Search Results - "HYUG MOO KWON"
-
1
TonEBP inhibits ciliogenesis by controlling aurora kinase A and regulating centriolar satellite integrity
Published in Cell communication and signaling (03-07-2024)“…Primary cilia on the surface of eukaryotic cells serve as sensory antennas for the reception and transmission in various cell signaling pathways. They are…”
Get full text
Journal Article -
2
Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy
Published in International journal of ophthalmology (18-12-2014)“…To study the contribution of tonicity response element binding protein (TonEBP) in retinal ganglion cell (RGC) death of diabetic retinopathy (DR). Diabetes was…”
Get full text
Journal Article -
3
Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-κB and AP-1
Published in Journal of neuroinflammation (08-12-2020)“…Abstract Background Microglia are brain-resident myeloid cells involved in the innate immune response and a variety of neurodegenerative diseases. In…”
Get full text
Journal Article -
4
Elevated Activity of Transcription Factor Nuclear Factor of Activated T-Cells 5 (NFAT5) and Diabetic Nephropathy
Published in Diabetes (New York, N.Y.) (01-05-2006)“…Elevated Activity of Transcription Factor Nuclear Factor of Activated T-Cells 5 (NFAT5) and Diabetic Nephropathy Bingmei Yang 1 , Andrea D. Hodgkinson 1 ,…”
Get full text
Journal Article -
5
Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome-lysosome fusion
Published in Cell communication and signaling (25-11-2022)“…Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE…”
Get full text
Journal Article -
6
Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury
Published in Journal of the American Society of Nephrology (01-02-2018)“…Diabetic nephropathy (DN) has become the single leading cause of ESRD in developed nations. Bearing in mind the paucity of effective treatment for DN and…”
Get full text
Journal Article -
7
TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions
Published in Cell communication and signaling (21-02-2024)“…Calcium is a ubiquitous intracellular messenger that regulates the expression of various genes involved in cell proliferation, differentiation, and motility…”
Get full text
Journal Article -
8
TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
Published in Nature communications (06-08-2019)“…Tonicity-responsive enhancer binding protein (TonEBP or NFAT5) is a regulator of cellular adaptation to hypertonicity, macrophage activation and T-cell…”
Get full text
Journal Article -
9
Catalase-deficient mice induce aging faster through lysosomal dysfunction
Published in Cell communication and signaling (06-12-2022)“…Lysosomes are a central hub for cellular metabolism and are involved in the regulation of cell homeostasis through the degradation or recycling of unwanted or…”
Get full text
Journal Article -
10
Roles of fluid shear stress and retinoic acid in the differentiation of primary cultured human podocytes
Published in Experimental cell research (01-05-2017)“…Due to the distinct features that distinguish immortalized podocyte cell lines from their in vivo counterparts, primary cultured human podocytes might be a…”
Get full text
Journal Article -
11
TAZ Suppresses NFAT5 Activity through Tyrosine Phosphorylation
Published in Molecular and Cellular Biology (01-12-2012)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
12
A Gain-of-Function Cleavage of TonEBP by Coronavirus NSP5 to Suppress IFN-β Expression
Published in Cells (Basel, Switzerland) (26-09-2024)“…Human coronaviruses (HCoVs) modify host proteins to evade the antiviral defense and sustain viral expansion. Here, we report tonicity-responsive enhancer…”
Get full text
Journal Article -
13
TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
Published in Frontiers in immunology (18-04-2019)“…TonEBP is a key transcriptional activator in macrophages with an M1 phenotype. High expression of TonEBP is associated with many inflammatory diseases. Heme…”
Get full text
Journal Article -
14
TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPARγ2
Published in Scientific reports (04-06-2015)“…TonEBP is a key transcription factor in cellular adaptation to hypertonic stress and also in macrophage activation. Since TonEBP is involved in inflammatory…”
Get full text
Journal Article -
15
Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance
Published in EBioMedicine (01-08-2020)“…High recurrence and chemoresistance drive the high mortality in hepatocellular carcinoma (HCC). Although cancer stem cells are considered to be the source of…”
Get full text
Journal Article -
16
Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes
Published in Experimental & molecular medicine (01-07-2013)“…The activation of nuclear factor of activated T cells 5 (NFAT5), a well-known osmoprotective factor, can be induced by isotonic stimuli, such as activated…”
Get full text
Journal Article -
17
TonEBP and SMIT expression in human placenta
Published in Anatomy & cell biology (30-09-2012)Get full text
Journal Article -
18
TonEBP Promotes β-Cell Survival under ER Stress by Enhancing Autophagy
Published in Cells (Basel, Switzerland) (20-08-2020)“…The endoplasmic reticulum (ER) stress response and autophagy are important cellular responses that determine cell fate and whose dysregulation is implicated in…”
Get full text
Journal Article -
19
TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
Published in iScience (27-09-2019)“…Polyubiquitination of proliferating cell nuclear antigen (PCNA) regulates the error-free template-switching mechanism for the bypass of DNA lesions during DNA…”
Get full text
Journal Article -
20
Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury
Published in Cells (Basel, Switzerland) (20-10-2019)“…TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress…”
Get full text
Journal Article