Effects of Ionized Alkali Water Intake on Oxidative Stress Induced by Exhaustive Treadmill Exercise
PURPOSE: To investigate the effects of ionized alkali water (IAW) intake on oxidative stress and its related genes expression in highly trained athletes. METHODS: In a single group and crossover design, 18 middle distance runners (mean age 17.9+ or -0.9 yrs, BMI 22.4+ or -1.2 kg/m super(2), VO2max 6...
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| Published in: | Medicine and science in sports and exercise Vol. 44; no. 5S; p. 216 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-05-2012
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| Online Access: | Get full text |
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| Summary: | PURPOSE: To investigate the effects of ionized alkali water (IAW) intake on oxidative stress and its related genes expression in highly trained athletes. METHODS: In a single group and crossover design, 18 middle distance runners (mean age 17.9+ or -0.9 yrs, BMI 22.4+ or -1.2 kg/m super(2), VO2max 65.6+ or -5.0 ml/kg/min) consumed tap water (TW) and IAW (pH 9.8+ or -0.3) for 2 weeks, respectively, in a random order, and one week was allowed between each trial. After each trial, the subjects underwent an acute and exhaustive treadmill running at an intensity of 80% VO2max. Venous blood samples were collected prior to and immediately after the treadmill running and 2-hr and 24-hr post-exercise periods. Blood samples were used to measure serum concentrations for malondialdehyde (MDA), tumor necrosis factor (TNF)- alpha and interleukin (IL)-6. RelA (p65) protein, inducible NO synthase (iNOS) mRNA, cyclooxygenase (COX) 2 mRNA and IL-6 mRNA were also measured in peripheral blood mononuclear cells. RESULTS: At the baseline, there was a tendency for serum IL-6 concentration to be lower (p=0.063) with the IAW trial (0.36+ or -0.21 pg/dl) than that of the TW trial (0.62+ or -0.53 pg/dl), with no significant differences in MDA (p=0.585) and TNF- alpha (p=0.349) between the trials. At the 2-hr (TW 2.70+ or -0.77 vs. IAW 2.14+ or -0.35 umol/dl) and 24-hr (TW 2.34+ or -0.58 vs. IAW 1.94+ or -0.40 umol/dl) post-exercise periods, serum MDA levels were significantly lower (p=0.002 & p=0.016, respectively) in the IAW trial than those of the TW trial. At the 0-hr post-exercise period, p65 protein level was significantly lower (p=0.046) in the IAW trial than that of the TW trial. No significant time by trial interactions were found for serum TNF alpha and IL-6 levels. CONCLUSION: The findings of the study suggest that IAW intake can induce somewhat anti-oxidant effect against free radicals and reactive oxygen species occurring during exhaustive exercise and/or training. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
| ISSN: | 0195-9131 |