Search Results - "HYSLOP, Deborah K"

Synthesis and Biological Activities of (R)-5,6-Dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and Its Metabolites by Heier, Richard F, Dolak, Lester A, Duncan, J. Neil, Hyslop, Deborah K, Lipton, Michael F, Martin, Iain J, Mauragis, Michael A, Piercey, Montford F, Nichols, Nanette F, Schreur, Peggy J. K. D, Smith, Martin W, Moon, Malcolm W

“…The imidazoquinoline (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine [(R)-3] is a potent dopamine agonist when tested in animals but…”
Get full text

Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor by Wong, Erik H.F., Sonders, Mark S., Amara, Susan G., Tinholt, Paula M., Piercey, Montford F.P., Hoffmann, William P., Hyslop, Deborah K., Franklin, Stanley, Porsolt, Roger D., Bonsignori, Alberto, Carfagna, Nicola, McArthur, Robert A.

“…Background: Reboxetine is a potent antidepressant, with efficacy comparable to that of imipramine, desipramine, and fluoxetine, and has improved side-effect…”
Get full text

Inhibition of dopamine neuron firing by pramipexole, a dopamine D3 receptor-preferring agonist : comparison to other dopamine receptor agonists by PIERCEY, M. F, HOFFMANN, W. E, SMITH, M. W, HYSLOP, D. K

“…Pramipexole, an amino-benzathiazole [(S)-4,5,6,7-tetrahydro-N-6-propyl-2, 6-benzothiazolediamine dihydrochloride monohydrate] direct-acting dopamine receptor…”
Get full text

2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: New templates for 5-HT2C agonists by ENNIS, Michael D, HOFFMAN, Robert L, SVENSSON, Kjell A, MCCALL, Robert B, HABER, Christopher L, KAGEY, Michelle L, DINH, Dac M, GHAZAL, Nabil B, OLSON, Rebecca M, KNAUER, Christopher S, CHIO, Chris L, HYSLOP, Deborah K, CAMPBELL, Jeffery E, FITZGERALD, Lawrence W, NICHOLS, Nanette F

Get full text

Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase by Mottola, David M, Kilts, Jason D, Lewis, Mechelle M, Connery, Hilary S, Walker, Q David, Jones, Sara R, Booth, Raymond G, Hyslop, Deborah K, Piercey, Monford, Wightman, R Mark, Lawler, Cindy P, Nichols, David E, Mailman, Richard B

“…Dihydrexidine (DHX), the first high-affinity D(1) dopamine receptor full agonist, is only 10-fold selective for D(1) versus D(2) receptors, having D(2)…”
Get more information

Excitation of type II anterior caudate neurons by stimulation of dopamine D3 receptors by Piercey, M F, Hyslop, D K, Hoffmann, W E

“…Previous studies have demonstrated that both direct- and indirect-acting dopamine (DA) receptor agonists excite type II neurons in the anterior caudate (CN) by…”
Get full text

Inhibition of dopamine neuron firing by pramipexole, a dopamine D 3 receptor-preferring agonist: comparison to other dopamine receptor agonists by Piercey, Montford F., Hoffmann, William E., Smith, Martin W., Hyslop, Deborah K.

“…Pramipexole, an amino-benzathiazole [( S)-4,5,6,7-tetrahydro- N-6-propyl-2,6-benzothiazolediamine dihydrochloride monohydrate] direct-acting dopamine receptor…”
Get full text

2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists by Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, Olson, Rebecca M, Knauer, Christopher S, Chio, Chris L, Hyslop, Deborah K, Campbell, Jeffery E, Fitzgerald, Lawrence W, Nichols, Nanette F, Svensson, Kjell A, McCall, Robert B, Haber, Christopher L, Kagey, Michelle L, Dinh, Dac M

“…The design and synthesis of the novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole 5 is described. This azepinoindole has excellent affinity for 5-HT(2C)…”
Get full text

2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7- a]indoles: new templates for 5-HT 2C agonists by Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, Olson, Rebecca M, Knauer, Christopher S, Chio, Chris L, Hyslop, Deborah K, Campbell, Jeffery E, Fitzgerald, Lawrence W, Nichols, Nanette F, Svensson, Kjell A, McCall, Robert B, Haber, Christopher L, Kagey, Michelle L, Dinh, Dac M

“…The design and synthesis of the novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7- a]indole 5 is described. This azepinoindole has excellent affinity for 5-HT 2C…”
Get full text

Excitation of type II anterior caudate neurons by stimulation of dopamine D 3 receptors by Piercey, Montford F, Hyslop, Deborah K, Hoffmann, William E

“…Previous studies have demonstrated that both direct- and indirect-acting dopamine (DA) receptor agonists excite type II neurons in the anterior caudate (CN) by…”
Get full text

BMY 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-HT1A receptor in rat and guinea pig hippocampal membranes by Yocca, F D, Hyslop, D K, Smith, D W, Maayani, S

Get more information

Excitation of type II caudate neurons by systemic administration of dopamine agonists by Piercey, Montford F., Hyslop, Deborah K., Hoffmann, William E.

“…Using chloral hydrate anesthetized rats, dopamine (DA) agonists were evaluated for their systemic effects on firing rates of DA neurons in rat substantia nigra…”
Get full text

Synthesis and Biological Activities of ( R )-5,6-Dihydro- N , N -dimethyl-4 H -imidazo[4,5,1- ij ]quinolin-5-amine and Its Metabolites by Heier, Richard F., Dolak, Lester A., Duncan, J. Neil, Hyslop, Deborah K., Lipton, Michael F., Martin, Iain J., Mauragis, Michael A., Piercey, Montford F., Nichols, Nanette F., Schreur, Peggy J. K. D., Smith, Martin W., Moon, Malcolm W.

Get full text

Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment by Yocca, F D, Eison, A S, Hyslop, D K, Ryan, E, Taylor, D P, Gianutsos, G

“…The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was…”
Get more information

Effect of irreversible loss of muscarinic receptors on (3H)-acetylcholine release from the hippocampus by Sethy, V H, Hyslop, D K

“…The role of muscarinic receptors in the regulation of (3H)-acetylcholine (3H-Ach) release from the hippocampus was investigated with the irreversible…”
Get more information

Trazodone, a new nontricyclic antidepressant without anticholinergic activity by Taylor, D P, Hyslop, D K, Riblet, L A

Get more information

Radioreceptor assay of dopamine binding activity in human serum after tiospirone administration by Hyslop, D K, Westrick, M L, Shukla, U A, Taylor, D P

“…Tiospirone has demonstrated preclinical activities that predict utility as an antipsychotic drug which lacks the potential to produce extrapyramidal side…”
Get more information

THE INTERACTION OF TRAZODONE WITH RAT BRAIN MUSCARINIC CHOLINOCEPTORS by HYSLOP, DEBORAH K., TAYLOR, DUNCAN P.

“…The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to…”
Get full text

Treatment with trazodone plus phenoxybenzamine accelerates development of decreased type 2 serotonin binding in rat cortex by Taylor, D P, Allen, L E, Ashworth, E M, Becker, J A, Hyslop, D K, Riblet, L A

Get more information

Trazodone does not competitively inhibit binding at muscarinic cholinoceptors by Taylor, D P, Hyslop, D K, Becker, J A

Get more information