Effects of Dietary Polyamines on the Promotion of Mammary Tumor in Rats

The effects of dietary polyamines have been investigated on 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)- induced carcinogenesis of the breast in rats by feeding spermidine (Spd) at three different concentrations. The cumulative incidence of mammary tumor in the group treated with PhIP pl...

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Bibliographic Details
Published in:	Journal of Health Science Vol. 48; no. 4; pp. 376 - 380
Main Authors:	Wada, Masahiro, Funada-Wada, Ulala, Mano, Hiroshi, Higashiguchi, Mizuka, Haba, Ryouta, Watanabe, Shew, Udaka, Shigezo
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 01-01-2002 Pharmaceutical Society of Japan, Nihon Yakugakkai
Subjects:	2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine carcinogenesis polyamine spermidine
Online Access:	Get full text
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Summary:	The effects of dietary polyamines have been investigated on 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)- induced carcinogenesis of the breast in rats by feeding spermidine (Spd) at three different concentrations. The cumulative incidence of mammary tumor in the group treated with PhIP plus Spd was 92% (low spermidine diet) and 68% (high spermidine diet), compared to 50% in the PhIP group with a control diet. These results suggest that dietary polyamines may enhance the promotion of PhIP- induced mammary carcinogenesis. In addition, however, a low spermidine diet can promote the development of tumor in rats, but on the other hand a high spermidine diet may suppress the mammary carcinogenesis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1344-9702 1347-5207
DOI:	10.1248/jhs.48.376