Search Results - "Haas, Joel T."

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease by Haas, Joel T, Francque, Sven, Staels, Bart

“…Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders characterized by abnormal hepatic fat accumulation, inflammation, and…”
Get full text

Dysregulated lipid metabolism links NAFLD to cardiovascular disease by Deprince, Audrey, Haas, Joel T., Staels, Bart

“…Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health problem. Cardiovascular diseases (CVD) are the most common cause of mortality in…”
Get full text

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets by Wilfling, Florian, Wang, Huajin, Haas, Joel T., Krahmer, Natalie, Gould, Travis J., Uchida, Aki, Cheng, Ji-Xin, Graham, Morven, Christiano, Romain, Fröhlich, Florian, Liu, Xinran, Buhman, Kimberly K., Coleman, Rosalind A., Bewersdorf, Joerg, Farese, Robert V., Walther, Tobias C.

“…Lipid droplets (LDs) store metabolic energy and membrane lipid precursors. With excess metabolic energy, cells synthesize triacylglycerol (TG) and form LDs…”
Get full text

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis by Chitraju, Chandramohan, Mejhert, Niklas, Haas, Joel T., Diaz-Ramirez, L. Grisell, Grueter, Carrie A., Imbriglio, Jason E., Pinto, Shirly, Koliwad, Suneil K., Walther, Tobias C., Farese, Robert V.

“…Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed…”
Get full text

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice by Pourcet, Benoit, Zecchin, Mathilde, Ferri, Lise, Beauchamp, Justine, Sitaula, Sadicha, Billon, Cyrielle, Delhaye, Stéphane, Vanhoutte, Jonathan, Mayeuf-Louchart, Alicia, Thorel, Quentin, Haas, Joel T., Eeckhoute, Jérome, Dombrowicz, David, Duhem, Christian, Boulinguiez, Alexis, Lancel, Steve, Sebti, Yasmine, Burris, Thomas P., Staels, Bart, Duez, Hélène M.

“…The innate immune system responds not only to bacterial signals, but also to non-infectious danger-associated molecular patterns that activate the NLRP3…”
Get full text

The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface by Xu, Ningyi, Zhang, Shaobing O, Cole, Ronald A, McKinney, Sean A, Guo, Fengli, Haas, Joel T, Bobba, Sudheer, Farese, Jr, Robert V, Mak, Ho Yi

“…At the subcellular level, fat storage is confined to the evolutionarily conserved compartments termed lipid droplets (LDs), which are closely associated with…”
Get full text

Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases by Eichmann, Thomas O., Kumari, Manju, Haas, Joel T., Farese, Robert V., Zimmermann, Robert, Lass, Achim, Zechner, Rudolf

“…Adipose triglyceride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, generating diacylglycerol (DAG) and fatty acids…”
Get full text

Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression by Haas, Joel T., Miao, Ji, Chanda, Dipanjan, Wang, Yanning, Zhao, Enpeng, Haas, Mary E., Hirschey, Matthew, Vaitheesvaran, B., Farese, Robert V., Kurland, Irwin J., Graham, Mark, Crooke, Rosanne, Foufelle, Fabienne, Biddinger, Sudha B.

“…Dissecting the role of insulin in the complex regulation of triglyceride metabolism is necessary for understanding dyslipidemia and steatosis. Liver insulin…”
Get full text

Roux-en-Y gastric bypass induces hepatic transcriptomic signatures and plasma metabolite changes indicative of improved cholesterol homeostasis by Lalloyer, Fanny, Mogilenko, Denis A., Verrijken, Ann, Haas, Joel T., Lamazière, Antonin, Kouach, Mostafa, Descat, Amandine, Caron, Sandrine, Vallez, Emmanuelle, Derudas, Bruno, Gheeraert, Céline, Baugé, Eric, Despres, Gaëtan, Dirinck, Eveline, Tailleux, Anne, Dombrowicz, David, Van Gaal, Luc, Eeckhoute, Jerôme, Lefebvre, Philippe, Goossens, Jean-François, Francque, Sven, Staels, Bart

“…Roux-en-Y gastric bypass (RYGB), the most effective surgical procedure for weight loss, decreases obesity and ameliorates comorbidities, such as non-alcoholic…”
Get full text

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes[S] by Harris, Charles A., Haas, Joel T., Streeper, Ryan S., Stone, Scot J., Kumari, Manju, Yang, Kui, Han, Xianlin, Brownell, Nicholas, Gross, Richard W., Zechner, Rudolf, Farese, Jr. Robert V.

“…The total contribution of the acyl CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been…”
Get full text

Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection by Heumel, Séverine, de Rezende Rodovalho, Vinícius, Urien, Charlotte, Specque, Florian, Brito Rodrigues, Patrícia, Robil, Cyril, Delval, Lou, Sencio, Valentin, Descat, Amandine, Deruyter, Lucie, Ferreira, Stéphanie, Gomes Machado, Marina, Barthelemy, Adeline, Angulo, Fabiola Silva, Haas, Joel T, Goosens, Jean François, Wolowczuk, Isabelle, Grangette, Corinne, Rouillé, Yves, Grimaud, Ghjuvan, Lenski, Marie, Hennart, Benjamin, Ramirez Vinolo, Marco Aurélio, Trottein, François

