Search Results - "Hać, Aleksandra"

Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2'-deoxyuridine by Zdrowowicz, Magdalena, Spisz, Paulina, Hać, Aleksandra, Herman-Antosiewicz, Anna, Rak, Janusz

“…Radiotherapy is a crucial cancer treatment, but its outcome is still far from satisfactory. One of the reasons that cancer cells show resistance to ionizing…”
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Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells by Pawlik, Anna, Wała, Marta, Hać, Aleksandra, Felczykowska, Agnieszka, Herman-Antosiewicz, Anna

“…Isothiocyanates derived from the Brassicaceae plants possess chemopreventive and anticancer activities. One of them is sulforaphene (SF), which is abundant in…”
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Searching for relationships between the structure of selected simple coumarins, their antioxidant capacity and anticancer properties by Hać, Aleksandra, Milaș, Dan, Dziubek, Filip, Łomeć, Marta, Herman-Antosiewicz, Anna, Żamojć, Krzysztof

“…•The antioxidant capacity of simple coumarins studied by ABTS, CUPRAC, and FRAP.•The anticancer activity evaluated by MTT test on different cancer cell…”
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S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux by Hać, Aleksandra, Pierzynowska, Karolina, Herman-Antosiewicz, Anna

“…Autophagy is a specific macromolecule and organelle degradation process. The target macromolecule or organelle is first enclosed in an autophagosome, and then…”
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Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials by Małuch, Izabela, Stachurski, Oktawian, Kosikowska-Adamus, Paulina, Makowska, Marta, Bauer, Marta, Wyrzykowski, Dariusz, Hać, Aleksandra, Kamysz, Wojciech, Deptuła, Milena, Pikuła, Michał, Sikorska, Emilia

“…Antimicrobial peptides (AMPs) constitute a promising tool in the development of novel therapeutic agents useful in a wide range of bacterial and fungal…”
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Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics by Stachurski, Oktawian, Neubauer, Damian, Walewska, Aleksandra, Iłowska, Emilia, Bauer, Marta, Bartoszewska, Sylwia, Sikora, Karol, Hać, Aleksandra, Wyrzykowski, Dariusz, Prahl, Adam, Kamysz, Wojciech, Sikorska, Emilia

“…This study investigates short cationic antimicrobial lipopeptides composed of 2–4 amino acid residues and C12-C18 fatty acids attached to the N-terminal part…”
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Correction to Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells by Pyrczak-Felczykowska, Agnieszka, Narlawar, Rajeshwar, Pawlik, Anna, Guzow-Krzemińska, Beata, Artymiuk, Damian, Hać, Aleksandra, Ryś, Kamil, Rendina, Louis M, Reekie, Tristan A, Herman-Antosiewicz, Anna, Kassiou, Michael

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Imunofan-RDKVYR Peptide-Stimulates Skin Cell Proliferation and Promotes Tissue Repair by Sawicka, Justyna, Dzierżyńska, Maria, Wardowska, Anna, Deptuła, Milena, Rogujski, Piotr, Sosnowski, Paweł, Filipowicz, Natalia, Mieczkowska, Alina, Sass, Piotr, Pawlik, Anna, Hać, Aleksandra, Schumacher, Adriana, Gucwa, Magdalena, Karska, Natalia, Kamińska, Jolanta, Płatek, Rafał, Mazuryk, Jarosław, Zieliński, Jacek, Kondej, Karolina, Młynarz, Piotr, Mucha, Piotr, Skowron, Piotr, Janus, Łukasz, Herman-Antosiewicz, Anna, Sachadyn, Paweł, Czupryn, Artur, Piotrowski, Arkadiusz, Pikuła, Michał, Rodziewicz-Motowidło, Sylwia

“…Regeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding…”
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Mechanism of selective anticancer activity of isothiocyanates relies on differences in DNA damage repair between cancer and healthy cells by Hać, Aleksandra, Brokowska, Joanna, Rintz, Estera, Bartkowski, Michał, Węgrzyn, Grzegorz, Herman-Antosiewicz, Anna

“…Purpose Isothiocyanates (ITCs) are compounds derived from Brassica plants with documented anticancer activity. Molecular mechanisms of their selective activity…”
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Correction of Huntington’s Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model by Pierzynowska, Karolina, Gaffke, Lidia, Hać, Aleksandra, Mantej, Jagoda, Niedziałek, Natalia, Brokowska, Joanna, Węgrzyn, Grzegorz

