Search Results - "Habashi, Jennifer P"

Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome by Brooke, Benjamin S, Habashi, Jennifer P, Judge, Daniel P, Patel, Nishant, Loeys, Bart, Dietz, Harry C

“…Murine studies suggest that aortic-root dilation in Marfan's syndrome is due to excessive signaling by transforming growth factor β (TGF-β) and can be…”
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Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism by Habashi, Jennifer P., Doyle, Jefferson J., Holm, Tammy M., Aziz, Hamza, Schoenhoff, Florian, Bedja, Djahida, Chen, YiChun, Modiri, Alexandra N., Judge, Daniel P., Dietz, Harry C.

“…Angiotensin II (AngII) mediates progression of aortic aneurysm, but the relative contribution of its type 1 (AT1) and type 2 (AT2) receptors remains unknown…”
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Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome by Habashi, Jennifer P, Judge, Daniel P, Holm, Tammy M, Cohn, Ronald D, Loeys, Bart L, Cooper, Timothy K, Myers, Loretha, Klein, Erin C, Liu, Guosheng, Calvi, Carla, Podowski, Megan, Neptune, Enid R, Halushka, Marc K, Bedja, Djahida, Gabrielson, Kathleen, Rifkin, Daniel B, Carta, Luca, Ramirez, Francesco, Huso, David L, Dietz, Harry C

“…Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected…”
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A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome by Doyle, Jefferson J, Doyle, Alexander J, Wilson, Nicole K, Habashi, Jennifer P, Bedja, Djahida, Whitworth, Ryan E, Lindsay, Mark E, Schoenhoff, Florian, Myers, Loretha, Huso, Nick, Bachir, Suha, Squires, Oliver, Rusholme, Benjamin, Ehsan, Hamid, Huso, David, Thomas, Craig J, Caulfield, Mark J, Van Eyk, Jennifer E, Judge, Daniel P, Dietz, Harry C

“…Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence…”
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Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome by MacFarlane, Elena Gallo, Parker, Sarah J, Shin, Joseph Y, Kang, Benjamin E, Ziegler, Shira G, Creamer, Tyler J, Bagirzadeh, Rustam, Bedja, Djahida, Chen, Yichun, Calderon, Juan F, Weissler, Katherine, Frischmeyer-Guerrerio, Pamela A, Lindsay, Mark E, Habashi, Jennifer P, Dietz, Harry C

“…The aortic root is the predominant site for development of aneurysm caused by heterozygous loss-of-function mutations in positive effectors of the transforming…”
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Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice by Holm, Tammy M., Habashi, Jennifer P., Doyle, Jefferson J., Bedja, Djahida, Chen, YiChun, van Erp, Christel, Lindsay, Mark E., Kim, David, Schoenhoff, Florian, Cohn, Ronald D., Loeys, Bart L., Thomas, Craig J., Patnaik, Samarjit, Marugan, Juan J., Judge, Daniel P., Dietz, Harry C.

“…Transforming growth factor—β (TGFβ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit…”
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Angiotensin II-dependent TGF-[Beta] signaling contributes to Loeys-Dietz syndrome vascular pathogenesis by Gallo, Elena M, Loch, David C, Habashi, Jennifer P, Calderon, Juan F, Chen, Yichun, Bedja, Djahida, van Erp, Christel, Gerber, Elizabeth E, Parker, Sarah J, Sauls, Kimberly, Judge, Daniel P, Cooke, Sara K, Lindsay, Mark E, Rouf, Rosanne, Myers, Loretha, Rhys, Colette M Ap, Kent, Kathleen C, Norris, Russell A, Huso, David L, Dietz, Harry C

“…Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by a high risk for aneurysm and dissection throughout the arterial tree and…”
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Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis by Gallo, Elena M, Loch, David C, Habashi, Jennifer P, Calderon, Juan F, Chen, Yichun, Bedja, Djahida, van Erp, Christel, Gerber, Elizabeth E, Parker, Sarah J, Sauls, Kimberly, Judge, Daniel P, Cooke, Sara K, Lindsay, Mark E, Rouf, Rosanne, Myers, Loretha, ap Rhys, Colette M, Kent, Kathleen C, Norris, Russell A, Huso, David L, Dietz, Harry C

