Search Results - "Haag, Simone M."

Signalling strength determines proapoptotic functions of STING by Gulen, Muhammet F., Koch, Ute, Haag, Simone M., Schuler, Fabian, Apetoh, Lionel, Villunger, Andreas, Radtke, Freddy, Ablasser, Andrea

“…Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is…”
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Targeting STING with covalent small-molecule inhibitors by Haag, Simone M., Gulen, Muhammet F., Reymond, Luc, Gibelin, Antoine, Abrami, Laurence, Decout, Alexiane, Heymann, Michael, van der Goot, F. Gisou, Turcatti, Gerardo, Behrendt, Rayk, Ablasser, Andrea

“…Aberrant activation of innate immune pathways is associated with a variety of diseases. Progress in understanding the molecular mechanisms of innate immune…”
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Optimized Nonviral Gene Disruption in Primary Murine and Human Myeloid Cells by Freund, Emily C, Haag, Simone M, Haley, Benjamin, Murthy, Aditya

“…Genetically engineered myeloid cells such as monocytes, macrophages, and dendritic cells have broad applications in basic and translational research. Their…”
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Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation by Guttman, Ofer, Le Thomas, Adrien, Marsters, Scot, Lawrence, David A, Gutgesell, Lauren, Zuazo-Gaztelu, Iratxe, Harnoss, Jonathan M, Haag, Simone M, Murthy, Aditya, Strasser, Geraldine, Modrusan, Zora, Wu, Thomas, Mellman, Ira, Ashkenazi, Avi

“…Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8+ T cells. DCs process internalized protein antigens into…”
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Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification by Haag, Simone M., Xie, Shiqi, Eidenschenk, Celine, Fortin, Jean-Philippe, Callow, Marinella, Costa, Mike, Lun, Aaron, Cox, Chris, Wu, Sunny Z., Pradhan, Rachana N., Lock, Jaclyn, Kuhn, Julia A., Holokai, Loryn, Thai, Minh, Freund, Emily, Nissenbaum, Ariane, Keir, Mary, Bohlen, Christopher J., Martin, Scott, Geiger-Schuller, Kathryn, Hejase, Hussein A., Yaspan, Brian L., Melo Carlos, Sandra, Turley, Shannon J., Murthy, Aditya

“…Macrophages exhibit remarkable functional plasticity, a requirement for their central role in tissue homeostasis. During chronic inflammation, macrophages…”
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Murine Monocyte and Macrophage Culture by Haag, Simone M, Murthy, Aditya

“…Myeloid progenitors in the bone marrow generate monocytes, macrophages, granulocytes and most dendritic cells. Even though these innate immune cells are part…”
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Alpha-1-Antitrypsin Levels and Genetic Variation of the Alpha-1-Antitrypsin Gene in Peyronie’s Disease by Hauck, Ekkehard W., Hauptmann, Arne, Haag, Simone M., Bohnert, Anette, Weidner, Wolfgang, Bein, Gregor, Hackstein, Holger

“…Objectives: Alpha-1-antitrypsin (α1-antitrypsin) is a major protease inhibitor controlling tissue degradation. Reduced α1-antitrypsin levels could result in a…”
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Alterations in the Transforming Growth Factor (TGF)-β Pathway as a Potential Factor in the Pathogenesis of Peyronie's Disease by Haag, Simone M, Hauck, Ekkehard W, Szardening-Kirchner, Carolin, Diemer, Thorsten, Cha, Eun-Sook, Weidner, Wolfgang, Eickelberg, Oliver

“…Abstract Objectives The development of fibrotic diseases is associated with alterations in the transforming growth factor β (TGF-β) pathway. We have…”
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Investigation of the Antifibrotic Effect of IFN-γ on Fibroblasts in a Cell Culture Model of Peyronie's Disease by Haag, Simone M, Hauck, Ekkehard W, Eickelberg, Oliver, Szardening-Kirchner, Carolin, Diemer, Thorsten, Weidner, Wolfgang

“…Abstract Objective A broad spectrum of options is available for treatment of Peyronie's disease; however, the effects of minimally invasive therapy are…”
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Upregulation of mRNA expression of MCP-1 by TGF- beta 1 in fibroblast cells from Peyronie's disease by Szardening-Kirchner, Carolin, Konrad, Lutz, Hauck, Ekkehard W, Haag, Simone M, Eickelberg, Oliver, Weidner, Wolfgang

“…Introduction: Peyronie's disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent…”
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Upregulation of mRNA expression of MCP-1 by TGF-β1 in fibroblast cells from Peyronie’s disease by Szardening-Kirchner, Carolin, Konrad, Lutz, Hauck, Ekkehard W., Haag, Simone M., Eickelberg, Oliver, Weidner, Wolfgang

“…Introduction Peyronie’s disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent…”
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Upregulation of mRNA expression of MCP-1 by TGF-[beta]1 in fibroblast cells from Peyronie's disease by Szardening-kirchner, Carolin, Konrad, Lutz, Hauck, Ekkehard W, Haag, Simone M, Eickelberg, Oliver, Weidner, Wolfgang

“…Peyronie's disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent studies from…”
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Investigation of the Antifibrotic Effect of IFN-γ on Fibroblasts in a Cell Culture Model of Peyronie's Disease. Commentary by HAAG, Simone M, HAUCK, Ekkehard W, EICKELBERG, Oliver, SZARDENING-KIRCHNER, Carolin, DIEMER, Thorsten, WEIDNER, Wolfgang, USTA, Mustafa F

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Upregulation of mRNA expression of MCP-1 by TGF-beta1 in fibroblast cells from Peyronie's disease by Szardening-Kirchner, Carolin, Konrad, Lutz, Hauck, Ekkehard W, Haag, Simone M, Eickelberg, Oliver, Weidner, Wolfgang

“…Peyronie's disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent studies from…”
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Alpha-1-antitrypsin levels and genetic variation of the alpha-1-antitrypsin gene in Peyronie's disease. Commentary by HAUCK, Ekkehard W, HAUPTMANN, Arne, HAAG, Simone M, BOHNERT, Anette, WEIDNER, Wolfgang, BEING, Gregor, HACKSTEIN, Holger, RALPH, David J

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