Search Results - "Ha, Jae Du"

Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC) by Kang, Chung Hyo, Lee, Dong Ho, Lee, Chong Ock, Du Ha, Jae, Park, Chi Hoon, Hwang, Jong Yeon

“…Recently, proteolysis targeting chimera (PROTAC) technology is highlighted in drug discovery area as a new therapeutic approach. PROTAC as a heterobifunctional…”
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Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras by Takwale, Akshay D., Jo, Seung-Hyun, Jeon, Yeong Uk, Kim, Hyung Soo, Shin, Choong Hoon, Lee, Heung Kyoung, Ahn, Sunjoo, Lee, Chong Ock, Du Ha, Jae, Kim, Jeong-Hoon, Hwang, Jong Yeon

“…Proteolysis-targeting chimera (PROTAC)-mediated protein degradation is a rapidly emerging therapeutic intervention that induces the degradation of targeted…”
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Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma by Park, Sungryul, Jo, Seung-Hyun, Kim, Jong-Hwan, Kim, Seon-Young, Ha, Jae Du, Hwang, Jong Yeon, Lee, Myeong Youl, Kang, Jong Soon, Han, Tae-Su, Park, Sung Goo, Kim, Sunhong, Park, Byoung Chul, Kim, Jeong-Hoon

“…Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), regulates genes involved in…”
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Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors by Ahn, Jin Hee, Kim, Seung Jun, Park, Woul Seong, Cho, Sung Yun, Ha, Jae Du, Kim, Sung Soo, Kang, Seung Kyu, Jeong, Dae Gwin, Jung, Suk-Kyeong, Lee, Sang-Hyeup, Kim, Hwan Mook, Park, Song Kyu, Lee, Ki Ho, Lee, Chang Woo, Ryu, Seong Eon, Choi, Joong-Kwon

“…A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological…”
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Augmentation of the antitumor effects of PARP inhibitors in triple-negative breast cancer via degradation by hydrophobic tagging modulation by Go, Ahra, Jang, Jeong Woon, Lee, Woori, Ha, Jae Du, Kim, Hyun Jin, Nam, Hye Jin

“…Triple-negative breast cancer (TNBC) has an aggressive phenotype and poor prognosis due to the lack of specific targeted treatments. The development of an…”
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Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors by Lee, Jongkook, Han, Sun-Young, Jung, Heejung, Yang, Jeon, Choi, Jie-Won, Chae, Chong Hack, Park, Chi Hoon, Choi, Sang Un, Lee, Kwangho, Ha, Jae Du, Lee, Chong Ock, Ryu, Jae Wook, Kim, Hyoung Rae, Koh, Jong Sung, Cho, Sung Yun

“…A series of hydroxybenzoxazole derivatives was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met…”
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Cereblon contributes to cardiac dysfunction by degrading Cav1.2α by Park, Nammi, Marquez, Jubert, Pham, Trong Kha, Ko, Tae Hee, Youm, Jae Boum, Kim, Min, Choi, Seung Hak, Moon, Jiyoung, Flores, Jessa, Ko, Kyung Soo, Rhee, Byoung Doo, Shimizu, Ippei, Minamino, Tohru, Ha, Jae Du, Hwang, Jong Yeon, Yang, Seung Joo, Park, Chul-Seung, Kim, Hyoung Kyu, Han, Jin

“…Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that was reported to target ion channel proteins. L-type voltage-dependent Ca2+…”
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Design and Synthesis of Novel 3-(2-Aminopyridin-3-yl)-1,2,4-Triazolo [4,3-b]Pyridazine Derivatives as a Reversible Bruton's Tyrosine Kinase Inhibitors by Park, Chi Hoon, Kim, Dukwoon, Jung, Hyeonseok, Jeon, Jeong Hee, Achary, Raghavendra, Lee, Joo-Youn, Kim, Pilho, Jung, Heejung, Hwang, Jong Yeon, Ryu, Do Hyun, Ha, Jae Du, Cho, Sung Yun

“…Bruton's tyrosine kinase, a non-receptor TEC family kinase, plays key role in B cell differentiation, proliferation, and survival. B cell receptor regulates…”
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A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication by Kim, Jinwoo, Jung, Yu Kyoung, Kim, Chonsaeng, Shin, Jin Soo, Scheers, Els, Lee, Joo-Youn, Han, Soo Bong, Lee, Chong-Kyo, Neyts, Johan, Ha, Jae-Du, Jung, Young-Sik

“…Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV…”
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Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors by Cho, Sung Yun, Han, Sun-Young, Ha, Jae Du, Ryu, Jae Wook, Lee, Chong Ock, Jung, Heejung, Kang, Nam Sook, Kim, Hyoung Rae, Koh, Jong Sung, Lee, Jongkook

