Search Results - "HYSI, Pirro"

Real-time tracking of self-reported symptoms to predict potential COVID-19 by Menni, Cristina, Valdes, Ana M., Freidin, Maxim B., Sudre, Carole H., Nguyen, Long H., Drew, David A., Ganesh, Sajaysurya, Varsavsky, Thomas, Cardoso, M. Jorge, El-Sayed Moustafa, Julia S., Visconti, Alessia, Hysi, Pirro, Bowyer, Ruth C. E., Mangino, Massimo, Falchi, Mario, Wolf, Jonathan, Ourselin, Sebastien, Chan, Andrew T., Steves, Claire J., Spector, Tim D.

“…A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2…”
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Prevalence and risk factors of dry eye disease in a British female cohort by Vehof, Jelle, Kozareva, Diana, Hysi, Pirro G, Hammond, Christopher J

“…To estimate the prevalence and risk factors of dry eye disease (DED) in a female cohort in the UK. Population-based cross-sectional association study of 3824…”
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Focusing in on the complex genetics of myopia by Wojciechowski, Robert, Hysi, Pirro G

“…  [...]the exact mechanisms through which these genes act to regulate ocular refraction are unknown, and current animal models may be inadequate to hypothesize…”
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The Slowly Emerging Uniqueness of the High Myopia Genetic Architecture by Patasova, Karina, Hysi, Pirro G

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Temporal trends in frequency, type and severity of myopia and associations with key environmental risk factors in the UK: Findings from the UK Biobank Study by Cumberland, Phillippa M, Bountziouka, Vasiliki, Hammond, Christopher J, Hysi, Pirro G, Rahi, Jugnoo S

“…This study investigated temporal trends in the epidemiology of primary myopia and associations with key environmental risk factors in a UK population. Data…”
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Heritability maps of human face morphology through large-scale automated three-dimensional phenotyping by Tsagkrasoulis, Dimosthenis, Hysi, Pirro, Spector, Tim, Montana, Giovanni

“…The human face is a complex trait under strong genetic control, as evidenced by the striking visual similarity between twins. Nevertheless, heritability…”
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Replication of SNP associations with keratoconus in a Czech cohort by Liskova, Petra, Dudakova, Lubica, Krepelova, Anna, Klema, Jiri, Hysi, Pirro G

“…Keratoconus is a relatively frequent disease leading to severe visual impairment. Existing therapies are imperfect and clinical management may benefit from…”
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A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers by Vehof, Jelle, MD, PhD, Hysi, Pirro G., MD, PhD, Hammond, Christopher J., MD, FRCOphth

“…Purpose To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach. Design Cross-sectional…”
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Frequency and Distribution of Refractive Error in Adult Life: Methodology and Findings of the UK Biobank Study by Cumberland, Phillippa M, Bao, Yanchun, Hysi, Pirro G, Foster, Paul J, Hammond, Christopher J, Rahi, Jugnoo S

“…To report the methodology and findings of a large scale investigation of burden and distribution of refractive error, from a contemporary and ethnically…”
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APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans by Tkatchenko, Andrei V, Tkatchenko, Tatiana V, Guggenheim, Jeremy A, Verhoeven, Virginie J M, Hysi, Pirro G, Wojciechowski, Robert, Singh, Pawan Kumar, Kumar, Ashok, Thinakaran, Gopal, Williams, Cathy

“…Myopia is the most common vision disorder and the leading cause of visual impairment worldwide. However, gene variants identified to date explain less than 10%…”
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Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma by Khawaja, Anthony P., Cooke Bailey, Jessica N., Wareham, Nicholas J., Scott, Robert A., Simcoe, Mark, Igo, Robert P., Song, Yeunjoo E., Wojciechowski, Robert, Cheng, Ching-Yu, Khaw, Peng T., Pasquale, Louis R., Haines, Jonathan L., Foster, Paul J., Wiggs, Janey L., Hammond, Chris J., Hysi, Pirro G.

