Search Results - "Haaksma, J"

Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation by Crider, Beverly J., Risinger, George M., Haaksma, Carol J., Howard, Eric W., Tomasek, James J.

“…Myofibroblasts are contractile, smooth muscle-like cells that are characterized by the de novo expression of smooth muscle α-actin (SMαA) and normally function…”
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Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds by Mirastschijski, Ursula, Haaksma, Carol J., Tomasek, James J., Ågren, Magnus S.

“…In this study, we examined the impact of matrix metalloproteinases (MMP) on epithelialization, granulation tissue development, wound contraction, and α-smooth…”
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Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity by Tomasek, James J., Vaughan, Melville B., Kropp, Bradley P., Gabbiani, Giulio, Martin, Michael D., Haaksma, Carol J., Hinz, Boris

“…ABSTRACT During wound healing and fibrocontractive diseases fibroblasts acquire a smooth muscle cell‐like phenotype by differentiating into contractile force…”
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Prospective Evaluation of Early Cardiac Damage Induced by Epirubicin-Containing Adjuvant Chemotherapy and Locoregional Radiotherapy in Breast Cancer Patients by MEINARDI, M. T, VAN VELDHUISEN, D. J, VAN DER GRAAF, W. T. A, GIETEMA, J. A, DOLSMA, W. V, BOOMSMA, F, VAN DEN BERG, M. P, VOLKERS, C, HAAKSMA, J, DE VRIES, E. G. E, SLEIJFER, D. Th

“…To evaluate prospectively the cardiotoxic effects of epirubicin-containing adjuvant chemotherapy in breast cancer patients. Patients (median age, 46 years;…”
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Myoepithelial Cell Contraction and Milk Ejection Are Impaired in Mammary Glands of Mice Lacking Smooth Muscle Alpha-Actin1 by Haaksma, Carol J, Schwartz, Robert J, Tomasek, James J

“…Mammary myoepithelial cells are specialized smooth musclelike epithelial cells that express the smooth muscle actin isoform: smooth muscle alpha-actin (ACTA2)…”
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Long-term cardiac follow-up in survivors of a malignant bone tumour by Brouwer, CAJ, Gietema, JA, van den Berg, MP, Bink-Boelkens, MTE, Elzenga, NJ, Haaksma, J, Kamps, WA, Vonk, JM, de Vries, EGE, Postma, A

“…Background: Longitudinal studies of cardiac function in long-term childhood cancer survivors are scarce and frequently concern a median follow-up shorter than…”
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Myoepithelial Cell Contraction and Milk Ejection Are Impaired in Mammary Glands of Mice Lacking Smooth Muscle Alpha-Actin by HAAKSMA, Carol J, SCHWARTZ, Robert J, TOMASEK, James J

“…Mammary myoepithelial cells are specialized smooth musclelike epithelial cells that express the smooth muscle actin isoform: smooth muscle alpha-actin (ACTA2)…”
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The Dissociative Brain: Feature or ruled by Fantasy? by Reinders, A.A.T. Simone, Willemsen, A.T., van Ekeren, M.C., Vos, H.P., Haaksma, J., den Boer, J.A., Nijenhuis, E.R.

“…Three psycho-biological parameters were tested: subjective ratings, cardiovascular responses, and regional cerebral blood flow (rCBF) as measured with PET…”
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Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition by Tomasek, James J., Haaksma, Carol J., Schwartz, Robert J., Howard, Eric W.

“…The contractile phenotype and function of myofibroblasts have been proposed to play a critical role in wound closure. It has been hypothesized that smooth…”
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Decreased expression of smooth muscle alpha-actin results in decreased contractile function of the mouse bladder by Zimmerman, R A, Tomasek, J J, McRae, J, Haaksma, C J, Schwartz, R J, Lin, H K, Cowan, R L, Jones, A N, Kropp, B P

“…Smooth muscle alpha-actin (SMalphaA) is an important actin isoform for functional contractility in the mouse bladder. Alterations in the expression of SMalphaA…”
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Cellular structure and biology of Dupuytren's disease by Tomasek, J J, Vaughan, M B, Haaksma, C J

“…Numerous studies support the idea that the myofibroblast is a key cell responsible for the tissue contraction in Dupuytren's disease. In vitro models have been…”
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Predictors of ventricular tachyarrhythmia in high-risk myocardial infarction patients treated with primary coronary intervention by Timmer, J. R., Breet, N., Svilaas, T., Haaksma, J., Van Gelder, I. C., Zijlstra, F.

