Search Results - "Haase, Astrid D"

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  1. 1

    An introduction to PIWI-interacting RNAs (piRNAs) in the context of metazoan small RNA silencing pathways by Haase, Astrid D.

    Published in RNA biology (31-12-2022)
    “…PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a small RNA-based adaptive immune system that restricts the deleterious activity…”
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  2. 2

    The Structure of Human Argonaute-2 in Complex with miR-20a by Elkayam, Elad, Kuhn, Claus-D., Tocilj, Ante, Haase, Astrid D., Greene, Emily M., Hannon, Gregory J., Joshua-Tor, Leemor

    Published in Cell (06-07-2012)
    “…Argonaute proteins lie at the heart of the RNA-induced silencing complex (RISC), wherein they use small RNA guides to recognize targets. Initial insight into…”
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  3. 3

    A non-radioactive, improved PAR-CLIP and small RNA cDNA library preparation protocol by Anastasakis, Dimitrios G, Jacob, Alexis, Konstantinidou, Parthena, Meguro, Kazuyuki, Claypool, Duncan, Cekan, Pavol, Haase, Astrid D, Hafner, Markus

    Published in Nucleic acids research (07-05-2021)
    “…Abstract Crosslinking and immunoprecipitation (CLIP) methods are powerful techniques to interrogate direct protein-RNA interactions and dissect…”
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  4. 4

    Themes and variations on piRNA-guided transposon control by Loubalova, Zuzana, Konstantinidou, Parthena, Haase, Astrid D

    Published in Mobile DNA (02-09-2023)
    “…PIWI-interacting RNAs (piRNAs) are responsible for preventing the movement of transposable elements in germ cells and protect the integrity of germline…”
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  5. 5

    The Making of a Slicer: Activation of Human Argonaute-1 by Faehnle, Christopher R., Elkayam, Elad, Haase, Astrid D., Hannon, Gregory J., Joshua-Tor, Leemor

    Published in Cell reports (Cambridge) (01-06-2013)
    “…Argonautes are the central protein component in small RNA silencing pathways. Of the four human Argonautes (hAgo1–hAgo4) only hAgo2 is an active slicer. We…”
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  6. 6

    Decoding the 5′ nucleotide bias of PIWI-interacting RNAs by Stein, Chad B., Genzor, Pavol, Mitra, Sanga, Elchert, Alexandra R., Ipsaro, Jonathan J., Benner, Leif, Sobti, Sushil, Su, Yijun, Hammell, Molly, Joshua-Tor, Leemor, Haase, Astrid D.

    Published in Nature communications (19-02-2019)
    “…PIWI-interacting RNAs (piRNAs) are at the center of a small RNA-based immune system that defends genomes against the deleterious action of mobile genetic…”
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    Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas by Hickman, Alison B, Kailasan, Shweta, Genzor, Pavol, Haase, Astrid D, Dyda, Fred

    Published in eLife (08-01-2020)
    “…Key to CRISPR-Cas adaptive immunity is maintaining an ongoing record of invading nucleic acids, a process carried out by the Cas1-Cas2 complex that integrates…”
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  11. 11

    Hierarchical length and sequence preferences establish a single major piRNA 3′-end by Stoyko, Daniel, Genzor, Pavol, Haase, Astrid D.

    Published in iScience (17-06-2022)
    “…PIWI-interacting RNAs (piRNAs) guard germline genomes against the deleterious action of mobile genetic elements. PiRNAs use extensive base-pairing to recognize…”
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  12. 12

    A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements by Haase, Astrid D.

    Published in Stem cells international (01-01-2016)
    “…Transposons are mobile genetic elements that threaten the survival of species by destabilizing the germline genomes. Limiting the spread of these selfish…”
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  13. 13

    Aberrant expression of select piRNA-pathway genes does not reactivate piRNA silencing in cancer cells by Genzor, Pavol, Cordts, Seth C., Bokil, Neha V., Haase, Astrid D.

    “…Germline genes that are aberrantly expressed in nongermline cancer cells have the potential to be ideal targets for diagnosis and therapy due to their…”
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  14. 14

    The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs by Trabucchi, Michele, Briata, Paola, Garcia-Mayoral, MariaFlor, Haase, Astrid D., Filipowicz, Witold, Ramos, Andres, Gherzi, Roberto, Rosenfeld, Michael G.

    Published in Nature (London) (18-06-2009)
    “…Regulating the microRNA regulators As small RNAs exert profound effects on development and regulation of gene expression, their own expression must be…”
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  15. 15

    The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis by Ipsaro, Jonathan J., Haase, Astrid D., Knott, Simon R., Joshua-Tor, Leemor, Hannon, Gregory J.

    Published in Nature (London) (08-11-2012)
    “…piRNAs act to protect the genome from the damaging effect of unrestrained expression of mobile elements; here it is suggested that the phosphodiesterase…”
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  16. 16

    Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells by Sarshad, Aishe A., Juan, Aster H., Muler, Ana Iris Correa, Anastasakis, Dimitrios G., Wang, Xiantao, Genzor, Pavol, Feng, Xuesong, Tsai, Pei-Fang, Sun, Hong-Wei, Haase, Astrid D., Sartorelli, Vittorio, Hafner, Markus

    Published in Molecular cell (20-09-2018)
    “…In mammals, gene silencing by the RNA-induced silencing complex (RISC) is a well-understood cytoplasmic posttranscriptional gene regulatory mechanism. Here, we…”
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  17. 17

    PiRNAs Rise to Rescue Koalas by Haase, Astrid D., Macfarlan, Todd S.

    Published in Cell (17-10-2019)
    “…PIWI-interacting small RNAs (piRNAs) establish sequence-specific adaptive restriction of resident genomic parasites to guard genome integrity. In this issue of…”
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  18. 18

    PIWI-interacting RNAs: who, what, when, where, why, and how by Haase, Astrid D, Ketting, Rene F, Lai, Eric C, van Rij, Ronald P, Siomi, Mikiko, Svoboda, Petr, van Wolfswinkel, Josien C, Wu, Pei-Hsuan

    Published in The EMBO journal (26-09-2024)
    “…PIWI-interacting RNAs (piRNA) suppress selfish genetic elements and are essential for germ cell biology in animals. They also play critical roles in…”
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  19. 19

    Cellular abundance shapes function in piRNA-guided genome defense by Genzor, Pavol, Konstantinidou, Parthena, Stoyko, Daniel, Manzourolajdad, Amirhossein, Marlin Andrews, Celine, Elchert, Alexandra R, Stathopoulos, Constantinos, Haase, Astrid D

    Published in Genome research (01-11-2021)
    “…Defense against genome invaders universally relies on RNA-guided immunity. Prokaryotic CRISPR-Cas and eukaryotic RNA interference pathways recognize targets by…”
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  20. 20

    Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role by Anastasakis, Dimitrios G, Apostolidi, Maria, Garman, Khalid A, Polash, Ahsan H, Umar, Mubarak I, Meng, Qingcai, Scutenaire, Jérémy, Jarvis, Jordan E, Wang, Xiantao, Haase, Astrid D, Brownell, Isaac, Rinehart, Jesse, Hafner, Markus

    Published in Molecular cell (03-10-2024)
    “…Nuclear localization of the metabolic enzyme PKM2 is widely observed in various cancer types. We identify nuclear PKM2 as a non-canonical RNA-binding protein…”
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