Search Results - "Habets, Kim L. L."

Platelets and autoimmunity by Habets, Kim L. L., Huizinga, Tom W. J., Toes, René E. M.

“…Vascular injury is the initial manifestation of inflammation resulting in the recruitment and activation of various cell types. The integrity of the vascular…”
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CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice by van Puijvelde, Gijs H M, Foks, Amanda C, van Bochove, Rosemarie E, Bot, Ilze, Habets, Kim L L, de Jager, Saskia C, Ter Borg, Mariëtte N D, van Osch, Puck, Boon, Louis, Vos, Mariska, de Waard, Vivian, Kuiper, Johan

“…An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta leading to serious complications and mostly to death. AAA development is associated…”
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Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1 by Meurs, Illiana, Calpe-Berdiel, Laura, Habets, Kim L L, Zhao, Ying, Korporaal, Suzanne J A, Mommaas, A Mieke, Josselin, Emmanuelle, Hildebrand, Reeni B, Ye, Dan, Out, Ruud, Kuiper, Johan, Van Berkel, Theo J C, Chimini, Giovanna, Van Eck, Miranda

“…ABCA7, a close relative of ABCA1 which facilitates cholesterol efflux to lipid-poor apoproteins, has been implicated in macrophage lipid efflux and clearance…”
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Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis by Habets, Kim L L, Trouw, Leendert A, Levarht, E W Nivine, Korporaal, Suzanne J A, Habets, Petra A M, de Groot, Philip, Huizinga, Tom W J, Toes, René E M

“…Although the role of platelets in rheumatoid arthritis (RA) is relatively unexplored, recent studies point towards a contribution of platelets in arthritis. We…”
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Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1β by Suurmond, Jolien, Habets, Kim L L, Dorjée, Annemarie L, Huizinga, Tom W, Toes, René E M

“…Mast cells (MC) are most well known for their role in innate immune responses. However, MC are increasingly recognized as important regulators of adaptive…”
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Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice by Habets, Kim L.L., van Puijvelde, Gijs H.M., van Duivenvoorde, Leonie M., van Wanrooij, Eva J.A., de Vos, Paula, Tervaert, Jan-Willem Cohen, van Berkel, Theo J.C., Toes, Rene E.M., Kuiper, Johan

“…Aims Modification of lipoproteins plays an important role in the development of atherosclerosis. Oxidatively modified low-density lipoprotein (oxLDL) has a…”
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Interruption of the OX40-OX40 ligand pathway in LDL receptor-deficient mice causes regression of atherosclerosis by Foks, Amanda C, van Puijvelde, Gijs H M, Bot, Ilze, ter Borg, Mariette N D, Habets, Kim L L, Johnson, Jason L, Yagita, Hideo, van Berkel, Theo J C, Kuiper, Johan

“…Patients suffering from cardiovascular disease have well-established atherosclerotic lesions, rendering lesion regression of therapeutic interest. The OX40…”
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Repeated FcεRI triggering reveals modified mast cell function related to chronic allergic responses in tissue by Suurmond, Jolien, MSc, Habets, Kim L.L., PhD, Tatum, Zuotian, MSc, Schonkeren, Joris J., BASc, Hoen, Peter A.C.'t, PhD, Huizinga, Tom W.J., MD, PhD, Laros, Jeroen F.J., PhD, Toes, René E.M., PhD, Kurreeman, Fina, PhD

“…Background Activation of mast cells through FcεRI plays an important role in acute allergic reactions. However, little is known about the function of mast…”
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Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells by Hillaert, Ulrik, Verdoes, Martijn, Florea, Bogdan I, Saragliadis, Anastasios, Habets, Kim L.L, Kuiper, Johan, Van Calenbergh, Serge, Ossendorp, Ferry, van der Marel, Gijsbert A, Driessen, Christoph, Overkleeft, Hermen S

“…Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake…”
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Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model by Jansen, Diahann T S L, el Bannoudi, Hanane, Arens, Ramon, Habets, Kim L L, Hameetman, Marjolijn, Huizinga, Tom W J, Stoop, Jeroen N, Toes, René E M

“…Abatacept is a fusion protein of human cytotoxic T-lymphocyte-associated protein (CTLA)-4 and the Fc portion of human immunoglobulin G1 (IgG1). It is believed…”
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Vaccination against TIE2 reduces atherosclerosis by Hauer, Arnaud D, Habets, Kim L.L, van Wanrooij, Eva J.A, de Vos, Paula, Krueger, Joerg, Reisfeld, Ralph A, van Berkel, Theo J.C, Kuiper, Johan

“…Abstract Background TIE2+ cells play a crucial role in processes that are involved in atherosclerosis, such as angiogenesis. Therefore, the specific deletion…”
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Leukocyte Bim deficiency does not impact atherogenesis in ldlr−/− mice, despite a pronounced induction of autoimmune inflammation by Temmerman, Lieve, Westra, Marijke M., Bot, Ilze, van Vlijmen, Bart J. M., van Bree, Niek, Bot, Martine, Habets, Kim L. L., Keulers, Tom G. H., van der Vlag, Johan, Cotter, Thomas G., van Berkel, Theo J. C., Biessen, Erik A. L.

