Search Results - "Habener, Joel F"

Discovery, characterization, and clinical development of the glucagon-like peptides by Drucker, Daniel J, Habener, Joel F, Holst, Jens Juul

“…The discovery, characterization, and clinical development of glucagon-like-peptide-1 (GLP-1) spans more than 30 years and includes contributions from multiple…”
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Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation by Liu, Zhengyu, Habener, Joel F.

“…The insulinotropic hormone GLP-1 (glucagon-like peptide-1) is a new therapeutic agent that preserves or restores pancreatic beta cell mass. We report that…”
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Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis by Tomas, Eva, Habener, Joel F

“…GLP-1 (9-36)amide is the cleavage product of GLP-1(7-36) amide, formed by the action of diaminopeptidyl peptidase-4 (Dpp4), and is the major circulating form…”
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Evolving function and potential of pancreatic alpha cells by Stanojevic, Violeta, M.A., M.Phil, Habener, Joel F., M.D

“…The alpha cells that co-occupy the islets in association with beta cells have been long recognized as the source of glucagon, a hyperglycemia-producing and…”
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GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice by Tomas, Eva, Stanojevic, Violeta, McManus, Karen, Khatri, Ashok, Everill, Paul, Bachovchin, William W, Habener, Joel F

“…The prevalence of obesity-related diabetes is increasing worldwide. Here we report the identification of a pentapeptide, GLP-1(32-36)amide (LVKGRamide),…”
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Minireview: Transcriptional Regulation in Pancreatic Development by Habener, Joel F, Kemp, Daniel M, Thomas, Melissa K

“…Considerable progress has been made in the understanding of the sequential activation of signal transduction pathways and the expression of transcription…”
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Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats by Li, Wan-Chun, Rukstalis, J. Michael, Nishimura, Wataru, Tchipashvili, Vaja, Habener, Joel F, Sharma, Arun, Bonner-Weir, Susan

“…The adult pancreas has considerable capacity to regenerate in response to injury. We hypothesized that after partial pancreatectomy (Px) in adult rats,…”
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Inhibition of Cyclin-dependent Kinase 5 Activity Protects Pancreatic Beta Cells from Glucotoxicity by Ubeda, Mariano, Rukstalis, J. Michael, Habener, Joel F.

“…Type 2 diabetes (T2D) and Alzheimer disease are degenerative diseases that may share common pathophysiologic mechanisms. Neuronal dysfunction in Alzheimer…”
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α-cell role in β-cell generation and regeneration by Habener, Joel F., Stanojevic, Violeta

“…This review considers the role of α-cells in β-cell generation and regeneration. We describe recent evidence obtained from lineage-tracing studies showing that…”
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Stromal Cell–Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic β-Cell Survival by Activation of the Prosurvival Kinase Akt by Yano, Tatsuya, Liu, Zhengyu, Donovan, Jennifer, Thomas, Melissa K, Habener, Joel F

“…Stromal Cell–Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic β-Cell Survival by Activation of the Prosurvival Kinase Akt…”
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Neurogenin3: A master regulator of pancreatic islet differentiation and regeneration by Rukstalis, J. Michael, Habener, Joel F.

“…The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3, Neurog3) is critical for the development of the endocrine cells of the islets. Either…”
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No Evidence for Significant Transdifferentiation of Bone Marrow Into Pancreatic β-Cells In Vivo by LECHNER, Andreas, YANG, Yong-Guang, BLACKEN, Robyn A, LAN WANG, NOLAN, Anna L, HABENER, Joel F

“…No Evidence for Significant Transdifferentiation of Bone Marrow Into Pancreatic β-Cells In Vivo Andreas Lechner 1 , Yong-Guang Yang 2 , Robyn A. Blacken 1 ,…”
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Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes by ZULEWSKI, Henryk, ABRAHAM, Elizabeth J, GERLACH, Melissa J, DANIEL, Philip B, MORITZ, Wolfgang, MÜLLER, Beat, VALLEJO, Mario, THOMAS, Melissa K, HABENER, Joel F

“…Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic…”
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Cure of Overt Diabetes in NOD Mice by Transient Treatment With Anti-Lymphocyte Serum and Exendin-4 by OGAWA, Norihiko, LIST, James F, HABENER, Joel F, MAKI, Takashi

“…Cure of Overt Diabetes in NOD Mice by Transient Treatment With Anti-Lymphocyte Serum and Exendin-4 Norihiko Ogawa 1 , James F. List 2 , Joel F. Habener 2 and…”
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GLP-1 (9-36) Amide, Cleavage Product of GLP-1 (7-36) Amide, Is a Glucoregulatory Peptide by Elahi, Dariush, Egan, Josephine M., Shannon, Richard P., Meneilly, Graydon S., Khatri, Ashok, Habener, Joel F., Andersen, Dana K.

“…Objective: Glucagon‐like peptide‐1 (GLP‐1) (7–36) amide is a glucoregulatory hormone with insulinotropic and insulinomimetic actions. We determined whether the…”
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Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus by Lechner, Andreas, Habener, Joel F

“…In view of the recent success in pancreatic islet transplantation, interest in treating diabetes by the delivery of insulin-producing beta-cells has been…”
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Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas by Rukstalis, J. Michael, Habener, Joel F.

“…The mammalian pancreas develops by the expansion and morphogenesis of the epithelial cells of the foregut endoderm via the sequential activation of…”
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Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter by Lechner, Andreas, Leech, Colin A, Abraham, Elizabeth J, Nolan, Anna L, Habener, Joel F

“…The disease diabetes mellitus arises as a consequence of a failure of the β-cells in the islets of Langerhans of the pancreas to produce insulin in the amounts…”
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Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence by Stoffers, Doris A, Zinkin, Noah T, Stanojevic, Violeta, Clarke, William L, Habener, Joel F

“…The homeodomain protein IPF1 (also known as IDX1, STF1 and PDX1; see Methods) is critical for development of the pancreas in mice and is a key factor for the…”
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Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect by Habener, Joel F, Stanojevic, Violeta

“…The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al…”
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