Search Results - "Haass, Christian"

If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline? by Haass, Christian, Selkoe, Dennis

“…Strong genetic evidence supports an imbalance between production and clearance of amyloid β-protein (Aβ) in people with Alzheimer disease (AD). Microglia that…”
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Initiation and propagation of neurodegeneration by Haass, Christian

“…Although substantial progress has been made in understanding the molecular and pathological bases of neurodegeneration, there have been few successes in the…”
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Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease by Lewcock, Joseph W., Schlepckow, Kai, Di Paolo, Gilbert, Tahirovic, Sabina, Monroe, Kathryn M., Haass, Christian

“…Alzheimer’s disease (AD) is currently untreatable, and therapeutic strategies aimed to slow cognitive decline have not yet been successful. Many of these…”
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Stress granules in neurodegeneration – lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma by Bentmann, Eva, Haass, Christian, Dormann, Dorothee

“…Stress granules (SGs) are cytoplasmic foci that rapidly form when cells are exposed to stress. They transiently store mRNAs encoding house‐keeping proteins and…”
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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences by Exner, Nicole, Lutz, Anne Kathrin, Haass, Christian, Winklhofer, Konstanze F

“…Neurons are critically dependent on mitochondrial integrity based on specific morphological, biochemical, and physiological features. They are characterized by…”
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Microglia states and nomenclature: A field at its crossroads by Paolicelli, Rosa C., Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C., Butovsky, Oleg, Carson, Monica J., Castellano, Bernardo, Colonna, Marco, Cowley, Sally A., Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L., de Strooper, Bart, Denes, Adam, Eggen, Bart J.L., Eyo, Ukpong, Galea, Elena, Garel, Sonia, Ginhoux, Florent, Glass, Christopher K., Gokce, Ozgun, Gomez-Nicola, Diego, González, Berta, Gordon, Siamon, Graeber, Manuel B., Greenhalgh, Andrew D., Gressens, Pierre, Greter, Melanie, Gutmann, David H., Haass, Christian, Heneka, Michael T., Heppner, Frank L., Hong, Soyon, Hume, David A., Jung, Steffen, Kettenmann, Helmut, Kipnis, Jonathan, Koyama, Ryuta, Lemke, Greg, Lynch, Marina, Majewska, Ania, Malcangio, Marzia, Malm, Tarja, Mancuso, Renzo, Masuda, Takahiro, Matteoli, Michela, McColl, Barry W., Miron, Veronique E., Molofsky, Anna Victoria, Monje, Michelle, Mracsko, Eva, Nadjar, Agnes, Neher, Jonas J., Neniskyte, Urte, Neumann, Harald, Noda, Mami, Peng, Bo, Peri, Francesca, Perry, V. Hugh, Popovich, Phillip G., Pridans, Clare, Priller, Josef, Prinz, Marco, Ragozzino, Davide, Ransohoff, Richard M., Salter, Michael W., Schaefer, Anne, Schafer, Dorothy P., Schwartz, Michal, Simons, Mikael, Smith, Cody J., Streit, Wolfgang J., Tay, Tuan Leng, Tsai, Li-Huei, Verkhratsky, Alexei, von Bernhardi, Rommy, Wake, Hiroaki, Wittamer, Valérie, Wolf, Susanne A., Wu, Long-Jun, Wyss-Coray, Tony

“…Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as “resting versus activated”…”
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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases by Krasemann, Susanne, Madore, Charlotte, Cialic, Ron, Baufeld, Caroline, Calcagno, Narghes, El Fatimy, Rachid, Beckers, Lien, O’Loughlin, Elaine, Xu, Yang, Fanek, Zain, Greco, David J., Smith, Scott T., Tweet, George, Humulock, Zachary, Zrzavy, Tobias, Conde-Sanroman, Patricia, Gacias, Mar, Weng, Zhiping, Chen, Hao, Tjon, Emily, Mazaheri, Fargol, Hartmann, Kristin, Madi, Asaf, Ulrich, Jason D., Glatzel, Markus, Worthmann, Anna, Heeren, Joerg, Budnik, Bogdan, Lemere, Cynthia, Ikezu, Tsuneya, Heppner, Frank L., Litvak, Vladimir, Holtzman, David M., Lassmann, Hans, Weiner, Howard L., Ochando, Jordi, Haass, Christian, Butovsky, Oleg

“…Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a…”
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Regulated intramembrane proteolysis – lessons from amyloid precursor protein processing by Lichtenthaler, Stefan F., Haass, Christian, Steiner, Harald

“…J. Neurochem. (2011) 117, 779–796. Regulated intramembrane proteolysis (RIP) controls the communication between cells and the extracellular environment. RIP is…”
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Young microglia restore amyloid plaque clearance of aged microglia by Daria, Anna, Colombo, Alessio, Llovera, Gemma, Hampel, Heike, Willem, Michael, Liesz, Arthur, Haass, Christian, Tahirovic, Sabina

