Search Results - "Haber, James E"

DNA Repair: The Search for Homology by Haber, James E.

“…The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the…”
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The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair by Jasin, Maria, Haber, James E.

“…DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can lead to genomic change or cell death. Organisms have developed several…”
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Checkpoint Responses to DNA Double-Strand Breaks by Waterman, David P, Haber, James E, Smolka, Marcus B

“…Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell…”
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Homology Requirements and Competition between Gene Conversion and Break-Induced Replication during Double-Strand Break Repair by Mehta, Anuja, Beach, Annette, Haber, James E.

“…Saccharomyces cerevisiae mating-type switching is initiated by a double-strand break (DSB) at MATa, leaving one cut end perfectly homologous to the HMLα donor,…”
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Loop extrusion as a mechanism for formation of DNA damage repair foci by Arnould, Coline, Rocher, Vincent, Finoux, Anne-Laure, Clouaire, Thomas, Li, Kevin, Zhou, Felix, Caron, Pierre, Mangeot, Philippe. E., Ricci, Emiliano P., Mourad, Raphaël, Haber, James E., Noordermeer, Daan, Legube, Gaëlle

“…The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers…”
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Mutations Arising During Repair of Chromosome Breaks by Malkova, Anna, Haber, James E

“…Mutations stimulate evolutionary change and lead to birth defects and cancer in humans as well as to antibiotic resistance in bacteria. According to the…”
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Repair of a Site-Specific DNA Cleavage: Old-School Lessons for Cas9-Mediated Gene Editing by Gallagher, Danielle N, Haber, James E

“…CRISPR/Cas9-mediated gene editing may involve nonhomologous end-joining to create various insertion/deletions (indels) or may employ homologous recombination…”
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CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles by Lemos, Brenda R., Kaplan, Adam C., Bae, Ji Eun, Ferrazzoli, Alexander E., Kuo, James, Anand, Ranjith P., Waterman, David P., Haber, James E.

“…Harnessing CRISPR-Cas9 technology provides an unprecedented ability to modify genomic loci via DNA double-strand break (DSB) induction and repair. We analyzed…”
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Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks by Pham, Nhung, Yan, Zhenxin, Yu, Yang, Faria Afreen, Mosammat, Malkova, Anna, Haber, James E, Ira, Grzegorz

“…DNA synthesis during homologous recombination is highly mutagenic and prone to template switches. Two‐ended DNA double‐strand breaks (DSBs) are usually…”
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Deciphering the DNA Damage Response by Haber, James E.

“…This year’s Albert Lasker Basic Medical Research Award honors Evelyn Witkin and Stephen J. Elledge, two pioneers in elucidating the DNA damage response, whose…”
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PP2C phosphatases promote autophagy by dephosphorylation of the Atg1 complex by Memisoglu, Gonen, Eapen, Vinay V., Yang, Ying, Klionsky, Daniel J., Haber, James E.

“…Macroautophagy is orchestrated by the Atg1-Atg13 complex in budding yeast. Under nutrient-rich conditions, Atg13 is maintained in a hyperphosphorylated state…”
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Repair of mismatched templates during Rad51-dependent Break-Induced Replication by Choi, Jihyun, Kong, Muwen, Gallagher, Danielle N, Li, Kevin, Bronk, Gabriel, Cao, Yiting, Greene, Eric C, Haber, James E

“…Using budding yeast, we have studied Rad51-dependent break-induced replication (BIR), where the invading 3’ end of a site-specific double-strand break (DSB)…”
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Break-induced replication and telomerase-independent telomere maintenance require Pol32 by LYDEARD, John R, JAIN, Suvi, YAMAGUCHI, Miyuki, HABER, James E

“…Break-induced replication (BIR) is an efficient homologous recombination process to initiate DNA replication when only one end of a chromosome double-strand…”
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Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells by Costantino, Lorenzo, Sotiriou, Sotirios K., Rantala, Juha K., Magin, Simon, Mladenov, Emil, Helleday, Thomas, Haber, James E., Iliakis, George, Kallioniemi, Olli P., Halazonetis, Thanos D.

“…In budding yeast, one-ended DNA double-strand breaks (DSBs) and damaged replication forks are repaired by break-induced replication (BIR), a homologous…”
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Frequent Interchromosomal Template Switches during Gene Conversion in S. cerevisiae by Tsaponina, Olga, Haber, James E.

“…Although repair of double-strand breaks (DSBs) by gene conversion is the most accurate way to repair such lesions, in budding yeast there is a 1,000-fold…”
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Single-strand template repair: key insights to increase the efficiency of gene editing by Gallagher, Danielle N., Haber, James E.

“…DNA double-strand breaks (DSBs) pose a serious hazard for the stability of the genome. CRISPR-Cas9-mediated gene editing intentionally creates a site-specific…”
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Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks by Polleys, Erica J., Del Priore, Isabella, Haber, James E., Freudenreich, Catherine H.

“…Expanded CAG/CTG repeats are sites of DNA damage, leading to repeat length changes. Homologous recombination (HR) is one cause of repeat instability and we…”
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TOPping Off Meiosis by Haber, James E.

“…Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination…”
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Histone chaperones: an escort network regulating histone traffic by Almouzni, Geneviève, De Koning, Leanne, Corpet, Armelle, Haber, James E

“…In eukaryotes, DNA is organized into chromatin in a dynamic manner that enables it to be accessed for processes such as transcription and repair. Histones, the…”
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Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae by Garbacz, Marta A., Lujan, Scott A., Burkholder, Adam B., Cox, Phillip B., Wu, Qiuqin, Zhou, Zhi-Xiong, Haber, James E., Kunkel, Thomas A.

“…To investigate nuclear DNA replication enzymology in vivo, we have studied Saccharomyces cerevisiae strains containing a pol2-16 mutation that inactivates the…”
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