Search Results - "Haberbosch, Isabella"

Software tools for automated transmission electron microscopy by Schorb, Martin, Haberbosch, Isabella, Hagen, Wim J. H., Schwab, Yannick, Mastronarde, David N.

“…The demand for high-throughput data collection in electron microscopy is increasing for applications in structural and cellular biology. Here we present a…”
Get full text

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy by Nguyen, The Duy, Shaid, Shabnam, Vakhrusheva, Olesya, Koschade, Sebastian E., Klann, Kevin, Thölken, Marlyn, Baker, Fatima, Zhang, Jing, Oellerich, Thomas, Sürün, Duran, Derlet, Anja, Haberbosch, Isabella, Eimer, Stefan, Osiewacz, Heinz D., Behrends, Christian, Münch, Christian, Dikic, Ivan, Brandts, Christian H.

“…Autophagy maintains hematopoietic stem cell integrity and prevents malignant transformation. In addition to bulk degradation, selective autophagy serves as an…”
Get full text

BRAF inhibitor treatment in classic hairy cell leukemia: a long-term follow-up study of patients treated outside clinical trials by Liebers, Nora, Roider, Tobias, Bohn, Jan-Paul, Haberbosch, Isabella, Pircher, Andreas, Ferstl, Barbara, Ebnöther, Monika, Wendtner, Clemens-Martin, Dearden, Claire, Follows, George A., Ho, Anthony D., Müller-Tidow, Carsten, Dreger, Peter, Troussard, Xavier, Zenz, Thorsten, Dietrich, Sascha

Get full text

Protocol for high-throughput electron tomography exemplified on centrioles in primary human plasma cells by Köhrer, Sebastian, Dittrich, Tobias, Schorb, Martin, Haberbosch, Isabella, Schwab, Yannick, Krämer, Alwin

“…Electron microscopy is the gold standard to characterize cellular ultrastructure. However, production of significant morphometrical data is highly limited by…”
Get full text

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K by Mian, Afsar Ali, Haberbosch, Isabella, Khamaisie, Hazem, Agbarya, Abed, Pietsch, Larissa, Eshel, Elizabeh, Najib, Dally, Chiriches, Claudia, Ottmann, Oliver Gerhard, Hantschel, Oliver, Biondi, Ricardo M., Ruthardt, Martin, Mahajna, Jamal

“…Resistance remains the major clinical challenge for the therapy of Philadelphia chromosome–positive (Ph+) leukemia. With the exception of ponatinib, all…”
Get full text

High-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders by Köhrer, Sebastian, Dittrich, Tobias, Schorb, Martin, Weinhold, Niels, Haberbosch, Isabella, Börmel, Mandy, Pajor, Gabor, Goldschmidt, Hartmut, Müller-Tidow, Carsten, Raab, Marc S., John, Lukas, Seckinger, Anja, Brobeil, Alexander, Dreger, Peter, Tornóczky, Tamás, Pajor, László, Hegenbart, Ute, Schönland, Stefan O., Schwab, Yannick, Krämer, Alwin

“…Plasma cell disorders are clonal outgrowths of pre-malignant or malignant plasma cells, characterized by extensive chromosomal aberrations. Centrosome…”
Get full text

Multi-Modality Imaging Reveals Structural Centrosome Aberrations As a Potential Driver of Chromosomal Instability in Early-Stage Plasma Cell Disorders by Köhrer, Sebastian, Dittrich, Tobias, Schorb, Martin, Weinhold, Niels, Haberbosch, Isabella, Börmel, Mandy, Pajor, Gabor, Goldschmidt, Hartmut, Müller-Tidow, Carsten, Raab, Marc-Steffen, Brobeil, Alexander, Dreger, Peter, Hegenbart, Ute, Schönland, Stefan, Schwab, Yannick, Krämer, Alwin

“…Introduction Plasma cell disorders (PCD) are clonal outgrowths of pre-malignant or malignant plasma cells (PC), characterized by extensive chromosomal…”
Get full text

