L., Schu, Laura, Petrungaro, Carmelina, Thomas, Luke W., Ashcroft, Margaret, Leichert, Lars I., Roma, Leticia Prates, Riemer, Jan

“…Disulfide formation in the mitochondrial intermembrane space is an essential process catalyzed by a disulfide relay machinery. In mammalian cells, the key…”
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Cysteine residues in mitochondrial intermembrane space proteins: more than just import by Habich, Markus, Salscheider, Silja Lucia, Riemer, Jan

“…The intermembrane space (IMS) is a very small mitochondrial sub‐compartment with critical relevance for many cellular processes. IMS proteins fulfil important…”
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Detection of Cysteine Redox States in Mitochondrial Proteins in Intact Mammalian Cells by Habich, Markus, Riemer, Jan

“…Import, folding, and activity regulation of mitochondrial proteins are important for mitochondrial function. Cysteine residues play crucial roles in these…”
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Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding by Döring, Kristina, Ahmed, Nabeel, Riemer, Trine, Suresh, Harsha Garadi, Vainshtein, Yevhen, Habich, Markus, Riemer, Jan, Mayer, Matthias P., O’Brien, Edward P., Kramer, Günter, Bukau, Bernd

“…The yeast Hsp70 chaperone Ssb interacts with ribosomes and nascent polypeptides to assist protein folding. To reveal its working principle, we determined the…”
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Lipid signalling drives proteolytic rewiring of mitochondria by YME1L by MacVicar, Thomas, Ohba, Yohsuke, Nolte, Hendrik, Mayer, Fiona Carola, Tatsuta, Takashi, Sprenger, Hans-Georg, Lindner, Barbara, Zhao, Yue, Li, Jiahui, Bruns, Christiane, Krüger, Marcus, Habich, Markus, Riemer, Jan, Schwarzer, Robin, Pasparakis, Manolis, Henschke, Sinika, Brüning, Jens C., Zamboni, Nicola, Langer, Thomas

“…Reprogramming of mitochondria provides cells with the metabolic flexibility required to adapt to various developmental transitions such as stem cell activation…”
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Proteasomal degradation induced by DPP9‐mediated processing competes with mitochondrial protein import by Finger, Yannik, Habich, Markus, Gerlich, Sarah, Urbanczyk, Sophia, van de Logt, Erik, Koch, Julian, Schu, Laura, Lapacz, Kim Jasmin, Ali, Muna, Petrungaro, Carmelina, Salscheider, Silja Lucia, Pichlo, Christian, Baumann, Ulrich, Mielenz, Dirk, Dengjel, Joern, Brachvogel, Bent, Hofmann, Kay, Riemer, Jan

“…Plasticity of the proteome is critical to adapt to varying conditions. Control of mitochondrial protein import contributes to this plasticity. Here, we…”
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AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5 by Salscheider, Silja Lucia, Gerlich, Sarah, Cabrera‐Orefice, Alfredo, Peker, Esra, Rothemann, Robin Alexander, Murschall, Lena Maria, Finger, Yannik, Szczepanowska, Karolina, Ahmadi, Zeinab Alsadat, Guerrero‐Castillo, Sergio, Erdogan, Alican, Becker, Mark, Ali, Muna, Habich, Markus, Petrungaro, Carmelina, Burdina, Nele, Schwarz, Guenter, Klußmann, Merlin, Neundorf, Ines, Stroud, David A, Ryan, Michael T, Trifunovic, Aleksandra, Brandt, Ulrich, Riemer, Jan

“…The mitochondrial intermembrane space protein AIFM1 has been reported to mediate the import of MIA40/CHCHD4, which forms the import receptor in the…”
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Abstract 1045: A freely expandable 20-plex immuno-oncology antibody core panel for spatial biology experiments on human FFPE cancer sections: REAplex IO Core for MICS technology by Femel, Julia, DiBasio, Eric C., Schönborn, Katrin, Büttner, Maximilian, Düking, Tim, Habich, Markus, Wantenaar, Tanya, Eulitz, Stefan, Bosio, Andreas

“…Abstract Spatial biology is integral to understanding the dynamics of immune cells, tumor microenvironment (TME), and therapeutic responses in cancer research…”
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