Search Results - "Haack, Fiete"

Relating simulation studies by provenance—Developing a family of Wnt signaling models by Budde, Kai, Smith, Jacob, Wilsdorf, Pia, Haack, Fiete, Uhrmacher, Adelinde M

“…For many biological systems, a variety of simulation models exist. A new simulation model is rarely developed from scratch, but rather revises and extends an…”
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Spatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cells by Haack, Fiete, Lemcke, Heiko, Ewald, Roland, Rharass, Tareck, Uhrmacher, Adelinde M

“…Canonical WNT/β-catenin signaling is a central pathway in embryonic development, but it is also connected to a number of cancers and developmental disorders…”
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Long-term stimulation with alternating electric fields modulates the differentiation and mineralization of human pre-osteoblasts by Sahm, Franziska, Freiin Grote, Vivica, Zimmermann, Julius, Haack, Fiete, Uhrmacher, Adelinde M., van Rienen, Ursula, Bader, Rainer, Detsch, Rainer, Jonitz-Heincke, Anika

“…Biophysical stimulation by electric fields can promote bone formation in bone defects of critical size. Even though, long-term effects of alternating electric…”
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Implications of different membrane compartmentalization models in particle-based in silico studies by Henning, Philipp, Köster, Till, Haack, Fiete, Burrage, Kevin, Uhrmacher, Adelinde M

“…Studying membrane dynamics is important to understand the cellular response to environmental stimuli. A decisive spatial characteristic of the plasma membrane…”
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Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling by Haack, Fiete, Köster, Till, Uhrmacher, Adelinde M.

“…Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of…”
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Multi-Transcript Level Profiling Revealed Distinct mRNA, miRNA, and tRNA-Derived Fragment Bio-Signatures for Coping Behavior Linked Haplotypes in HPA Axis and Limbic System by Gley, Kevin, Hadlich, Frieder, Trakooljul, Nares, Haack, Fiete, Murani, Eduard, Gimsa, Ulrike, Wimmers, Klaus, Ponsuksili, Siriluck

“…The molecular basis of porcine coping behavior (CB) relies on a sophisticated interplay of genetic and epigenetic features. Deep sequencing technologies…”
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Wnt signaling related transcripts and their relationship to energy metabolism in C2C12 myoblasts under temperature stress by Risha, Marua Abu, Ali, Asghar, Siengdee, Puntita, Trakooljul, Nares, Haack, Fiete, Dannenberger, Dirk, Wimmers, Klaus, Ponsuksili, Siriluck

“…Temperature stress is one of the main environmental stressors affecting the welfare, health and productivity of livestock. Temperature changes can modify cell…”
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Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits by Ponsuksili, Siriluck, Trakooljul, Nares, Hadlich, Frieder, Haack, Fiete, Murani, Eduard, Wimmers, Klaus

“…Regulation of microRNA (miRNA) expression contributes to a wide range of target gene expression and phenotypes. The miRNA expression in the liver, the central…”
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ROS Dependent Wnt/β-Catenin Pathway and Its Regulation on Defined Micro-Pillars-A Combined In Vitro and In Silico Study by Staehlke, Susanne, Haack, Fiete, Waldner, Anna-Christin, Koczan, Dirk, Moerke, Caroline, Mueller, Petra, Uhrmacher, Adelinde M, Nebe, J Barbara

“…The physico-chemical surface design of implants influences the surrounding cells. Osteoblasts on sharp-edged micro-topographies revealed an impaired cell…”
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Adaptive spectral clustering with application to tripeptide conformation analysis by Haack, Fiete, Fackeldey, Konstantin, Röblitz, Susanna, Scharkoi, Olga, Weber, Marcus, Schmidt, Burkhard

“…A decomposition of a molecular conformational space into sets or functions (states) allows for a reduced description of the dynamical behavior in terms of…”
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A flexible architecture for modeling and simulation of diffusional association by Haack, Fiete, Leye, Stefan, Uhrmacher, Adelinde M.

“…Up to now, it is not possible to obtain analytical solutions for complex molecular association processes (e.g. Molecule recognition in Signaling or catalysis)…”
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Exploring the mechanistic and temporal regulation of LRP6 endocytosis in canonical WNT signaling by Haack, Fiete, Budde, Kai, Uhrmacher, Adelinde M

“…Endocytosis plays a pivotal regulatory role in canonical WNT signaling. Internalization of the low-density lipoprotein receptor-related protein 6 (LRP6)…”
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Haplotypes of coping behavior associated QTL regions reveal distinct transcript profiles in amygdala and hippocampus by Gley, Kevin, Murani, Eduard, Haack, Fiete, Trakooljul, Nares, Zebunke, Manuela, Puppe, Birger, Wimmers, Klaus, Ponsuksili, Siriluck

“…•Coping behavior is linked to molecular changes in amygdala and hippocampus.•Expression changes of the limbic forebrain system match QTL for coping…”
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Deep sequencing of small non-coding RNA highlights brain-specific expression patterns and RNA cleavage by Haack, Fiete, Trakooljul, Nares, Gley, Kevin, Murani, Eduard, Hadlich, Frieder, Wimmers, Klaus, Ponsuksili, Siriluck

“…With the advance of high-throughput sequencing technology numerous new regulatory small RNAs have been identified, that broaden the variety of processing…”
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Reusing simulation experiment specifications to support developing models by successive extension by Peng, Danhua, Warnke, Tom, Haack, Fiete, Uhrmacher, Adelinde M.

“…Model development is a successive process of validating, revising, and extending models, and requires iterative execution of simulation experiments. While…”
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Exploring mechanistic and temporal regulation of LRP6 endocytosis in canonical WNT signaling by Haack, Fiete, Budde, Kai, Uhrmacher, Adelinde M

“…Endocytosis plays a pivotal regulatory role in canonical WNT signaling. Internalization of the LRP6 receptor complex can either promote or attenuate canonical…”
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Conceptual Models in Simulation Studies: Making it Explicit by Wilsdorf, Pia, Haack, Fiete, Uhrmacher, Adelinde M.

“…Conceptual models play an important role in conducting simulation studies. A formal or at least explicit specification of conceptual models is key for…”
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Genetically regulated hepatic transcripts and pathways orchestrate haematological, biochemical and body composition traits by Ponsuksili, Siriluck, Trakooljul, Nares, Hadlich, Frieder, Haack, Fiete, Murani, Eduard, Wimmers, Klaus

“…The liver is the central metabolic organ and exhibits fundamental functions in haematological traits. Hepatic expression, haematological, plasma biochemical,…”
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Exploiting Provenance and Ontologies In Supporting Best Practices For Simulation Experiments: A Case Study On Sensitivity Analysis by Wilsdorf, Pia, Fischer, Nadine, Haack, Fiete, Uhrmacher, Adelinde M.

“…Simulation studies are intricate processes and user support for conducting more consistent, systematic, and efficient simulation studies is needed. Simulation…”
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Reusing simulation experiment specifications in developing models by successive composition — a case study of the Wnt/β-catenin signaling pathway by Peng, Danhua, Warnke, Tom, Haack, Fiete, Uhrmacher, Adelinde M

“…With the increasing size and complexity of models, developing models by composing existing ones becomes more important. We exploit the idea of reusing…”
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