Search Results - "HVID, HENNING"

Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics by Moreno, Jaime, Gluud, Lise Lotte, Galsgaard, Elisabeth D, Hvid, Henning, Mazzoni, Gianluca, Das, Vivek

“…Chronic Kidney Disease (CKD) and Metabolic dysfunction-associated steatohepatitis (MASH) are metabolic fibroinflammatory diseases. Combining single-cell…”
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Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo by Hvid, Henning, Glendorf, Tine, Brandt, Jakob, Slaaby, Rita, Lützen, