Search Results - "Ha, Joseph H"

Ex Vivo Drug Screening Assay with Artificial Membranes: Characterizing Cholesterol Desorbing Competencies of Beta-Cyclodextrins by Al-Husseini, Jacob K., Fong, Ethan M., Wang, Chris, Ha, Joseph H., Upreti, Meenakshi, Chiarelli, Peter A., Johal, Malkiat S.

“…Despite advancements in contemporary therapies, cardiovascular disease from atherosclerosis remains a leading cause of mortality worldwide. Supported lipid…”
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Quantitative noninvasive measurement of cerebrospinal fluid flow in shunted hydrocephalus by Ha, Joseph H, Borzage, Matthew T, Vanstrum, Erik B, Doyle, Eamon K, Upreti, Meenakshi, Tamrazi, Benita, Nelson, Marvin, Blüml, Stefan, Johal, Malkiat S, McComb, J Gordon, Chu, Jason, Durham, Susan, Krieger, Mark D, Moats, Rex A, Chiarelli, Peter A

“…Standard MRI protocols lack a quantitative sequence that can be used to evaluate shunt-treated patients with a history of hydrocephalus. The objective of this…”
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The many faces of ubiquitinated histone H2A: insights from the DUBs by Vissers, Joseph Ha, Nicassio, Francesco, van Lohuizen, Maarten, Di Fiore, Pier Paolo, Citterio, Elisabetta

“…Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in…”
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The Future of Sensitivity Analysis: An essential discipline for systems modeling and policy support by Razavi, Saman, Jakeman, Anthony, Saltelli, Andrea, Prieur, Clémentine, Iooss, Bertrand, Borgonovo, Emanuele, Plischke, Elmar, Lo Piano, Samuele, Iwanaga, Takuya, Becker, William, Tarantola, Stefano, Guillaume, Joseph H.A., Jakeman, John, Gupta, Hoshin, Melillo, Nicola, Rabitti, Giovanni, Chabridon, Vincent, Duan, Qingyun, Sun, Xifu, Smith, Stefán, Sheikholeslami, Razi, Hosseini, Nasim, Asadzadeh, Masoud, Puy, Arnald, Kucherenko, Sergei, Maier, Holger R.

“…Sensitivity analysis (SA) is en route to becoming an integral part of mathematical modeling. The tremendous potential benefits of SA are, however, yet to be…”
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A methodology for eliciting, representing, and analysing stakeholder knowledge for decision making on complex socio-ecological systems: From cognitive maps to agent-based models by Elsawah, Sondoss, Guillaume, Joseph H.A., Filatova, Tatiana, Rook, Josefine, Jakeman, Anthony J.

“…This paper aims to contribute to developing better ways for incorporating essential human elements in decision making processes for modelling of complex…”
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Introductory overview of identifiability analysis: A guide to evaluating whether you have the right type of data for your modeling purpose by Guillaume, Joseph H.A., Jakeman, John D., Marsili-Libelli, Stefano, Asher, Michael, Brunner, Philip, Croke, Barry, Hill, Mary C., Jakeman, Anthony J., Keesman, Karel J., Razavi, Saman, Stigter, Johannes D.

“…Identifiability is a fundamental concept in parameter estimation, and therefore key to the large majority of environmental modeling applications. Parameter…”
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Integrated assessment and modelling: Overview and synthesis of salient dimensions by Hamilton, Serena H., ElSawah, Sondoss, Guillaume, Joseph H.A., Jakeman, Anthony J., Pierce, Suzanne A.

“…Integrated assessment and its inherent platform, integrated modelling, present an opportunity to synthesize diverse knowledge, data, methods and perspectives…”
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Considering scale within optimization procedures for water management decisions: Balancing environmental flows and human needs by Derepasko, Diana, Guillaume, Joseph H.A., Horne, Avril C., Volk, Martin

“…A key issue in optimization model development is the selection of spatial and temporal scale representing the system. This study proposes a framework for…”
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Reflective communication to improve problem-solving pathways: Key issues illustrated for an integrated environmental modelling case study by Zare, Fateme, Guillaume, Joseph H.A., Jakeman, Anthony J., Torabi, Oveis

“…The pathway of a modelling project is commonly described as an adaptively adjusted chain of steps at which various decisions are made. Communication and…”
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A framework for characterising and evaluating the effectiveness of environmental modelling by Hamilton, Serena H., Fu, Baihua, Guillaume, Joseph H.A., Badham, Jennifer, Elsawah, Sondoss, Gober, Patricia, Hunt, Randall J., Iwanaga, Takuya, Jakeman, Anthony J., Ames, Daniel P., Curtis, Allan, Hill, Mary C., Pierce, Suzanne A., Zare, Fateme

