Search Results - "Hänze, Jörg"

Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature by Mittal, Manish, Roth, Markus, König, Peter, Hofmann, Simone, Dony, Eva, Goyal, Parag, Selbitz, Anne-Christin, Schermuly, Ralph Theo, Ghofrani, Hossein Ardeschir, Kwapiszewska, Grazyna, Kummer, Wolfgang, Klepetko, Walter, Hoda, Mir Ali Reza, Fink, Ludger, Hänze, Jörg, Seeger, Werner, Grimminger, Friedrich, Schmidt, Harald H.H.W, Weissmann, Norbert

“…Nonphagocytic NADPH oxidases have recently been suggested to play a major role in the regulation of physiological and pathophysiological processes, in…”
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Co-Regulation of Immune Checkpoint PD-L1 with Interferon-Gamma Signaling is Associated with a Survival Benefit in Renal Cell Cancer by Hänze, Jörg, Wegner, Moritz, Noessner, Elfriede, Hofmann, Rainer, Hegele, Axel

“…Background Programmed death ligand (PD-L1)-based immune checkpoint blockade therapy for metastatic renal cell carcinoma (RCC) achieves significant response…”
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Prostate specific membrane antigen (PSMA) in urothelial cell carcinoma (UCC) is associated with tumor grading and staging by Schreiber, Henner, Hänze, Jörg, Nimphius, Wilhelm, Verburg, Frederik Anton, Luster, Markus, Hofmann, Rainer, Hegele, Axel

“…Introduction Prostate specific membrane antigen (PSMA) has become a target for radionuclide imaging and therapy. Previous studies have shown that the…”
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Transcriptomic response of prostate cancer cells to carbon ion and photon irradiation with focus on androgen receptor and TP53 signaling by Hänze, Jörg, Mengen, Lilly M, Mernberger, Marco, Tiwari, Dinesh Kumar, Plagge, Thomas, Nist, Andrea, Subtil, Florentine S B, Theiss, Ulrike, Eberle, Fabian, Roth, Katrin, Lauth, Matthias, Hofmann, Rainer, Engenhart-Cabillic, Rita, Stiewe, Thorsten, Hegele, Axel

“…Radiotherapy is essential in the treatment of prostate cancer. An alternative to conventional photon radiotherapy is the application of carbon ions, which…”
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Comparison of the Effects of Carbon Ion and Photon Irradiation on the Angiogenic Response in Human Lung Adenocarcinoma Cells by Kamlah, Florentine, D.V.M, Hänze, Jörg, Ph.D, Arenz, Andrea, Ph.D, Seay, Ulrike, M.Sc, Hasan, Diya, PH.D, Juricko, Janko, M.D, Bischoff, Birgit, D.V.M, Gottschald, Oana R., Ph.D, Fournier, Claudia, Ph.D, Taucher-Scholz, Gisela, Ph.D, Scholz, Michael, Ph.D, Seeger, Werner, M.D, Engenhart-Cabillic, Rita, M.D, Rose, Frank, M.D

“…Purpose Radiotherapy resistance is a commonly encountered problem in cancer treatment. In this regard, stabilization of endothelial cells and release of…”
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Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling by Hänze, Jörg, Weissmann, Norbert, Grimminger, Friedrich, Seeger, Werner, Rose, Frank

“…Hypoxia-inducible factor (HIF) is an oxygen-dependent transcription factor that activates a diverse set of target genes, the products of which are involved in…”
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Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species by Goyal, Parag, Weissmann, Norbert, Grimminger, Friedrich, Hegel, Cornelia, Bader, Lucius, Rose, Frank, Fink, Ludger, Ghofrani, Hossein A, Schermuly, Ralph T, Schmidt, Harald H.H.W, Seeger, Werner, Hänze, Jörg

“…Hypoxia sensing and related signaling events, including activation of hypoxia-inducible factor 1 (HIF-1), represent key features in cell physiology and lung…”
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TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells by Olbert, Peter J., M.D, Kesch, Claudia, M.D, Henrici, Marcus, M.D, Subtil, Florentine S., D.V.M, Honacker, Astrid, M.D, Hegele, Axel, M.D, Hofmann, Rainer, M.D, Hänze, Jörg, Ph.D

“…Abstract Objectives Adjuvant immunotherapy of bladder cancer by instillation of bacillus Calmette-Guérin (BCG) is highly recommended within certain groups of…”
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Irradiation-Dependent Effects on Tumor Perfusion and Endogenous and Exogenous Hypoxia Markers in an A549 Xenograft Model by Fokas, Emmanouil, M.D, Hänze, Jörg, Ph.D, Kamlah, Florentine, D.V.M, Eul, Bastian G., M.D, Lang, Nico, M.D, Keil, Boris, M.D, Heverhagen, Johannes T., M.D., Ph.D, Engenhart-Cabillic, Rita, M.D, An, Hanxiang, M.D, Rose, Frank, M.D

“…Purpose Hypoxia is a major determinant of tumor radiosensitivity, and microenvironmental changes in response to ionizing radiation (IR) are often heterogenous…”
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In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed by Eberle, Fabian, Leinberger, Florian H., Saulich, Miriam F., Seeger, Werner, Engenhart-Cabillic, Rita, Hänze, Jörg, Hattar, Katja, Dikomey, Ekkehard, Subtil, Florentine S.B.