“…A series of aminopyridines substituted with benzoxazole were designed and synthesized as very potent c-Met kinase inhibitors. We report the synthesis and…”
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Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera by Kim, Kidae, Lee, Dong Ho, Park, Sungryul, Jo, Seung-Hyun, Ku, Bonsu, Park, Sung Goo, Park, Byoung Chul, Jeon, Yeong Uk, Ahn, Sunjoo, Kang, Chung Hyo, Hwang, Daehee, Chae, Sehyun, Ha, Jae Du, Kim, Sunhong, Hwang, Jong Yeon, Kim, Jeong-Hoon

“…Proteolysis targeting chimeras (PROTACs) are an emerging strategy for promoting targeted protein degradation by inducing the proximity between targeted…”
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Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors by Ryu, Jae Wook, Han, Sun-Young, Yun, Jeong In, Choi, Sang-Un, Jung, Heejung, Ha, Jae Du, Cho, Sung Yun, Lee, Chong Ock, Kang, Nam Sook, Koh, Jong Sung, Kim, Hyoung Rae, Lee, Jongkook

“…A series of triazolopyridazines substituted with methylisoquinolinone were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met…”
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Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors by Park, Sun Jun, Kim, Eunjin, Yoo, Miyoun, Lee, Joo-Youn, Park, Chi Hoon, Hwang, Jong Yeon, Ha, Jae Du

“…[Display omitted] A novel 6-aminopurine scaffold bearing an N9-cis-cyclobutyl moiety was designed using structure-based molecular design based on two known CDK…”
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cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis by Choi, Jin Sun, Kim, Kidae, Lee, Do Hee, Cho, Sayeon, Ha, Jae Du, Park, Byoung Chul, Kim, Sunhong, Park, Sung Goo, Kim, Jeong-Hoon

“…Although the ubiquitin–proteasome system is believed to play an important role in the pathogenesis of familial amyotrophic lateral sclerosis (FALS), caused by…”
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Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor by Kang, Ga Ae, Lee, Minji, Song, Dawn, Lee, Heung Kyoung, Ahn, Sunjoo, Park, Chi Hoon, Lee, Chong Ock, Yun, Chang Soo, Jung, Heejung, Kim, Pilho, Ha, Jae Du, Cho, Sung Yun, Kim, Hyoung Rae, Hwang, Jong Yeon

“…[Display omitted] A series of novel 2,4-diaminopyrimidine compounds bearing bicyclic aminobenzazepine were synthesized and evaluated for their anti-ALK…”
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Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R by Mathi, Gangadhar Rao, Kang, Chung Hyo, Lee, Heung Kyoung, Achary, Raghavendra, Lee, Ha-Yeon, Lee, Joo-Youn, Ha, Jae Du, Ahn, Sunjoo, Park, Chi Hoon, Lee, Chong Ock, Hwang, Jong Yeon, Yun, Chang-Soo, Jung, Hee Jung, Cho, Sung Yun, Kim, Hyoung Rae, Kim, Pilho

“…The piperidine fragment in ceritinib was replaced with diverse aliphatic amines to improve inherent resistance issues of ceritinib. While most of the prepared…”
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4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors by Lim, Chae Jo, Oh, Kwang-Seok, Ha, Jae Du, Lee, Jeong Hyun, Seo, Ho Won, Chae, Chong Hack, Kim, Dae-Ghon, Lee, Mi-Jin, Lee, Byung Ho

“…Erythropoietin-producing hepatocellular receptor tyrosine kinase subtype A2 (EphA2) is an attractive therapeutic target for suppressing tumor progression. In…”
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Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors by Cho, Sung Yun, Lee, Byung Ho, Jung, Heejung, Yun, Chang Soo, Ha, Jae Du, Kim, Hyoung Rae, Chae, Chong Hak, Lee, Jeong Hyun, Seo, Ho Won, Oh, Kwang-Seok

“…G-protein-coupled receptor kinase (GRK)-2 and -5 are emerging therapeutic targets for the treatment of cardiovascular disease. In our efforts to discover novel…”
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Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment by Park, Chi Hoon, Choe, Hyeonjeong, Jang, In-Young, Kwon, So Yeong, Latif, Muhammad, Lee, Heung Kyoung, Lee, Hyeon Ji, Yang, Eun Hye, Yun, Jeong In, Chae, Chong Hak, Cho, Sung Yun, Choi, Sang Un, Ha, Jae Du, Jung, Heejung, Kim, Hyoung Rae, Kim, Pilho, Lee, Chong Ock, Yun, Chang-Soo, Lee, Kwangho

“…The synthesis of bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines is described and their structure–activity-relationship to anaplastic…”
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Synthesis and characterization of novel polyimides with 1-octadecyl side chains for liquid crystal alignment layers by Lee, Yoon Jung, Kim, Yong Woon, Ha, Jae Du, Oh, Jae Min, Yi, Mi Hye

“…A series of poly(amic acid)s have been synthesized from cyclobutane‐1,2,3,4‐tetracarboxylic dianhydride (CBDA), a functional diamine,…”
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