“…The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution…”
Get full text

Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution by Haas, Joel T., Vonghia, Luisa, Mogilenko, Denis A., Verrijken, An, Molendi-Coste, Olivier, Fleury, Sébastien, Deprince, Audrey, Nikitin, Artemii, Woitrain, Eloïse, Ducrocq-Geoffroy, Lucie, Pic, Samuel, Derudas, Bruno, Dehondt, Hélène, Gheeraert, Céline, Van Gaal, Luc, Driessen, Ann, Lefebvre, Philippe, Staels, Bart, Francque, Sven, Dombrowicz, David

“…Progression of fatty liver to non-alcoholic steatohepatitis (NASH) is a rapidly growing health problem. The presence of inflammatory infiltrates in the liver…”
Get full text

Hepatic insulin resistance directly promotes formation of cholesterol gallstones by Biddinger, Sudha B, Haas, Joel T, Yu, Bian B, Bezy, Olivier, Jing, Enxuan, Zhang, Wenwei, Unterman, Terry G, Carey, Martin C, Kahn, C Ronald

“…Despite the well-documented association between gallstones and the metabolic syndrome, the mechanistic links between these two disorders remain unknown. Here…”
Get full text

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis by Biddinger, Sudha B., Hernandez-Ono, Antonio, Rask-Madsen, Christian, Haas, Joel T., Alemán, José O., Suzuki, Ryo, Scapa, Erez F., Agarwal, Chhavi, Carey, Martin C., Stephanopoulos, Gregory, Cohen, David E., King, George L., Ginsberg, Henry N., Kahn, C. Ronald

“…Insulin resistance plays a central role in the development of the metabolic syndrome, but how it relates to cardiovascular disease remains controversial. Liver…”
Get full text

Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH by L’homme, Laurent, Sermikli, Benan Pelin, Haas, Joel T., Fleury, Sébastien, Quemener, Sandrine, Guinot, Valentine, Barreby, Emelie, Esser, Nathalie, Caiazzo, Robert, Verkindt, Hélène, Legendre, Benjamin, Raverdy, Violeta, Cheval, Lydie, Paquot, Nicolas, Piette, Jacques, Legrand-Poels, Sylvie, Aouadi, Myriam, Pattou, François, Staels, Bart, Dombrowicz, David

“…Plasma growth differentiation factor-15 (GDF-15) levels increase with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) but the…”
Get full text

Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells by Saka, Hector Alex, Thompson, J Will, Chen, Yi-Shan, Dubois, Laura G, Haas, Joel T, Moseley, Arthur, Valdivia, Raphael H

“…The obligate intracellular bacterium Chlamydia trachomatis is a major human pathogen and a main cause of genital and ocular diseases. During its intracellular…”
Get full text

Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome by Zanoni, Paolo, Panteloglou, Grigorios, Othman, Alaa, Haas, Joel T., Meier, Roger, Rimbert, Antoine, Futema, Marta, Abou Khalil, Yara, Norrelykke, Simon F., Rzepiela, Andrzej J., Stoma, Szymon, Stebler, Michael, van Dijk, Freerk, Wijers, Melinde, Wolters, Justina C., Dalila, Nawar, Huijkman, Nicolette C. A., Smit, Marieke, Gallo, Antonio, Carreau, Valérie, Philippi, Anne, Rabès, Jean-Pierre, Boileau, Catherine, Visentin, Michele, Vonghia, Luisa, Weyler, Jonas, Francque, Sven, Verrijken, An, Verhaegen, Ann, Van Gaal, Luc, van der Graaf, Adriaan, van Rosmalen, Belle V., Robert, Jerome, Velagapudi, Srividya, Yalcinkaya, Mustafa, Keel, Michaela, Radosavljevic, Silvija, Geier, Andreas, Tybjaerg-Hansen, Anne, Varret, Mathilde, Rohrer, Lucia, Humphries, Steve E., Staels, Bart, van de Sluis, Bart, Kuivenhoven, Jan Albert, von Eckardstein, Arnold

“…The LDLR (low-density lipoprotein receptor) in the liver is the major determinant of LDL-cholesterol levels in human plasma. The discovery of genes that…”
Get full text

Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia by Caron, Sandrine, Verrijken, An, Mertens, Ilse, Samanez, Carolina Huaman, Mautino, Gisèle, Haas, Joel T, Duran-Sandoval, Daniel, Prawitt, Janne, Francque, Sven, Vallez, Emmanuelle, Muhr-Tailleux, Anne, Berard, Isabelle, Kuipers, Folkert, Kuivenhoven, Jan A, Biddinger, Sudha B, Taskinen, Marja-Riitta, Van Gaal, Luc, Staels, Bart

“…OBJECTIVE—Hypertriglyceridemia and fatty liver are common in patients with type 2 diabetes, but the factors connecting alterations in glucose metabolism with…”
Get full text

NASH-related increases in plasma bile acid levels depend on insulin resistance by Grzych, Guillaume, Chávez-Talavera, Oscar, Descat, Amandine, Thuillier, Dorothée, Verrijken, An, Kouach, Mostafa, Legry, Vanessa, Verkindt, Hélène, Raverdy, Violeta, Legendre, Benjamin, Caiazzo, Robert, Van Gaal, Luc, Goossens, Jean-Francois, Paumelle, Réjane, Francque, Sven, Pattou, François, Haas, Joel T., Tailleux, Anne, Staels, Bart

“…Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from clinical…”
Get full text

Dissecting the role of insulin resistance in the metabolic syndrome by Haas, Joel T, Biddinger, Sudha B

“…Over 20 years ago, insulin resistance was postulated to play a central role in the pathogenesis of the metabolic syndrome. However, this has been difficult to…”
Get full text