Analysis of the Influence of Interleukin-1β Gene Polymorphism on Gastric Inflammatory Response and Precancerous Lesions Development in Patients with Functional Dyspepsia

Analysis of the Influence of Interleukin-1β Gene Polymorphism on Gastric Inflammatory Response and Precancerous Lesions Development in Patients with Functional Dyspepsia

The present study aimed to evaluate the influence of the IL1B -31C/T polymorphism on gastric inflammatory response and precancerous lesions development - atrophic gastritis (AG) and intestinal metaplasia (IM) - in patients positive for Helicobacter pylori infection with functional dyspepsia (FD). Th...

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Published in:Immunological investigations Vol. 49; no. 5; pp. 585 - 596
Main Authors: Rech, Tássia Flores, Mazzoleni, Luiz Edmundo, Mazzoleni, Felipe, Francesconi, Carlos Fernando de Magalhães, Sander, Guilherme Becker, Michita, Rafael Tomoya, Nabinger, Débora Dreher, de Bona, Laura Renata, Milbradt, Tobias Cancian, Ott, Eduardo André, Breyer, Helenice Pankowski, Haas, Gelline Maria, Canevese, Ane Paula, Stifft, Jonathas, Simon, Daniel
Format: Journal Article
Language:English
Published: England Taylor & Francis 03-07-2020
Subjects:
Adult
dyspepsia
Dyspepsia - genetics
Female
gastritis
Gastritis - genetics
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Helicobacter Infections - genetics
Helicobacter Infections - immunology
Helicobacter pylori
Helicobacter pylori - physiology
Humans
Inflammation - genetics
Interleukin-1beta
Interleukin-1beta - genetics
Male
metaplasia
Middle Aged
polymorphism
Polymorphism, Single Nucleotide
Precancerous Conditions
Interleukin-1beta
polymorphism
metaplasia
Helicobacter pylori
gastritis
dyspepsia
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Summary:The present study aimed to evaluate the influence of the IL1B -31C/T polymorphism on gastric inflammatory response and precancerous lesions development - atrophic gastritis (AG) and intestinal metaplasia (IM) - in patients positive for Helicobacter pylori infection with functional dyspepsia (FD). The diagnosis of FD followed the Rome III criteria, and the H. pylori infection was evaluated by urease test and histological examination of gastric biopsies (corpus, antrum, and incisura). The severity of chronic inflammation and inflammatory activity, as well as the presence of precancerous lesions were evaluated accordingly to the updated Sydney System. Genotyping of the IL1B -31C/T polymorphism (rs1143627) was performed by polymerase chain reaction-restriction fragment length polymorphism. A total of 303 patients positive for H. pylori infection with FD were analyzed (81.8% women; mean age of 46.3 ± 12.3 years). No differences were observed in overall genotype frequencies among outcomes evaluated. However, in the dominant -31C allele model (CC+CT vs. TT), the frequency of the TT genotype was significantly higher among patients with moderate/severe chronic inflammation of the antrum than the frequency of the CC+CT genotypes (80.8% vs. 65.2%; OR = 2.25; 95% CI = 1.23-4.24; P = .005). The presence of AG and IM in the gastric mucosa of patients was of 19.5% and 19.1%, respectively. No significant association was observed concerning the frequencies of the genotypes of IL1B -31C/T polymorphism with development of precancerous lesions. In conclusion, our data suggest that genetic variants of the IL1B -31C/T polymorphism play a role in chronic inflammation of the gastric mucosa in H. pylori-infected FD patients.
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ISSN:0882-0139
1532-4311
DOI:10.1080/08820139.2019.1710532