“…Environmental modelling is transitioning from the traditional paradigm that focuses on the model and its quantitative performance to a more holistic paradigm…”
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Quantitative Non-Invasive Measurement of Cerebrospinal Fluid Flow in Shunted Hydrocephalus by Ha, Joseph H., Borzage, Matthew T., Vanstrum, Erik B., Doyle, Eamon K., Upreti, Meenakshi, Tamrazi, Benita, Nelson, Marvin, Blüml, Stefan, Johal, Malkiat S., McComb, J. Gordon, Chu, Jason, Moats, Rex A., Chiarelli, Peter A.

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Effective modeling for Integrated Water Resource Management: A guide to contextual practices by phases and steps and future opportunities by Badham, Jennifer, Elsawah, Sondoss, Guillaume, Joseph H.A., Hamilton, Serena H., Hunt, Randall J., Jakeman, Anthony J., Pierce, Suzanne A., Snow, Valerie O., Babbar-Sebens, Meghna, Fu, Baihua, Gober, Patricia, Hill, Mary C., Iwanaga, Takuya, Loucks, Daniel P., Merritt, Wendy S., Peckham, Scott D., Richmond, Amy K., Zare, Fateme, Ames, Daniel, Bammer, Gabriele

“…The effectiveness of Integrated Water Resource Management (IWRM) modeling hinges on the quality of practices employed through the process, starting from early…”
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Assessing the predictive impact of factor fixing with an adaptive uncertainty-based approach by Wang, Qian, Guillaume, Joseph H.A., Jakeman, John D., Yang, Tao, Iwanaga, Takuya, Croke, Barry, Jakeman, Anthony J.

“…Despite widespread use of factor fixing in environmental modeling, its effect on model predictions has received little attention and is instead commonly…”
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Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription by Kulkarni, Aishwarya, Mohan, Varshini, Tang, Tracy T, Post, Leonard, Chan, Yih-Chih, Manning, Murray, Thio, Niko, Parker, Benjamin L, Dawson, Mark A, Rosenbluh, Joseph, Vissers, Joseph HA, Harvey, Kieran F

“…The Hippo tumor suppressor pathway controls transcription by regulating nuclear abundance of YAP and TAZ, which activate transcription with the TEAD1-TEAD4…”
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The emerging role of Polycomb repressors in the response to DNA damage by Vissers, Joseph H A, van Lohuizen, Maarten, Citterio, Elisabetta

“…Polycomb group (PcG) genes encode chromatin modifiers that are involved in the maintenance of cell identity and in proliferation, processes that are often…”
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A review of foundational methods for checking the structural identifiability of models: Results for rainfall-runoff by Shin, Mun-Ju, Guillaume, Joseph H.A., Croke, Barry F.W., Jakeman, Anthony J.

“…•Four screening methods have roles to play in understanding the non-identifiability.•Evolutionary algorithms can experience difficulties in convergence.•Model…”
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Bringing it all together: linking measures to secure nations’ food supply by Kummu, Matti, Fader, Marianela, Gerten, Dieter, Guillaume, Joseph HA, Jalava, Mika, Jägermeyr, Jonas, Pfister, Stephan, Porkka, Miina, Siebert, Stefan, Varis, Olli

“…[Display omitted] •We review literature and integrate estimations of diet change, food loss reduction and yield gap closure potentials at the country…”
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From ad-hoc modelling to strategic infrastructure: A manifesto for model management by Arnold, Thorsten, Guillaume, Joseph H.A., Lahtinen, Tuomas J., Vervoort, R. Willem

“…Models are playing an increasingly prominent role in watershed management, and environmental management more generally. To successfully utilize model-based…”
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Property-based Sensitivity Analysis: An approach to identify model implementation and integration errors by Iwanaga, Takuya, Sun, Xifu, Wang, Qian, Guillaume, Joseph H.A., Croke, Barry F.W., Rahman, Joel, Jakeman, Anthony J.

“…Diagnostic testing is an oft-recommended use of sensitivity analysis to assess correctness or plausibility of model behavior. In this paper we demonstrate the…”
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Remotely sensed evapotranspiration to calibrate a lumped conceptual model: Pitfalls and opportunities by Willem Vervoort, R., Miechels, Susannah F., van Ogtrop, Floris F., Guillaume, Joseph H.A.

“…•New satellite ET data offers opportunities for model parameter and structure identifiability.•Model performance reduces, adding MODIS ET as a calibration set,…”
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