Search Results - "HYMAN, Anthony"

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing by Alberti, Simon, Hyman, Anthony A.

“…Biomolecular condensates are membraneless intracellular assemblies that often form via liquid−liquid phase separation and have the ability to concentrate…”
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Are aberrant phase transitions a driver of cellular aging? by Alberti, Simon, Hyman, Anthony A.

“…Why do cells age? Recent advances show that the cytoplasm is organized into many membrane‐less compartments via a process known as phase separation, which…”
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Liquid-Liquid Phase Separation in Biology by Hyman, Anthony A, Weber, Christoph A, Jülicher, Frank

“…Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that…”
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RNA buffers the phase separation behavior of prion-like RNA binding proteins by Maharana, Shovamayee, Wang, Jie, Papadopoulos, Dimitrios K, Richter, Doris, Pozniakovsky, Andrey, Poser, Ina, Bickle, Marc, Rizk, Sandra, Guillén-Boixet, Jordina, Franzmann, Titus M, Jahnel, Marcus, Marrone, Lara, Chang, Young-Tae, Sterneckert, Jared, Tomancak, Pavel, Hyman, Anthony A, Alberti, Simon

“…Prion-like RNA binding proteins (RBPs) such as TDP43 and FUS are largely soluble in the nucleus but form solid pathological aggregates when mislocalized to the…”
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ATP as a biological hydrotrope by Patel, Avinash, Malinovska, Liliana, Saha, Shambaditya, Wang, Jie, Alberti, Simon, Krishnan, Yamuna, Hyman, Anthony A.

“…Hydrotropes are small molecules that solubilize hydrophobic molecules in aqueous solutions. Typically, hydrotropes are amphiphilic molecules and differ from…”
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Biomolecular condensates: organizers of cellular biochemistry by Banani, Salman F., Lee, Hyun O., Hyman, Anthony A., Rosen, Michael K.

“…Key Points In addition to canonical membrane-bound organelles, eukaryotic cells contain numerous membraneless compartments, or biomolecular condensates, that…”
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A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances by Hein, Marco Y., Hubner, Nina C., Poser, Ina, Cox, Jürgen, Nagaraj, Nagarjuna, Toyoda, Yusuke, Gak, Igor A., Weisswange, Ina, Mansfeld, Jörg, Buchholz, Frank, Hyman, Anthony A., Mann, Matthias

“…The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the…”
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Organelle Growth Control through Limiting Pools of Cytoplasmic Components by Goehring, Nathan W., Hyman, Anthony A.

“…The critical importance of controlling the size and number of intracellular organelles has led to a variety of mechanisms for regulating the formation and…”
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Controlling compartmentalization by non-membrane-bound organelles by Wheeler, Richard J., Hyman, Anthony A.

“…Compartmentalization is a characterizing feature of complexity in cells, used to organize their biochemistry. Membrane-bound organelles are most widely known,…”
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Beyond Oil and Water—Phase Transitions in Cells by Hyman, Anthony A., Simons, Kai

“…The organization of cellular compartments may be driven by liquid phase separations and the collective low-affinity interactions of macromolecules…”
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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation by Patel, Avinash, Lee, Hyun O., Jawerth, Louise, Maharana, Shovamayee, Jahnel, Marcus, Hein, Marco Y., Stoynov, Stoyno, Mahamid, Julia, Saha, Shambaditya, Franzmann, Titus M., Pozniakovski, Andrej, Poser, Ina, Maghelli, Nicola, Royer, Loic A., Weigert, Martin, Myers, Eugene W., Grill, Stephan, Drechsel, David, Hyman, Anthony A., Alberti, Simon

“…Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study…”
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Growth and division of active droplets provides a model for protocells by Zwicker, David, Seyboldt, Rabea, Weber, Christoph A., Hyman, Anthony A., Jülicher, Frank

“…It has been proposed that during the early steps in the origin of life, small droplets could have formed via the segregation of molecules from complex mixtures…”
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Organization and Function of Non-dynamic Biomolecular Condensates by Woodruff, Jeffrey B., Hyman, Anthony A., Boke, Elvan

“…Cells compartmentalize biochemical reactions using organelles. Organelles can be either membrane-bound compartments or supramolecular assemblies of protein and…”
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Protein condensates as aging Maxwell fluids by Jawerth, Louise, Fischer-Friedrich, Elisabeth, Saha, Suropriya, Wang, Jie, Franzmann, Titus, Zhang, Xiaojie, Sachweh, Jenny, Ruer, Martine, Ijavi, Mahdiye, Saha, Shambaditya, Mahamid, Julia, Hyman, Anthony A, Jülicher, Frank

“…Protein condensates are complex fluids that can change their material properties with time. However, an appropriate rheological description of these fluids…”
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A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins by Wang, Jie, Choi, Jeong-Mo, Holehouse, Alex S., Lee, Hyun O., Zhang, Xiaojie, Jahnel, Marcus, Maharana, Shovamayee, Lemaitre, Régis, Pozniakovsky, Andrei, Drechsel, David, Poser, Ina, Pappu, Rohit V., Alberti, Simon, Hyman, Anthony A.

“…Proteins such as FUS phase separate to form liquid-like condensates that can harden into less dynamic structures. However, how these properties emerge from the…”
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A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility by Bassik, Michael C., Kampmann, Martin, Lebbink, Robert Jan, Wang, Shuyi, Hein, Marco Y., Poser, Ina, Weibezahn, Jimena, Horlbeck, Max A., Chen, Siyuan, Mann, Matthias, Hyman, Anthony A., LeProust, Emily M., McManus, Michael T., Weissman, Jonathan S.

“…Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the…”
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Phase separation of a yeast prion protein promotes cellular fitness by Franzmann, Titus M, Jahnel, Marcus, Pozniakovsky, Andrei, Mahamid, Julia, Holehouse, Alex S, Nüske, Elisabeth, Richter, Doris, Baumeister, Wolfgang, Grill, Stephan W, Pappu, Rohit V, Hyman, Anthony A, Alberti, Simon

“…Despite the important role of prion domains in neurodegenerative disease, their physiological function has remained enigmatic. Previous work with yeast prions…”
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ASCB Keith Porter Lecture by Hyman, Anthony A

“…Although we attempt to plan the way we live, perhaps the best description of life is from the words of Yogi Berra: "It's tough to make predictions, especially…”
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Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles by Zwicker, David, Decker, Markus, Jaensch, Steffen, Hyman, Anthony A, Jülicher, Frank

“…Centrosomes are highly dynamic, spherical organelles without a membrane. Their physical nature and their assembly are not understood. Using the concept of…”
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Pericentriolar material structure and dynamics by Woodruff, Jeffrey B., Wueseke, Oliver, Hyman, Anthony A.

“…A centrosome consists of two barrel-shaped centrioles embedded in a matrix of proteins known as the pericentriolar material (PCM). The PCM serves as a platform…”
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