“…Alzheimer′s disease (AD) is characterized by deposition of amyloid plaques, neurofibrillary tangles, and neuroinflammation. In order to study microglial…”
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Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE by Parhizkar, Samira, Arzberger, Thomas, Brendel, Matthias, Kleinberger, Gernot, Deussing, Maximilian, Focke, Carola, Nuscher, Brigitte, Xiong, Monica, Ghasemigharagoz, Alireza, Katzmarski, Natalie, Krasemann, Susanne, Lichtenthaler, Stefan F., Müller, Stephan A., Colombo, Alessio, Monasor, Laura Sebastian, Tahirovic, Sabina, Herms, Jochen, Willem, Michael, Pettkus, Nadine, Butovsky, Oleg, Bartenstein, Peter, Edbauer, Dieter, Rominger, Axel, Ertürk, Ali, Grathwohl, Stefan A., Neher, Jonas J., Holtzman, David M., Meyer-Luehmann, Melanie, Haass, Christian

“…Coding variants in the triggering receptor expressed on myeloid cells 2 ( TREM2 ) are associated with late-onset Alzheimer’s disease (AD). We demonstrate that…”
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An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function by Schlepckow, Kai, Kleinberger, Gernot, Fukumori, Akio, Feederle, Regina, Lichtenthaler, Stefan F, Steiner, Harald, Haass, Christian

“…Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) support an essential function of microglia and…”
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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury by Mazaheri, Fargol, Snaidero, Nicolas, Kleinberger, Gernot, Madore, Charlotte, Daria, Anna, Werner, Georg, Krasemann, Susanne, Capell, Anja, Trümbach, Dietrich, Wurst, Wolfgang, Brunner, Bettina, Bultmann, Sebastian, Tahirovic, Sabina, Kerschensteiner, Martin, Misgeld, Thomas, Butovsky, Oleg, Haass, Christian

“…Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such…”
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The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases by Winklhofer, Konstanze F, Tatzelt, Jörg, Haass, Christian

“…The etiologies of neurodegenerative diseases may be diverse; however, a common pathological denominator is the formation of aberrant protein conformers and the…”
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Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects by Vassar, Robert, Kuhn, Peer‐Hendrik, Haass, Christian, Kennedy, Matthew E., Rajendran, Lawrence, Wong, Philip C., Lichtenthaler, Stefan F.

“…The β‐site APP cleaving enzymes 1 and 2 (BACE1 and BACE2) were initially identified as transmembrane aspartyl proteases cleaving the amyloid precursor protein…”
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Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury by Suárez-Calvet, Marc, Araque Caballero, Miguel Ángel, Kleinberger, Gernot, Bateman, Randall J, Fagan, Anne M, Morris, John C, Levin, Johannes, Danek, Adrian, Ewers, Michael, Haass, Christian

“…Emerging evidence supports a role for innate immunity and microglia in Alzheimer's disease (AD) pathophysiology. However, no marker related to microglia has…”
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ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import by Dormann, Dorothee, Rodde, Ramona, Edbauer, Dieter, Bentmann, Eva, Fischer, Ingeborg, Hruscha, Alexander, Than, Manuel E, Mackenzie, Ian R A, Capell, Anja, Schmid, Bettina, Neumann, Manuela, Haass, Christian

“…Mutations in fused in sarcoma ( FUS ) are a cause of familial amyotrophic lateral sclerosis (fALS). Patients carrying point mutations in the C‐terminus of FUS…”
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TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance by Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian

“…Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's disease (AD). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid…”
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DNA methylation changes in plasticity genes accompany the formation and maintenance of memory by Halder, Rashi, Hennion, Magali, Vidal, Ramon O, Shomroni, Orr, Rahman, Raza-Ur, Rajput, Ashish, Centeno, Tonatiuh Pena, van Bebber, Frauke, Capece, Vincenzo, Vizcaino, Julio C Garcia, Schuetz, Anna-Lena, Burkhardt, Susanne, Benito, Eva, Sala, Magdalena Navarro, Javan, Sanaz Bahari, Haass, Christian, Schmid, Bettina, Fischer, Andre, Bonn, Stefan

“…Learning and memory processes require experience-dependent changes in chromatin modifications. Here the authors provide a detailed view of the gene regulatory…”
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Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations by Mackenzie, Ian R., Arzberger, Thomas, Kremmer, Elisabeth, Troost, Dirk, Lorenzl, Stefan, Mori, Kohji, Weng, Shih-Ming, Haass, Christian, Kretzschmar, Hans A., Edbauer, Dieter, Neumann, Manuela

“…Hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of frontotemporal dementia and motor neuron disease. Recently, unconventional…”
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Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition by Colombo, Alessio Vittorio, Sadler, Rebecca Katie, Llovera, Gemma, Singh, Vikramjeet, Roth, Stefan, Heindl, Steffanie, Sebastian Monasor, Laura, Verhoeven, Aswin, Peters, Finn, Parhizkar, Samira, Kamp, Frits, Gomez de Aguero, Mercedes, MacPherson, Andrew J, Winkler, Edith, Herms, Jochen, Benakis, Corinne, Dichgans, Martin, Steiner, Harald, Giera, Martin, Haass, Christian, Tahirovic, Sabina, Liesz, Arthur

“…Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer's disease (AD) progression. However, the mechanisms of…”
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