“…Background. We investigated the association between clinical characteristics, angiographic data and ventricular arrhythmia in patients with ST-elevation…”
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Identification and Cloning of the Membrane-associated Serine Protease, Hepsin, from Mouse Preimplantation Embryos by Vu, Thien-Khai H., Liu, Rose W., Haaksma, Carol J., Tomasek, James J., Howard, Eric W.

“…Previous studies have suggested the existence of a membrane-associated serine protease expressed by mammalian preimplantation embryos. In this study, we have…”
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Deletion of smooth muscle α-actin alters blood-retina barrier permeability and retinal function by TOMASEK, James J, HAAKSMA, Carol J, SCHWARTZ, Robert J, VUONG, Duc T, ZHANG, Sarah X, ASH, John D, MA, Jian-Xing, AL-UBAIDI, Muayyad R

“…Vascular smooth muscle (SM) cells and pericytes are essential for normal vascular development. SM alpha-actin null mice were used to determine whether vascular…”
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Detailed structure–activity relationship of indolecarboxamides as H4 receptor ligands by Engelhardt, Harald, de Esch, Iwan J.P., Kuhn, Daniel, Smits, Rogier A., Zuiderveld, Obbe P., Dobler, Julia, Mayer, Moriz, Lips, Sebastian, Arnhof, Heribert, Scharn, Dirk, Haaksma, Eric E.J., Leurs, Rob

“…A series of 76 derivatives of the indolecarboxamide 1 were synthesized, which allows a detailed SAR investigation of this well known scaffold. The data enable…”
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Regulation of α-Smooth Muscle Actin Expression in Granulation Tissue Myofibroblasts Is Dependent on the Intronic CArG Element and the Transforming Growth Factor-β1 Control Element by Tomasek, James J., McRae, Joel, Owens, Gary K., Haaksma, Carol J.

“…Myofibroblasts are specialized contractile fibroblasts that are critical in wound closure and tissue contracture. Generation of contractile force is correlated…”
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Effects of dietary fermentable carbohydrates on behavior and heat production in group-housed sows by Rijnen, M. M. J. A, Verstegen, M. W. A, Heetkamp, M. J. W, Haaksma, J, Schrama, J. W

“…The effects of dietary nonstarch polysaccharides (NSP) on behavior and heat production in group-housed sows were studied. Twelve groups of six nonpregnant sows…”
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MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype by Howard, Eric W., Crider, Beverly J., Updike, Dawn L., Bullen, Elizabeth C., Parks, Eileen E., Haaksma, Carol J., Sherry, David M., Tomasek, James J.

“…During wound healing, fibroblasts transition from quiescence to a migratory state, then to a contractile myofibroblast state associated with wound closure. We…”
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GRID/CPCA:  A New Computational Tool To Design Selective Ligands by Kastenholz, Mika A, Pastor, Manuel, Cruciani, Gabriele, Haaksma, Eric E. J, Fox, Thomas

“…We present a computational procedure aimed at understanding enzyme selectivity and guiding the design of drugs with respect to selectivity. It starts from a…”
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Effects of spinal cord stimulation on myocardial ischaemia during daily life in patients with severe coronary artery disease. A prospective ambulatory electrocardiographic study by de Jongste, M. J., Haaksma, J., Hautvast, R. W., Hillege, H. L., Meyler, P. W., Staal, M. J., Sanderson, J. E., Lie, K. I.

“…BACKGROUND--Spinal cord stimulation (SCS) may be a useful additional therapy for pain in patients with therapeutically refractory angina pectoris. But doubts…”
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