Search Results - "Haber, JE"

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells by Costantino, Lorenzo, Sotiriou, Sotirios K., Rantala, Juha K., Magin, Simon, Mladenov, Emil, Helleday, Thomas, Haber, James E., Iliakis, George, Kallioniemi, Olli P., Halazonetis, Thanos D.

“…In budding yeast, one-ended DNA double-strand breaks (DSBs) and damaged replication forks are repaired by break-induced replication (BIR), a homologous…”
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Surviving the breakup: the DNA damage checkpoint by Harrison, Jacob C, Haber, James E

“…In response to even a single chromosomal double-strand DNA break, cells enact the DNA damage checkpoint. This checkpoint triggers cell cycle arrest, providing…”
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Partners and pathways: repairing a double-strand break by Haber, James E

“…Double-strand chromosome breaks can arise in a number of ways, by ionizing radiation, by spontaneous chromosome breaks during DNA replication, or by the…”
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Break-induced replication and recombinational telomere elongation in yeast by McEachern, Michael J, Haber, James E

“…When a telomere becomes unprotected or if only one end of a chromosomal double-strand break succeeds in recombining with a template sequence, DNA can be…”
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DNA Damage Response Pathway Uses Histone Modification to Assemble a Double-Strand Break-Specific Cohesin Domain by Ünal, Elçin, Arbel-Eden, Ayelet, Sattler, Ulrike, Shroff, Robert, Lichten, Michael, Haber, James E., Koshland, Douglas

“…The postreplicative repair of double-strand breaks (DSBs) is thought to require sister chromatid cohesion, provided by the cohesin complex along the chromosome…”
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INO80 and γ-H2AX Interaction Links ATP-Dependent Chromatin Remodeling to DNA Damage Repair by Morrison, Ashby J., Highland, Jessica, Krogan, Nevan J., Arbel-Eden, Ayelet, Greenblatt, Jack F., Haber, James E., Shen, Xuetong

“…While the role of ATP-dependent chromatin remodeling in transcription is well established, a link between chromatin remodeling and DNA repair has remained…”
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In Vivo Roles of Rad52, Rad54, and Rad55 Proteins in Rad51-Mediated Recombination by Sugawara, Neal, Wang, Xuan, Haber, James E.

“…Repairing a double-strand break by homologous recombination requires binding of the strand exchange protein Rad51p to ssDNA, followed by synapsis with a…”
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A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery by Lieberman, Judy, Keogh, Michael-Christopher, Downey, Michael, Chowdhury, Dipanjan, Datta, Nira, Harrison, Jacob C, Emili, Andrew, Haber, James E, Krogan, Nevan J, Durocher, Daniel, Fillingham, Jeffrey, Greenblatt, Jack F, Galicia, Sarah, Shen, Xuetong, Buratowski, Stephen, Kim, Jung-Ae, Onishi, Megumi

“…One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at the carboxy-terminal SQE motif…”
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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1 by Ira, G, Pellicioli, A, Balijja, A, Wang, X, Florani, S, Carotenuto, W, Liberi, G, Bressan, D, Wan, L, Hollingsworth, N.M

“…A single double-strand break (DSB) induced by HO endonuclease triggers both repair by homologous recombination and activation of the Mec1-dependent DNA damage…”
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Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break by Shroff, Robert, Arbel-Eden, Ayelet, Pilch, Duane, Ira, Grzegorz, Bonner, William M., Petrini, John H., Haber, James E., Lichten, Michael

“…Background: In response to DNA double-strand breaks (DSBs), eukaryotic cells rapidly phosphorylate histone H2A isoform H2AX at a C-terminal serine (to form…”
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Replicon Dynamics, Dormant Origin Firing, and Terminal Fork Integrity after Double-Strand Break Formation by Doksani, Ylli, Bermejo, Rodrigo, Fiorani, Simona, Haber, James E., Foiani, Marco

“…In response to replication stress, the Mec1/ATR and SUMO pathways control stalled- and damaged-fork stability. We investigated the S phase response at forks…”
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DNA recombination: the replication connection by Haber, James E

“…Chromosomal double-strand breaks (DSBs) arise after exposure to ionizing radiation or enzymatic cleavage, but especially during the process of DNA replication…”
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Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae by PAQUES, F, HABER, J. E

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The Many Interfaces of Mre11 by Haber, James E

“…One of the most memorable parody advertisements from the television program "Saturday Night Live" touted a product that was both a dessert topping and a floor…”
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Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase by Liberi, Giordano, Maffioletti, Giulio, Lucca, Chiara, Chiolo, Irene, Baryshnikova, Anastasia, Cotta-Ramusino, Cecilia, Lopes, Massimo, Pellicioli, Achille, Haber, James E, Foiani, Marco

“…S-phase cells overcome chromosome lesions through replication-coupled recombination processes that seem to be assisted by recombination-dependent DNA…”
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Transpositions and translocations induced by site-specific double-strand breaks in budding yeast by Haber, James E.

“…Much of what we know about the molecular mechanisms of repairing a broken chromosome has come from the analysis of site-specific double-strand breaks (DSBs)…”
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Yeast Mre11 and Rad1 Proteins Define a Ku-Independent Mechanism To Repair Double-Strand Breaks Lacking Overlapping End Sequences by Ma, Jia-Lin, Kim, Eun Mi, Haber, James E., Lee, Sang Eun

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Characterization of RAD51-Independent Break-Induced Replication That Acts Preferentially with Short Homologous Sequences by Ira, Grzegorz, Haber, James E.

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Heteroduplex Rejection during Single-Strand Annealing Requires Sgs1 Helicase and Mismatch Repair Proteins Msh2 and Msh6 but Not Pms1 by Sugawara, Neal, Goldfarb, Tamara, Studamire, Barbara, Alani, Eric, Haber, James E., Fox, Maurice S.

“…Recombination between moderately divergent DNA sequences is impaired compared with identical sequences. In yeast, an HO endonuclease-induced double-strand…”
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Anaphase Onset before Complete DNA Replication with Intact Checkpoint Responses by Torres-Rosell, Jordi, De Piccoli, Giacomo, Cordon-Preciado, Violeta, Farmer, Sarah, Jarmuz, Adam, Machin, Felix, Pasero, Philippe, Lisby, Michael, Haber, James E., Aragón, Luis

“…Cellular checkpoints prevent mitosis in the presence of stalled replication forks. Whether checkpoints also ensure the completion of DNA replication before…”
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