Search Results - "Haan, Judy B. de"

Are reactive oxygen species still the basis for diabetic complications? by Di Marco, Elyse, Jha, Jay C, Sharma, Arpeeta, Wilkinson-Berka, Jennifer L, Jandeleit-Dahm, Karin A, de Haan, Judy B

“…Despite the wealth of pre-clinical support for a role for reactive oxygen and nitrogen species (ROS/RNS) in the aetiology of diabetic complications, enthusiasm…”
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A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy by Deliyanti, Devy, Lee, Jae Young, Petratos, Steven, Meyer, Colin J, Ward, Keith W, Wilkinson-Berka, Jennifer L, de Haan, Judy B

“…An imbalance in oxidative stress and antioxidant defense mechanisms contributes to the development of ischaemic retinopathies such as diabetic retinopathy and…”
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Nrf2 activators as attractive therapeutics for diabetic nephropathy by de Haan, Judy B

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Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo by Ballinger, Mandy L., Osman, Narin, Hashimura, Kazuhiko, Haan, Judy B. de, Jandeleit‐Dahm, Karin, Allen, Terri, Tannock, Lisa R., Rutledge, John C., Little, Peter J.

“…The ‘response to retention’ hypothesis of atherogenesis proposes that proteoglycans bind and retain low‐density lipoproteins (LDL) in the vessel wall…”
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Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications by Sharma, Arpeeta, Tate, Mitchel, Mathew, Geetha, Vince, James E, Ritchie, Rebecca H, de Haan, Judy B

“…It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that sterile inflammation which occurs…”
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Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? by Kourakis, Stephanie, Timpani, Cara A., de Haan, Judy B., Gueven, Nuri, Fischer, Dirk, Rybalka, Emma

“…Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best…”
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NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis by Gray, Stephen P, Di Marco, Elyse, Okabe, Jun, Szyndralewiez, Cedric, Heitz, Freddy, Montezano, Augusto C, de Haan, Judy B, Koulis, Christine, El-Osta, Assam, Andrews, Karen L, Chin-Dusting, Jaye P F, Touyz, Rhian M, Wingler, Kirstin, Cooper, Mark E, Schmidt, Harald H. H W, Jandeleit-Dahm, Karin A

“…BACKGROUND—In diabetes mellitus, vascular complications such as atherosclerosis are a major cause of death. The key underlying pathomechanisms are unclear…”
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Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy by Deliyanti, Devy, Alrashdi, Saeed F, Tan, Sih Min, Meyer, Colin, Ward, Keith W, de Haan, Judy B, Wilkinson-Berka, Jennifer L

“…Oxidative stress is a causal factor in the development of diabetic retinopathy; however, clinically relevant strategies to treat the disease by augmenting…”
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Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease by Østergaard, Jakob A, Jha, Jay C, Sharma, Arpeeta, Dai, Aozhi, Choi, Judy S Y, de Haan, Judy B, Cooper, Mark E, Jandeleit-Dahm, Karin

“…Activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome has been reported in diabetic…”
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Recent novel approaches to limit oxidative stress and inflammation in diabetic complications by Pickering, Raelene J, Rosado, Carlos J, Sharma, Arpeeta, Buksh, Shareefa, Tate, Mitchel, Haan, Judy B

“…Diabetes is considered a major burden on the healthcare system of Western and non‐Western societies with the disease reaching epidemic proportions globally…”
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Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy by Kourakis, Stephanie, Timpani, Cara A., de Haan, Judy B., Gueven, Nuri, Fischer, Dirk, Rybalka, Emma

“…Imbalances in redox homeostasis can result in oxidative stress, which is implicated in various pathological conditions including the fatal neuromuscular…”
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Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis by Sharma, Arpeeta, Sellers, Stephanie, Stefanovic, Nada, Leung, Cleo, Tan, Sih Min, Huet, Olivier, Granville, David J, Cooper, Mark E, de Haan, Judy B, Bernatchez, Pascal

“…Patients with diabetes have an increased risk of developing atherosclerosis. Endothelial dysfunction, characterized by the lowered bioavailability of…”
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The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction by Sharma, Arpeeta, Rizky, Luddwi, Stefanovic, Nada, Tate, Mitchel, Ritchie, Rebecca H, Ward, Keith W, de Haan, Judy B

“…Vascular dysfunction is a pivotal event in the development of diabetes-associated vascular disease. Increased inflammation and oxidative stress are major…”
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The Mechanisms of Restenosis and Relevance to Next Generation Stent Design by Clare, Jessie, Ganly, Justin, Bursill, Christina A, Sumer, Huseyin, Kingshott, Peter, de Haan, Judy B

“…Stents are lifesaving mechanical devices that re-establish essential blood flow to the coronary circulation after significant vessel occlusion due to coronary…”
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Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery by May, Lauren T, Bartolo, Belinda A, Harrison, David G, Guzik, Tomasz, Drummond, Grant R, Figtree, Gemma A, Ritchie, Rebecca H, Rye, Kerry-Anne, de Haan, Judy B

“…Cardiovascular disease (CVD) remains the leading cause of death worldwide. An ongoing challenge remains the development of novel pharmacotherapies to treat…”
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Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice by Rasmiena, Aliki A, Barlow, Christopher K, Stefanovic, Nada, Huynh, Kevin, Tan, Ricardo, Sharma, Arpeeta, Tull, Dedreia, de Haan, Judy B, Meikle, Peter J

“…Abstract Background and aim We previously reported a negative association of circulating plasmalogens (phospholipids with proposed atheroprotective properties)…”
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Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse by CHEW, Phyllis, YUEN, Derek Y. C, STEFANOVIC, Nada, PETE, Josefa, COUGHLAN, Melinda T, JANDELEIT-DAHM, Karin A, THOMAS, Merlin C, ROSENFELDT, Franklin, COOPER, Mark E, DE HAAN, Judy B

“…To investigate the effect of the GPx1-mimetic ebselen on diabetes-associated atherosclerosis and renal injury in a model of increased oxidative stress. The…”
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Cardiovascular characterisation of a novel mouse model that combines hypertension and diabetes co-morbidities by Sharma, Arpeeta, Choi, Judy S. Y., Watson, Anna M. D., Li, Leila, Sonntag, Thomas, Lee, Man K. S., Murphy, Andrew J., De Blasio, Miles, Head, Geoffrey A., Ritchie, Rebecca H., de Haan, Judy B.

“…Epidemiologic data suggest that the prevalence of hypertension in patients with diabetes mellitus is ∼1.5–2.0 times greater than in matched non-diabetic…”
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Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice by LEWIS, Paul, STEFANOVIC, Nada, DE HAAN, Judy B, PETE, Josefa, CALKIN, Anna C, GIUNTI, Sara, THALLAS-BONKE, Vicki, JANDELEIT -DAHM, Karin A, ALLEN, Terri J, KOLA, Ismail, COOPER, Mark E

“…Recent clinical studies have suggested a major protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx1) in diabetes-associated…”
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SOD2 in skeletal muscle: New insights from an inducible deletion model by Zhuang, Aowen, Yang, Christine, Liu, Yingying, Tan, Yanie, Bond, Simon T., Walker, Shannen, Sikora, Tim, Laskowski, Adrienne, Sharma, Arpeeta, de Haan, Judy B., Meikle, Peter J., Shimizu, Takahiko, Coughlan, Melinda T., Calkin, Anna C., Drew, Brian G.

“…Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently associated with impairments in skeletal muscle function and…”
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