“…Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As…”
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The production and secretion of complement component C1q by human mast cells by van Schaarenburg, Rosanne A., Suurmond, Jolien, Habets, Kim L.L., Brouwer, Mieke C., Wouters, Diana, Kurreeman, Fina A.S., Huizinga, Tom W.J., Toes, René E.M., Trouw, Leendert A.

“…•Fully differentiated mast cells express RNA of C1qA, C1qB and C1qC.•C1q secreted by mast cells is functionally active in haemolytic assays.•Mast cells in…”
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Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis by Lievens, Dirk, Habets, Kim L, Robertson, Anna-Karin, Laouar, Yasmina, Winkels, Holger, Rademakers, Timo, Beckers, Linda, Wijnands, Erwin, Boon, Louis, Mosaheb, Munir, Ait-Oufella, Hafid, Mallat, Ziad, Flavell, Richard A, Rudling, Mats, Binder, Christoph J, Gerdes, Norbert, Biessen, Erik A L, Weber, Christian, Daemen, Mat J A P, Kuiper, Johan, Lutgens, Esther

“…The importance of transforming growth factor beta (TGFβ) as an immune regulatory cytokine in atherosclerosis has been established. However, the role of TGFβ…”
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Targeted pH-dependent fluorescent activity-based cathepsin probes by Hoogendoorn, Sascha, Habets, Kim L, Passemard, Solène, Kuiper, Johan, van der Marel, Gijsbert A, Florea, Bogdan I, Overkleeft, Herman S

“…Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose…”
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Blocking Toll-Like Receptors 7 and 9 Reduces Postinterventional Remodeling via Reduced Macrophage Activation, Foam Cell Formation, and Migration by Karper, Jacco C, Ewing, Mark M, Habets, Kim L.L, de Vries, Margreet R, Peters, Erna A.B, van Oeveren-Rietdijk, Annemarie M, de Boer, Hetty C, Hamming, Jaap F, Kuiper, Johan, Kandimalla, Ekambar R, La Monica, Nicola, Jukema, J Wouter, Quax, Paul H.A

“…OBJECTIVE—The role of toll-like receptors (TLRs) in vascular remodeling is well established. However, the involvement of the endosomal TLRs is unknown. Here,…”
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Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice by Ye, Dan, Meurs, Illiana, Ohigashi, Megumi, Calpe-Berdiel, Laura, Habets, Kim L.L., Zhao, Ying, Kubo, Yoshiyuki, Yamaguchi, Akihito, Van Berkel, Theo J.C., Nishi, Tsuyoshi, Van Eck, Miranda

“…To determine the role of macrophage ATP-binding cassette transporter A5 (ABCA5) in cellular cholesterol homeostasis and atherosclerotic lesion development…”
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Correction: Effects of Deletion of Macrophage ABCA7 on Lipid Metabolism and the Development of Atherosclerosis in the Presence and Absence of ABCA1 by Meurs, Illiana, Calpe-Berdiel, Laura, Habets, Kim L. L., Zhao, Ying, Korporaal, Suzanne J. A., Mommaas, A. Mieke, Josselin, Emmanuelle, Hildebrand, Reeni B., Ye, Dan, Out, Ruud, Kuiper, Johan, Van Berkel, Theo J. C., Chimini, Giovanna, Van Eck, Miranda

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Abstract 153: NKT Cells Aggravate the Development of Abdominal Aortic Aneurysms by van Puijvelde, Gijs H, Foks, Amanda C, Bot, Ilze, Habets, Kim L, de Jager, Saskia C, ter Borg, Mariette N, van Berkel, Theo J, Quax, Paul, Kuiper, Johan

“…Abstract only Background: An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta mainly affecting men aged 60 years or older. Development of…”
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Abstract 542: Leukocyte TLR5 Deficiency Inhibits Atherosclerosis by Reduced Macrophage Recruitment and Defective T-Cell Responsiveness by de Jager, Saskia C, van Puijvelde, Gijs H, Anas, Adam A, Bot, Martine, Asbach, Miriam, Habets, Kim L, Foks, Amanda C, Pasterkamp, Gerard, van der Poll, Tom, Kuiper, Johan

“…Abstract only Background: Toll-like-receptors (TLRs) provide a critical link between innate and adaptive immune responses. It has been shown that TLR5 ligand…”
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