Transphosphorylation of Endogenous BCR Mediates the Effect of T315I on the Transformation Potential of BCR/ABL by Mian, Afsar, Haberbosch, Isabella, Ottmann, Oliver G., Ruthardt, Martin

“…Targeting of BCR/ABL by ABL-kinase inhibitors (AKI) such as Imatinib, Nilotinib, or Dasatinib is a proven concept in Philadelphia chromosome positive (Ph+ )…”
Get full text

High-Throughput Immunofluorescence and Electron Tomography to Characterize Centrosomal Aberrations in Plasma Cell Neoplasia by Dittrich, Tobias, Schorb, Martin, Haberbosch, Isabella, Bausch, Elena, Börmel, Mandy, Cosenza, Marco, Goldschmidt, Hartmut, Müller-Tidow, Carsten, Raab, Marc S, Hegenbart, Ute, Schönland, Stefan O., Schwab, Yannick, Krämer, Alwin

“…Introduction Genomic instability is the basic prerequisite for a Darwinian-type evolution of neoplasia and as such represents a fundamental hallmark of cancer…”
Get full text

A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial by Janssen, Maike, Schäkel, Ulrike, Djuka Fokou, Carine, Krisam, Johannes, Stermann, Jacek, Kriegsmann, Katharina, Haberbosch, Isabella, Novotny, Jan Philipp, Weber, Stefan, Vehreschild, Maria, Bornhäuser, Martin, Bullinger, Lars, Schmitt, Michael, Liebregts, Tobias, Dreger, Peter, Lorenz, Hanns-Martin, Plaszczyca, Anna, Bartenschlager, Ralf, Müller, Barbara, Kräusslich, Hans-Georg, Halama, Niels, Jäger, Dirk, Schlenk, Richard F, Leo, Albrecht, Meuer, Stefan, Weigand, Markus A, Motsch, Johann, Merle, Uta, Denkinger, Claudia M, Müller-Tidow, Carsten

“…Primary objectives • To assess the time from randomisation until an improvement within 84 days defined as two points on a seven point ordinal scale or live…”
Get full text

A high-throughput electron tomography workflow reveals over-elongated centrioles in relapsed/refractory multiple myeloma by Dittrich, Tobias, Köhrer, Sebastian, Schorb, Martin, Haberbosch, Isabella, Börmel, Mandy, Goldschmidt, Hartmut, Pajor, Gabor, Müller-Tidow, Carsten, Raab, Marc S., Hegenbart, Ute, Schönland, Stefan O., Schwab, Yannick, Krämer, Alwin

“…Electron microscopy is the gold standard to characterize centrosomal ultrastructure. However, production of significant morphometrical data is highly limited…”
Get full text

BCR: a new target in resistance mediated by BCR/ABL-315I? by Haberbosch, Isabella, Rafiei, Anahita, Oancea, Claudia, Ottmann, Gerhart Oliver, Ruthardt, Martin, Mian, Afsar Ali

“…Targeting BCR/ABL with Tyrosine kinase inhibitors (TKIs) is a proven concept for the treatment of Philadelphia chromosome-positive (Ph+) leukemias but the…”
Get full text

PF-114, a Novel Selective Pan BCR/ABL Inhibitor Targets The T315I and Suppress Models Of Advanced Ph+ ALL by Mian, Afsar, Rafiei, Anahita, Metodieva, Anna, Haberbosch, Isabella, Zeifman, Alexey, Titov, Ilya, Stroylov, Victor, Stroganov, Oleg, Novikov, Fedor, Ottmann, Oliver G., Chilov, Ghermes, Ruthardt, Martin

“…Targeting BCR/ABL by ABL-directed kinase inhibitors (AKIs) induces long lasting remissions in patients with chronic myeloid leukemia (CML), and short…”
Get full text

Synthetic patches, real images: screening for centrosome aberrations in EM images of human cancer cells by Lukoyanov, Artem, Haberbosch, Isabella, Pape, Constantin, Kraemer, Alwin, Schwab, Yannick, Kreshuk, Anna

“…Recent advances in high-throughput electron microscopy imaging enable detailed study of centrosome aberrations in cancer cells. While the image acquisition in…”
Get full text