“…Glaucoma is the leading cause of irreversible blindness globally 1 . Despite its gravity, the disease is frequently undiagnosed in the community 2 . Raised…”
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Artificial Intelligence Applied to Osteoporosis: A Performance Comparison of Machine Learning Algorithms in Predicting Fragility Fractures From MRI Data by Ferizi, Uran, Besser, Harrison, Hysi, Pirro, Jacobs, Joseph, Rajapakse, Chamith S., Chen, Cheng, Saha, Punam K., Honig, Stephen, Chang, Gregory

“…Background A current challenge in osteoporosis is identifying patients at risk of bone fracture. Purpose To identify the machine learning classifiers that…”
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A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects by Choquet, Hélène, Melles, Ronald B., Anand, Deepti, Yin, Jie, Cuellar-Partida, Gabriel, Wang, Wei, Hoffmann, Thomas J., Nair, K. Saidas, Hysi, Pirro G., Lachke, Salil A., Jorgenson, Eric

“…Cataract is the leading cause of blindness among the elderly worldwide and cataract surgery is one of the most common operations performed in the United…”
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Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci by Bell, Christopher G., Gao, Fei, Yuan, Wei, Roos, Leonie, Acton, Richard J., Xia, Yudong, Bell, Jordana, Ward, Kirsten, Mangino, Massimo, Hysi, Pirro G., Wang, Jun, Spector, Timothy D.

“…Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the…”
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Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma: A 2-Sample Mendelian Randomization Study by Choquet, Hélène, Khawaja, Anthony P, Jiang, Chen, Yin, Jie, Melles, Ronald B, Glymour, M Maria, Hysi, Pirro G, Jorgenson, Eric

“…Refractive error (RE) is the most common form of visual impairment, and myopic RE is associated with an increased risk of primary open-angle glaucoma (POAG)…”
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Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases by Simcoe, Mark J, Khawaja, Anthony P, Hysi, Pirro G, Hammond, Christopher J

“…Abstract Corneal hysteresis and corneal resistance factor are parameters that reflect the dynamic biomechanical properties of the cornea and have been shown to…”
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Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia by Clark, Rosie, Pozarickij, Alfred, Hysi, Pirro G, Ohno-Matsui, Kyoko, Williams, Cathy, Guggenheim, Jeremy A

“…Myopia most often develops during school age, with the highest incidence in countries with intensive education systems. Interactions between genetic variants…”
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Population screening for glaucoma in UK: current recommendations and future directions by Hamid, Sana, Desai, Parul, Hysi, Pirro, Burr, Jennifer M., Khawaja, Anthony P.

“…Effective population screening for glaucoma would enable earlier diagnosis and prevention of irreversible vision loss. The UK National Screening Committee…”
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Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure by Visconti, Alessia, Duffy, David L., Liu, Fan, Zhu, Gu, Wu, Wenting, Chen, Yan, Hysi, Pirro G., Zeng, Changqing, Sanna, Marianna, Iles, Mark M., Kanetsky, Peter A., Demenais, Florence, Hamer, Merel A., Uitterlinden, Andre G., Ikram, M. Arfan, Nijsten, Tamar, Martin, Nicholas G., Kayser, Manfred, Spector, Tim D., Han, Jiali, Bataille, Veronique, Falchi, Mario

“…The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin…”
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One-year surgical outcomes of the PreserFlo MicroShunt in glaucoma: a multicentre analysis by Tanner, Alexander, Haddad, Fadi, Fajardo-Sanchez, Julia, Nguyen, Ethan, Thong, Kai Xin, Ah-Moye, Sarah, Perl, Nicole, Abu-Bakra, Mohammed, Kulkarni, Avinash, Trikha, Sameer, Lascaratos, Gerassimos, Parnell, Miles, Kailani, Obeda, King, Anthony J, Agrawal, Pavi, Stead, Richard, Giannouladis, Konstantinos, Rodrigues, Ian, Goyal, Saurabh, Hysi, Pirro G, Lim, Sheng, Yu-Wai-Man, Cynthia

“…To evaluate the efficacy and safety of the PreserFlo MicroShunt glaucoma device in a multicentre cohort study. All consecutive patients who received the…”
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