Search Results - "Haas, Arthur L"

The Active Form of E6-associated protein (E6AP)/UBE3A Ubiquitin Ligase Is an Oligomer by Ronchi, Virginia P., Klein, Jennifer M., Edwards, Daniel J., Haas, Arthur L.

“…Employing 125I-polyubiquitin chain formation as a functional readout of ligase activity, biochemical and biophysical evidence demonstrates that catalytically…”
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Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation by Chiok, Kim, Pokharel, Swechha M, Mohanty, Indira, Miller, Lindsay Grace, Gao, Shou-Jiang, Haas, Arthur L, Tran, Kim C, Teng, Michael N, Bose, Santanu

“…Paramyxoviruses such as respiratory syncytial virus (RSV) are the leading cause of pneumonia in infants, the elderly, and immunocompromised individuals…”
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E6AP/UBE3A Ubiquitin Ligase Harbors Two E2∼ubiquitin Binding Sites by Ronchi, Virginia P., Klein, Jennifer M., Haas, Arthur L.

“…By exploiting 125I-polyubiquitin chain formation as a functional readout of enzyme activity, we have quantitatively examined the mechanism of human E6AP/UBE3A…”
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In silico modeling of the cryptic E2∼ubiquitin–binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly by Ronchi, Virginia P., Kim, Elizabeth D., Summa, Christopher M., Klein, Jennifer M., Haas, Arthur L.

“…To understand the mechanism for assembly of Lys48-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two…”
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Ubiquitin and ubiquitin‐modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU by Anderson, David M., Schmalzer, Katherine M., Sato, Hiromi, Casey, Monika, Terhune, Scott S., Haas, Arthur L., Feix, Jimmy B., Frank, Dara W.

“…Summary Pseudomonas aeruginosa is an opportunistic Gram‐negative pathogen that possesses a type III secretion system (T3SS) critical for evading innate…”
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ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells by Desai, Shyamal D, Reed, Ryan E, Burks, Julian, Wood, Laurence M, Pullikuth, Ashok K, Haas, Arthur L, Liu, Leroy F, Breslin, Jerome W, Meiners, Sally, Sankar, Surendran

“…The interferon-stimulated gene 15 (ISG15) pathway is highly elevated in breast cancer; however, very little is known about how the ISG15 pathway contributes to…”
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ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis Virus by Giannakopoulos, Nadia V, Arutyunova, Elena, Lai, Caroline, Lenschow, Deborah J, Haas, Arthur L, Virgin, Herbert Whiting

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway by Wood, Laurence M, Sankar, Surendran, Reed, Ryan E, Haas, Arthur L, Liu, Leroy F, McKinnon, Peter, Desai, Shyamal D

“…Ataxia Telangiectasia (A-T) is an inherited immunodeficiency disorder wherein mutation of the ATM kinase is responsible for the A-T pathogenesis. Although the…”
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E1-E2 Interactions in Ubiquitin and Nedd8 Ligation Pathways by Tokgöz, Zeynep, Siepmann, Thomas J., Streich, Frederick, Kumar, Brajesh, Klein, Jennifer M., Haas, Arthur L.

“…Initial rates of E1-catalyzed E2 transthiolation have been used as a reporter function to probe the mechanism of 125I-ubiquitin transfer between activation and…”
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Crystal Structure of the Interferon-induced Ubiquitin-like Protein ISG15 by Narasimhan, Jana, Wang, Ming, Fu, Zhuji, Klein, Jennifer M., Haas, Arthur L., Kim, Jung-Ja P.

“…The biological effects of the ISG15 protein arise in part from its conjugation to cellular targets as a primary response to interferon-α/β induction and other…”
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Identification of the Major Ubiquitin-binding Domain of the Pseudomonas aeruginosa ExoU A2 Phospholipase by Anderson, David M., Feix, Jimmy B., Monroe, Andrew L., Peterson, Francis C., Volkman, Brian F., Haas, Arthur L., Frank, Dara W.

“…Numerous Gram-negative bacterial pathogens use type III secretion systems to deliver effector molecules into the cytoplasm of a host cell. Many of these…”
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Characterizing the Monomer–Dimer Equilibrium of UbcH8/Ube2L6: A Combined SAXS and NMR Study by Kahraman, Kerem, Robson, Scott A., Göcenler, Oktay, Yenici, Cansu M., Tozkoparan Ceylan, Cansu D., Klein, Jennifer M., Dötsch, Volker, Elgin, Emine Sonay, Haas, Arthur L., Ziarek, Joshua J., Dağ, Çağdaş

“…Interferon-stimulated gene-15 (ISG15) is an interferon-induced protein with two ubiquitin-like (Ubl) domains linked by a short peptide chain and is a…”
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Convergent Evolution in the Assembly of Polyubiquitin Degradation Signals by the Shigella flexneri IpaH9.8 Ligase by Edwards, Daniel J., Streich, Frederick C., Ronchi, Virginia P., Todaro, Dustin R., Haas, Arthur L.

“…The human pathogen Shigella flexneri subverts host function and defenses by deploying a cohort of effector proteins via a type III secretion system. The IpaH…”
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Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer by Bohnsack, Richard N., Haas, Arthur L.

“…Human Nedd8-activating enzyme AppBp1-Uba3 was purified to apparent homogeneity from erythrocytes. In the presence of [2,8-3H]ATP and 125I-Nedd8, heterodimer…”
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RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system by Cho, Kyoung-in, Yi, Haiqing, Desai, Ria, Hand, Arthur R, Haas, Arthur L, Ferreira, Paulo A

“…The association of cargoes to kinesins is thought to promote kinesin activation, yet the validation of such a model with native cargoes is lacking because none…”
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MdmX Is a RING Finger Ubiquitin Ligase Capable of Synergistically Enhancing Mdm2 Ubiquitination by Badciong, James C., Haas, Arthur L.

“…It has been well documented that Mdm2 and its homologue MdmX not only are critical negative regulators of the tumor suppressor p53 but that both Mdm2 and MdmX…”
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Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway by Kotamraju, Srigiridhar, Tampo, Yoshiko, Keszler, Agnes, Chitambar, Christopher R, Joseph, Joy, Haas, Arthur L, Kalyanaraman, B

“…We investigated here the mechanism of cytoprotection of nitric oxide ( • NO) in bovine aortic endothelial cells treated with H 2 O 2 . NONOates were used as •…”
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Deubiquitinating Function of Adenovirus Proteinase by Balakirev, Maxim Y, Jaquinod, Michel, Haas, Arthur L, Chroboczek, Jadwiga

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Protein Interactions within the N-end Rule Ubiquitin Ligation Pathway by Siepmann, Thomas J, Bohnsack, Richard N, Tokgöz, Zeynep, Baboshina, Olga V, Haas, Arthur L

“…Rate studies have been employed as a reporter function to probe protein-protein interactions within a biochemically defined reconstituted N-end rule ubiquitin…”
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Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly by Todaro, Dustin R., Augustus-Wallace, Allison C., Klein, Jennifer M., Haas, Arthur L.

“…The NEDD4-2 (neural precursor cell–expressed developmentally down-regulated 4-2) HECT ligase catalyzes polyubiquitin chain assembly by an ordered two-step…”
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