Search Results - "Haber, James"

Mating-type genes and MAT switching in Saccharomyces cerevisiae by Haber, James E

“…Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles, MATa and MATα. These sequences encode regulators of the two different…”
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DNA Repair: The Search for Homology by Haber, James E.

“…The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the…”
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A Life Investigating Pathways That Repair Broken Chromosomes by Haber, James E

“…Double-strand breaks (DSBs) pose a severe challenge to genome integrity; consequently, cells have developed efficient mechanisms to repair DSBs through several…”
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The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair by Jasin, Maria, Haber, James E.

“…DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can lead to genomic change or cell death. Organisms have developed several…”
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101 years ago: Hermann Muller's remarkable insight by Haber, James E

“…Abstract More than 20 years before DNA was identified as the hereditary material, the Drosophila geneticist, Hermann Muller, envisioned the fundamental…”
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Loop extrusion as a mechanism for formation of DNA damage repair foci by Arnould, Coline, Rocher, Vincent, Finoux, Anne-Laure, Clouaire, Thomas, Li, Kevin, Zhou, Felix, Caron, Pierre, Mangeot, Philippe. E., Ricci, Emiliano P., Mourad, Raphaël, Haber, James E., Noordermeer, Daan, Legube, Gaëlle

“…The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers…”
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A shattering experience by Haber, James E.

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Checkpoint Responses to DNA Double-Strand Breaks by Waterman, David P, Haber, James E, Smolka, Marcus B

“…Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell…”
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Sources of DNA double-strand breaks and models of recombinational DNA repair by Mehta, Anuja, Haber, James E

“…DNA is subject to many endogenous and exogenous insults that impair DNA replication and proper chromosome segregation. DNA double-strand breaks (DSBs) are one…”
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DNA replication: the recombination connection by Epum, Esther A., Haber, James E.

“…Failure to complete DNA replication is one of the major sources of genome instability leading to aneuploidy, chromosome breakage, and chromosome rearrangements…”
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Homology Requirements and Competition between Gene Conversion and Break-Induced Replication during Double-Strand Break Repair by Mehta, Anuja, Beach, Annette, Haber, James E.

“…Saccharomyces cerevisiae mating-type switching is initiated by a double-strand break (DSB) at MATa, leaving one cut end perfectly homologous to the HMLα donor,…”
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Deciphering the DNA Damage Response by Haber, James E.

“…This year’s Albert Lasker Basic Medical Research Award honors Evelyn Witkin and Stephen J. Elledge, two pioneers in elucidating the DNA damage response, whose…”
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A Rad51-independent pathway promotes single-strand template repair in gene editing by Gallagher, Danielle N, Pham, Nhung, Tsai, Annie M, Janto, Nicolas V, Choi, Jihyun, Ira, Grzegorz, Haber, James E

“…The Rad51/RecA family of recombinases perform a critical function in typical repair of double-strand breaks (DSBs): strand invasion of a resected DSB end into…”
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Mutations Arising During Repair of Chromosome Breaks by Malkova, Anna, Haber, James E

“…Mutations stimulate evolutionary change and lead to birth defects and cancer in humans as well as to antibiotic resistance in bacteria. According to the…”
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Repair of a Site-Specific DNA Cleavage: Old-School Lessons for Cas9-Mediated Gene Editing by Gallagher, Danielle N, Haber, James E

“…CRISPR/Cas9-mediated gene editing may involve nonhomologous end-joining to create various insertion/deletions (indels) or may employ homologous recombination…”
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Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break by Li, Kevin, Bronk, Gabriel, Kondev, Jane, Haber, James E.

“…One of the hallmarks of DNA damage is the rapid spreading of phosphorylated histone H2A (γ-H2AX) around a DNA double-strand break (DSB). In the budding yeast…”
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Cas9-mediated endogenous plasmid loss in Borrelia burgdorferi by Takacs, Constantin N, Nakajima, Yuko, Haber, James E, Jacobs-Wagner, Christine

“…The spirochete Borrelia burgdorferi, which causes Lyme disease, has the most segmented genome among known bacteria. In addition to a linear chromosome, the B…”
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CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles by Lemos, Brenda R., Kaplan, Adam C., Bae, Ji Eun, Ferrazzoli, Alexander E., Kuo, James, Anand, Ranjith P., Waterman, David P., Haber, James E.

“…Harnessing CRISPR-Cas9 technology provides an unprecedented ability to modify genomic loci via DNA double-strand break (DSB) induction and repair. We analyzed…”
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Migrating bubble during break-induced replication drives conservative DNA synthesis by Saini, Natalie, Ramakrishnan, Sreejith, Elango, Rajula, Ayyar, Sandeep, Zhang, Yu, Deem, Angela, Ira, Grzegorz, Haber, James E., Lobachev, Kirill S., Malkova, Anna

“…This paper demonstrates that the mechanism of break-induced replication (BIR) is significantly different from S-phase replication, as it proceeds via a…”
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Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks by Pham, Nhung, Yan, Zhenxin, Yu, Yang, Faria Afreen, Mosammat, Malkova, Anna, Haber, James E, Ira, Grzegorz

“…DNA synthesis during homologous recombination is highly mutagenic and prone to template switches. Two‐ended DNA double‐strand breaks (DSBs) are usually…”
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