“…The SCF/c-Kit pathway is often overexpressed in human tumors leading to an enhanced tumorigenesis, proliferation and migration. It was now tested for NSCLC and…”
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Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells‐role of hypoxia‐inducible transcription factors by Rose, Frank, Grimminger, Friedrich, Appel, Jutta, Heller, Mathias, Pies, Volker, Weissmann, Norbert, Fink, Ludger, Schmidt, Sebastian, Krick, Stefanie, Camenisch, Gieri, Gassmann, Max, Seeger, Werner, Hänze, Jörg

“…ABSTRACT Chronic lung hypoxia causes vascular remodeling with pulmonary artery smooth muscle cell (SMCPA) hyperplasia, resulting in pulmonary hypertension and…”
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Increase of endothelial nitric oxide synthase and endothelin-1 mRNA expression in human placenta during gestation by Dötsch, Jörg, Hogen, Naemi, Nyúl, Zoltan, Hänze, Jörg, Knerr, Ina, Kirschbaum, Michael, Rascher, Wolfgang

“…Objective: To investigate the maturation of the paracrine system’s endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), endothelin-1 (ET-1) and…”
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Soluble PD-L1 in blood correlates positively with neutrophil and negatively with lymphocyte mRNA markers and implies adverse sepsis outcome by Derigs, Marcus, Heers, Hendrik, Lingelbach, Susanne, Hofmann, Rainer, Hänze, Jörg

“…Sepsis causes a myriad of immunological reactions that result in life-threatening alterations in the human body. Immunosuppression in sepsis is partly…”
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Modulation of immune checkpoint regulators in interferon γ induced urothelial carcinoma and activated T-lymphocyte cells by cytostatics by Hänze, Jörg, Schulte-Herbrüggen, Johannes, Hofmann, Rainer, Hegele, Axel

“…Exploring the regulation of co-inhibitory (PD-1, PD-L1, CTLA-4) and co-stimulatory (CD28) genes by chemotherapeutic drugs is important for combined immune…”
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HIF-1α signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells by Malec, Viktor, Gottschald, Oana R., Li, Shu, Rose, Frank, Seeger, Werner, Hänze, Jörg

“…Fluctuations in cellular oxygenation causing intermittent hypoxia and oxidative stress affect the regulation of hypoxia-inducible factor (HIF-1) and the…”
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Gene expression of neuronal nitric oxide synthase and adrenomedullin in human neuroblastoma using real‐time PCR by Dötsch, Jörg, Harmjanz, Arndt, Christiansen, Holger, Hänze, Jörg, Lampert, Fritz, Rascher, Wolfgang

“…The objective of our study was to assess the gene expression of the antiproliferative systems neuronal nitric oxide synthase (nNOS) and adrenomedullin (AM) in…”
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Cellular and soluble immune checkpoint signaling forms PD-L1 and PD-1 in renal tumor tissue and in blood by Keber, Corinna U., Derigs, Marcus, Schultz, Carolin, Wegner, Moritz, Lingelbach, Susanne, Wischmann, Viktoria, Hofmann, Rainer, Denkert, Carsten, Hegele, Axel, Hänze, Jörg

“…Immune checkpoint blockade therapy is a treatment option of various metastatic cancer diseases including renal cell carcinoma (RCC). Approved antibody drugs…”
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Effects of multi and selective targeted tyrosine kinase inhibitors on function and signaling of different bladder cancer cells by Hänze, Jörg, Kessel, Friederike, Di Fazio, Pietro, Hofmann, Rainer, Hegele, Axel

“…[Display omitted] •mRNA analysis of RTK-signaling, proliferation and apoptosis separate bladder cancer cells in epithelial and mesenchymal like clusters.•The…”
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The Immune Checkpoint Molecule CD200 Is Associated with Tumor Grading and Metastasis in Bladder Cancer by Rexin, Peter, Tauchert, Alessa, Hänze, Jörg, Heers, Hendrik, Schmidt, Ansgar, Hofmann, Rainer, Hegele, Axel

“…We examined the expression of CD200, a ligand of immune tolerance, in transitional cell carcinoma of the human bladder (TCC). CD200 was analyzed by…”
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Prostate cancer tissues with positive TMPRSS2-ERG-gene-fusion status may display enhanced nerve density by Hänze, Jörg, Rexin, Peter, Jakubowski, Peter, Schreiber, Henner, Heers, Hendrik, Lingelbach, Susanne, Kinscherf, Ralf, Weihe, Eberhard, Hofmann, Rainer, Hegele, Axel

“…Innervation of prostate cancer (CaP) tissue favors tumor progression and metastasis but the regulation of innervation in CaP is unclear. The oncogenic…”
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