Genetic analysis of the homeotic gene complex (HOM-C) in the beetle Tribolium castaneum

Our laboratories have undertaken both genetic and molecular studies of the homeotic gene complex (HOM-C) of the beetle Tribolium castaneum, and this paper discusses results from our genetic analyses. We describe here the adult phenotypes and complementation behavior of over 50 new mutations. Many of...

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Bibliographic Details
Published in:	Developmental biology Vol. 133; no. 1; pp. 196 - 209
Main Authors:	Beeman, Richard W., Stuart, Jeffrey J., Haas, M.Susan, Denell, Robin E.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01-05-1989 Elsevier
Subjects:	Abdomen - anatomy & histology Alleles ANIMAL DEVELOPMENTAL STAGES Animals Biological and medical sciences Chromosome Mapping Classical genetics, quantitative genetics, hybrids DROSOPHILA Drosophila melanogaster - anatomy & histology Drosophila melanogaster - genetics ETAPAS DEL DESARROLLO ANIMAL EVOLUCION EVOLUTION Fundamental and applied biological sciences. Psychology GENE GENES Genes, Homeobox GENETICA GENETICS Genetics of eukaryotes. Biological and molecular evolution GENETIQUE Head - anatomy & histology Invertebrata MUTACION MUTATION Phenotype STADE DE DEVELOPPEMENT ANIMAL Tenebrionidae Thorax - anatomy & histology Transformation, Genetic TRIBOLIUM Tribolium - anatomy & histology Tribolium - genetics Homeotic mutation Phenotype Coleoptera Arthropoda Insecta Morphology Inheritance Tribolium castaneum Invertebrata Tenebrionidae
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Summary:	Our laboratories have undertaken both genetic and molecular studies of the homeotic gene complex (HOM-C) of the beetle Tribolium castaneum, and this paper discusses results from our genetic analyses. We describe here the adult phenotypes and complementation behavior of over 50 new mutations. Many of these homeotic phenotypes resemble those of Drosophila melanogaster, but few precisely parallel the segmental transformations seen in this fly. Analysis of putative loss-of-function mutations affecting the head and thorax suggests that the maxillopedia and Cephalothorax genes most closely resemble proboscipedia and Sex combs reduced of Drosophila. In the abdomen, putative loss-of-function alleles of Abdominal affect a domain corresponding to those of the combined abdominal-A and Abdominal-B genes of Drosophila. In contrast to the situation in flies, Abdominal loss-of-function variants in Tribolium cause anteriorward transformations in A3–A5a, but posteriorward transformations in A5p–A7. The implications of the differences in developmental strategies evolved in Tribolium vs Drosophila are discussed.
Bibliography:	L10 8932019 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0012-1606 1095-564X
DOI:	10.1016/0012-1606(89)90311-4