“…Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by a high risk for aneurysm and dissection throughout the arterial tree and…”
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Angiotensin II type 1 receptor blockade attenuates TGF-β-induced failure of muscle regeneration in multiple myopathic states by Dietz, Harry C, Cohn, Ronald D, van Erp, Christel, Habashi, Jennifer P, Soleimani, Arshia A, Klein, Erin C, Lisi, Matthew T, Gamradt, Matthew, ap Rhys, Colette M, Holm, Tammy M, Loeys, Bart L, Ramirez, Francesco, Judge, Daniel P, Ward, Christopher W

“…Skeletal muscle has the ability to achieve rapid repair in response to injury or disease. Many individuals with Marfan syndrome (MFS), caused by a deficiency…”
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A Pkd1-Fbn1 Genetic Interaction Implicates TGF-β Signaling in the Pathogenesis of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease by DONGYAN LIU, WANG, Connie J, FENG QIAN, HUSO, David, DIETZ, Harry C, GERMINO, Gregory G, WATNICK, Terry, JUDGE, Daniel P, HALUSHKA, Marc K, JIE NI, HABASHI, Jennifer P, MOSLEHI, Javid, BEDJA, Djahida, GABRIELSON, Kathleen L, HANGXUE XU

“…Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of renal failure that is due to mutations in two genes, PKD1 and PKD2. Vascular…”
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Noncanonical TGF[beta] Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice by Holm, Tammy M, Habashi, Jennifer P, Doyle, Jefferson J, Bedja, Djahida, Chen, YiChun, Christel van Erp, Lindsay, Mark E, Kim, David, Schoenhoff, Florian, Cohn, Ronald D, Loeys, Bart L, Thomas, Craig J, Patnaik, Samarjit, Marugan, Juan J, Judge, Daniel P

“…Activation of transforming growth factor-β (TGF-β) signaling promotes the development of aortic aneurysms in the connective tissue disorder Marfan syndrome…”
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Erratum: Corrigendum: Angiotensin II type 1 receptor blockade attenuates TGF-β–induced failure of muscle regeneration in multiple myopathic states by Cohn, Ronald D, van Erp, Christel, Habashi, Jennifer P, Soleimani, Arshia A, Klein, Erin C, Lisi, Matthew T, Gamradt, Matthew, ap Rhys, Colette M, Holm, Tammy M, Loeys, Bart L, Ramirez, Francesco, Judge, Daniel P, Ward, Christopher W, Dietz, Harry C

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Corrigendum: Angiotensin II type 1 receptor blockade attenuates TGF-β-induced failure of muscle regeneration in multiple myopathic states by Cohn, Ronald D, van Erp, Christel, Habashi, Jennifer P, Soleimani, Arshia A, Klein, Erin C, Lisi, Matthew T, Gamradt, Matthew, ap Rhys, Colette M, Holm, Tammy M, Loeys, Bart L, Ramirez, Francesco, Judge, Daniel P, Ward, Christopher W, Dietz, Harry C

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Corrigendum: Angiotensin II type 1 receptor blockade attenuates TGF-[beta]-induced failure of muscle regeneration in multiple myopathic states by Cohn, Ronald D, Christel van Erp, Habashi, Jennifer P, Soleimani, Arshia A, Klein, Erin C, Lisi, Matthew T, Gamradt, Matthew, ap Rhys, Colette M, Holm, Tammy M, Loeys, Bart L, Ramirez, Francesco, Judge, Daniel P, Ward, Christopher W, Dietz, Harry C

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Angiotensin II type 1 receptor blockade attenuates TGF-[beta]-induced failure of muscle regeneration in multiple myopathic states by Cohn, Ronald D, Christel van Erp, Habashi, Jennifer P, Soleimani, Arshia A, Klein, Erin C, Lisi, Matthew T, Gamradt, Matthew, ap Rhys, Colette M, Holm, Tammy M, Loeys, Bart L, Ramirez, Francesco, Judge, Daniel P, Ward, Christopher W, Dietz, Harry C

“…Skeletal muscle has the ability to achieve rapid repair in response to injury or disease. Many individuals with Marfan syndrome (MFS), caused by a deficiency…”
Get full text