“…Huntington’s disease (HD) is a monogenic disorder, caused by mutations in the HTT gene which result in expansion of CAG triplets. The product of the mutated…”
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Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells by Pyrczak-Felczykowska, Agnieszka, Narlawar, Rajeshwar, Pawlik, Anna, Guzow-Krzemińska, Beata, Artymiuk, Damian, Hać, Aleksandra, Ryś, Kamil, Rendina, Louis M, Reekie, Tristan A, Herman-Antosiewicz, Anna, Kassiou, Michael

“…Usnic acid is a secondary metabolite abundantly found in lichens, for which promising cytotoxic and antitumor potential has been shown. However, knowledge…”
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The Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells That Leads to Paraptosis-like Cell Death by Pyrczak-Felczykowska, Agnieszka, Reekie, Tristan A, Jąkalski, Marcin, Hać, Aleksandra, Malinowska, Marcelina, Pawlik, Anna, Ryś, Kamil, Guzow-Krzemińska, Beata, Herman-Antosiewicz, Anna

“…Derivatives of usnic acid (UA), a secondary metabolite from lichens, were synthesized to improve its anticancer activity and selectivity. Recently we reported…”
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The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo by Gimła, Mariola, Pyrczak-Felczykowska, Agnieszka, Malinowska, Marcelina, Hać, Aleksandra, Narajczyk, Magdalena, Bylińska, Irena, Reekie, Tristan A., Herman-Antosiewicz, Anna

“…Abstract Background Pancreatic cancer is one of the leading causes of cancer death in Western societies. Its late diagnosis and resistance to chemotherapies…”
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Dihydroxy-Substituted Coumarins as Fluorescent Probes for Nanomolar-Level Detection of the 4-Amino-TEMPO Spin Label by Żamojć, Krzysztof, Zdrowowicz, Magdalena, Hać, Aleksandra, Witwicki, Maciej, Rudnicki-Velasquez, Paweł Błażej, Wyrzykowski, Dariusz, Wiczk, Wiesław, Chmurzyński, Lech

“…This paper reports on dihydroxycoumarins as fluorescent probes suitable for the detection and determination of the nitroxide radical, namely 4-amino-TEMPO…”
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S6K1 controls autophagosome maturation in autophagy induced by sulforaphane or serum deprivation by Hać, Aleksandra, Domachowska, Anna, Narajczyk, Magdalena, Cyske, Karolina, Pawlik, Anna, Herman-Antosiewicz, Anna

“…It is well established that mTORC1 suppresses autophagy by phosphorylation and inactivation of proteins involved in autophagosome formation. However, the role…”
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L12 Sulforaphane reduces the level of exogenous mutated huntingtin protein in normal human fibroblasts by Brokowska, Joanna, Hać, Aleksandra, Węgrzyn, Grzegorz, Herman-Antosiewicz, Anna

“…Accumulation of mutated huntingtin aggregates in cells is the main cause of Huntington’s disease. Autophagy allows for removing protein aggregates and prevents…”
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Cytotoxicity of doxorubicin conjugated with C60 fullerene. Structural and in vitro studies by Butowska, Kamila, Kozak, Witold, Zdrowowicz, Magdalena, Makurat, Samanta, Rychłowski, Michał, Hać, Aleksandra, Herman-Antosiewicz, Anna, Piosik, Jacek, Rak, Janusz

“…Conjugating an anticancer drug of high biological efficacy but large cytotoxicity with a “transporting” molecule of low toxicity constitutes a valuable…”
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Functions of lysosomes are impaired during prolonged stress conditions in cells devoid of S6K1/2 by Hac, Aleksandra, Pierzynowska, Karolina, Herman-Antosiewicz, Anna

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L11 A novel approach for treatment of huntington’s disease by genistein-mediated stimulation of autophagy by Pierzynowska, Karolina, Hac, Aleksandra, Baranska, Sylwia, Wegrzyn, Grzegorz

“…BackgroundExpansions of CAG codons in the first exon of the HTT gene, encoding huntingtin, result in production of the protein that forms aggregates in cells,…”
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Sulfpraphane induces autophagy and reduces the level of mutated huntingtin in human fibroblasts by Brokowska, Joanna, Hac, Aleksandra, Wegrzyn, Grzegorz, Herman-Antosiewicz, Anna

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