Search Results - "Haas, Kevin R"

Expectation-Maximization of the Potential of Mean Force and Diffusion Coefficient in Langevin Dynamics from Single Molecule FRET Data Photon by Photon by Haas, Kevin R, Yang, Haw, Chu, Jhih-Wei

“…The dynamics of a protein along a well-defined coordinate can be formally projected onto the form of an overdamped Lagevin equation. Here, we present a…”
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Fisher information metric for the Langevin equation and least informative models of continuous stochastic dynamics by Haas, Kevin R, Yang, Haw, Chu, Jhih-Wei

“…The evaluation of the Fisher information matrix for the probability density of trajectories generated by the over-damped Langevin dynamics at equilibrium is…”
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Development and validation of a 36-gene sequencing assay for hereditary cancer risk assessment by Vysotskaia, Valentina S, Hogan, Gregory J, Gould, Genevieve M, Wang, Xin, Robertson, Alex D, Haas, Kevin R, Theilmann, Mark R, Spurka, Lindsay, Grauman, Peter V, Lai, Henry H, Jeon, Diana, Haliburton, Genevieve, Leggett, Matt, Chu, Clement S, Iori, Kevin, Maguire, Jared R, Ready, Kaylene, Evans, Eric A, Kang, Hyunseok P, Haque, Imran S

“…The past two decades have brought many important advances in our understanding of the hereditary susceptibility to cancer. Numerous studies have provided…”
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High-throughput fetal fraction amplification increases analytical performance of noninvasive prenatal screening by Welker, Noah C., Lee, Albert K., Kjolby, Rachel A. S., Wan, Helen Y., Theilmann, Mark R., Jeon, Diana, Goldberg, James D., Haas, Kevin R., Muzzey, Dale, Chu, Clement S.

“…Purpose The percentage of a maternal cell-free DNA (cfDNA) sample that is fetal-derived (the fetal fraction; FF) is a key driver of the sensitivity and…”
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Validation of an Expanded Carrier Screen that Optimizes Sensitivity via Full-Exon Sequencing and Panel-wide Copy Number Variant Identification by Hogan, Gregory J, Vysotskaia, Valentina S, Beauchamp, Kyle A, Seisenberger, Stefanie, Grauman, Peter V, Haas, Kevin R, Hong, Sun Hae, Jeon, Diana, Kash, Shera, Lai, Henry H, Melroy, Laura M, Theilmann, Mark R, Chu, Clement S, Iori, Kevin, Maguire, Jared R, Evans, Eric A, Haque, Imran S, Mar-Heyming, Rebecca, Kang, Hyunseok P, Muzzey, Dale

“…By identifying pathogenic variants across hundreds of genes, expanded carrier screening (ECS) enables prospective parents to assess the risk of transmitting an…”
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Analysis of Trajectory Entropy for Continuous Stochastic Processes at Equilibrium by Haas, Kevin R, Yang, Haw, Chu, Jhih-Wei

“…The analytical expression for the trajectory entropy of the overdamped Langevin equation is derived via two approaches. The first route goes through the…”
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Trajectory Entropy of Continuous Stochastic Processes at Equilibrium by Haas, Kevin R, Yang, Haw, Chu, Jhih-Wei

“…We propose to quantify the trajectory entropy of a dynamic system as the information content in excess of a free-diffusion reference model. The space–time…”
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Software-Assisted Manual Review of Clinical Next-Generation Sequencing Data: An Alternative to Routine Sanger Sequencing Confirmation with Equivalent Results in >15,000 Germline DNA Screens by Muzzey, Dale, Kash, Shera, Johnson, Jillian I, Melroy, Laura M, Kaleta, Piotr, Pierce, Kelly A, Ready, Kaylene, Kang, Hyunseok P, Haas, Kevin R

“…Clinical genomic tests increasingly use a next-generation sequencing (NGS) platform due in part to the high fidelity of variant calls, yet rare errors are…”
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Reaction Path Optimization with Holonomic Constraints and Kinetic Energy Potentials by Brokaw, Jason B, Haas, Kevin R, Chu, Jhih-Wei

“…Two methods are developed to enhance the stability, efficiency, and robustness of reaction path optimization using a chain of replicas. First, distances…”
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877: Rare adds up: Characterization of mosaicism in rare autosomal aneuploidies via noninvasive prenatal screening by Lee, Albert, Hancock, Susan, Haverty, Carrie, Haas, Kevin R.

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251: NIPS for high BMI patients: Evaluating the impact of deep whole genome sequencing on sensitivity and residual risk by Muzzey, Dale, Haverty, Carrie E., Artieri, Carlo G., D'Auria, Kevin M., Haas, Kevin R., Kang, H. Peter, Evans, Eric A.

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259: Copy number variant calling on a 176-disease expanded carrier screening panel by Muzzey, Dale, Beauchamp, Kyle A., Grauman, Peter, Hogan, Gregory J., Haas, Kevin R., Gould, Genevieve M., Wong, Kenny K., Lazarin, Gabriel, Evans, Eric A.

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Software-Assisted Manual Review of Clinical Next-Generation Sequencing Data by Muzzey, Dale, Kash, Shera, Johnson, Jillian I., Melroy, Laura M., Kaleta, Piotr, Pierce, Kelly A., Ready, Kaylene, Kang, Hyunseok P., Haas, Kevin R.

“…Clinical genomic tests increasingly use a next-generation sequencing (NGS) platform due in part to the high fidelity of variant calls, yet rare errors are…”
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