Insecticide resistance profiles in malaria vector populations from Sud-Kivu in the Democratic Republic of the Congo

Insecticide resistance profiles in malaria vector populations from Sud-Kivu in the Democratic Republic of the Congo

Insecticide resistance has become a widespread problem causing a decline in the effectiveness of vector control tools in sub-Saharan Africa. In this situation, ongoing monitoring of vector susceptibility to insecticides is encouraged by the WHO to guide national malaria control programmes. Our study...

Full description

Saved in:
Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 115; no. 11; pp. 1339 - 1344
Main Authors: N'Do, Sévérin, Bandibabone, Janvier B, Soma, Dieudonné D, Musaka, Bertin Z, Prudhomme, Jorian, Habamungu, Claude C, Namountougou, Moussa, Sangaré, Ibrahim, Kientega, Mahamadi, Kaboré, Didier A P, Bayili, Koama, Yerbanga, R Serge, Diabate, Abdoulaye, Dabire, Roch K, Ouedraogo, Jean-Bosco, Belem, Adrien M G, Boëte, Christophe, Guardiola-Claramonte, Maite, Chimanuka, Bantuzeko
Format: Journal Article
Language:English
Published: England 01-11-2021
Subjects:
Animals
Anopheles - genetics
Democratic Republic of the Congo - epidemiology
Humans
Insecticide Resistance - genetics
Insecticides - pharmacology
Malaria - prevention & control
Mosquito Control
Mosquito Vectors - genetics
Pyrethrins - pharmacology
Democratic Republic of the Congo
Anopheles funestus
Democratic Republic of the Congo
insecticide resistance
Anopheles gambiae
Malaria
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Insecticide resistance has become a widespread problem causing a decline in the effectiveness of vector control tools in sub-Saharan Africa. In this situation, ongoing monitoring of vector susceptibility to insecticides is encouraged by the WHO to guide national malaria control programmes. Our study was conducted from April to November 2018 in Tchonka (Sud-Kivu, Democratic Republic of the Congo) and reported primary data on the resistance status of Anopheles funestus and Anopheles gambiae. Insecticide susceptibility bioassays were performed on wild populations of A. funestus and A. gambiae using WHO insecticide-impregnated papers at discriminating concentration. In addition, PCR was performed to identify mosquito species and to detect kdr and ace-1R mutations involved in insecticide resistance. Bioassay results show resistance to all tested insecticides except pirimiphos-methyl, propoxur, fenitrothion and malathion with a mortality rate ranging from 95.48 to 99.86%. The addition of piperonyl butoxide (PBO) increased the susceptibility of vectors to deltamethrin and alpha-cypermethrin by exhibiting a mortality ranging from 91.50 to 95.86%. The kdr mutation was detected at high frequencies (approximately 0.98) within A. gambiae while ace-1R was not detected. This study provides useful data on the insecticide resistance profiles of malaria vector populations to better manage vector control. Our results highlight that, despite the high level of resistance, organophosphorus compounds and pyrethroids + PBO remain effective against the vectors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/trab116