Search Results - "Haan, A."
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Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces
Published in PLoS pathogens (13-08-2018)“…Interactions of influenza A virus (IAV) with sialic acid (SIA) receptors determine viral fitness and host tropism. Binding to mucus decoy receptors and…”
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Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin
Published in PLoS pathogens (27-08-2020)“…Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics. Most pandemics occurred upon adaptation of avian IAVs to humans. This adaptation…”
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Comprehensive Desmosome Mutation Analysis in North Americans With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Published in Circulation. Cardiovascular genetics (01-10-2009)“…Comprehensive Desmosome Mutation Analysis in North Americans With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy A. Dénise den Haan, MD ; Boon Yew…”
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Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner
Published in PLoS pathogens (01-11-2014)“…Enveloped viruses need to fuse with a host cell membrane in order to deliver their genome into the host cell. While some viruses fuse with the plasma membrane,…”
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Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway
Published in PLoS pathogens (01-03-2011)“…Influenza A virus (IAV) enters host cells upon binding of its hemagglutinin glycoprotein to sialylated host cell receptors. Whereas dynamin-dependent,…”
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Three mutations switch H7N9 influenza to human-type receptor specificity
Published in PLoS pathogens (15-06-2017)“…The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of…”
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ACE-DNV: Automatic classification of gaze events in dynamic natural viewing
Published in Behavior research methods (2024)“…Eye movements offer valuable insights for clinical interventions, diagnostics, and understanding visual perception. The process usually involves recording a…”
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Rituximab impairs immunoglobulin (Ig)M and IgG (subclass) responses after influenza vaccination in rheumatoid arthritis patients
Published in Clinical and experimental immunology (01-10-2014)“…Summary Rituximab (RTX) treatment in rheumatoid arthritis (RA) patients severely hampers humoral response after influenza vaccination as determined by…”
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Grading bloodstream infection risk using citrulline as a biomarker of intestinal mucositis in patients receiving intensive therapy
Published in Bone marrow transplantation (Basingstoke) (01-09-2022)“…Earlier studies have suggested that severe intestinal mucositis (IM; citrulline < 10 µmol/L) is an independent risk factor for bloodstream infections (BSI)…”
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Influenza A Virus Hemagglutinin–Neuraminidase–Receptor Balance: Preserving Virus Motility
Published in Trends in microbiology (Regular ed.) (01-01-2020)“…Influenza A viruses (IAVs) occasionally cross the species barrier and adapt to novel host species. This requires readjustment of the functional balance of the…”
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Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle
Published in Journal of virology (31-01-2020)“…Coronavirus (CoV) nucleocapsid (N) proteins are key for incorporating genomic RNA into progeny viral particles. In infected cells, N proteins are present at…”
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Reduced PTLD-related mortality in patients experiencing EBV infection following allo-SCT after the introduction of a protocol incorporating pre-emptive rituximab
Published in Bone marrow transplantation (Basingstoke) (01-11-2013)“…The mortality associated with post-transplant lymphoproliferative disorder (PTLD) induced by EBV infection can be reduced by monitoring EBV by…”
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The muscle fiber type–fiber size paradox: hypertrophy or oxidative metabolism?
Published in European journal of applied physiology (01-11-2010)“…An inverse relationship exists between striated muscle fiber size and its oxidative capacity. This relationship implies that muscle fibers, which are triggered…”
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Kinetic analysis of paramyxovirus-sialoglycan receptor interactions reveals virion motility
Published in PLoS pathogens (01-03-2023)“…Many viruses initiate infection by binding to sialoglycan receptors at the cell surface. Binding to such receptors comes at a cost, however, as the sheer…”
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Development of a Virosomal RSV Vaccine Containing 3D-PHAD® Adjuvant: Formulation, Composition, and Long-Term Stability
Published in Pharmaceutical research (01-09-2018)“…Purpose Characterization of virosomes, in late stage preclinical development as vaccines for Respiratory Syncytial Virus (RSV), with a membrane-incorporated…”
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Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions
Published in Nature communications (13-07-2022)“…Establishment of zoonotic viruses, causing pandemics like the Spanish flu and Covid-19, requires adaptation to human receptors. Pandemic influenza A viruses…”
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A standardized validity assessment protocol for physiological signals from wearable technology: Methodological underpinnings and an application to the E4 biosensor
Published in Behavior research methods (01-04-2020)“…Wearable physiological measurement devices for ambulatory research with novel sensing technology are introduced with ever increasing frequency, requiring fast,…”
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Experimental densities, dynamic viscosities and surface tensions of the ionic liquids series 1-ethyl-3-methylimidazolium acetate and dicyanamide and their binary and ternary mixtures with water and ethanol at T=(298.15 to 343.15K)
Published in The Journal of chemical thermodynamics (01-08-2012)“…► We measure density, surface tension and dynamic viscosity of two pure ILs. ► We measure binary and ternary densities with water and ethanol. ► We measure…”
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Enterovirus D68 receptor requirements unveiled by haploid genetics
Published in Proceedings of the National Academy of Sciences - PNAS (02-02-2016)“…Enterovirus D68 (EV-D68) is an emerging pathogen that can cause severe respiratory disease and is associated with cases of paralysis, especially among…”
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First international quality control programme for laboratories measuring antimicrobial drugs to support dose individualization in critically ill patients
Published in Journal of antimicrobial chemotherapy (19-01-2021)“…Abstract Objectives International quality control (proficiency testing) programmes are instituted to safeguard the analytical performance of laboratories and…”
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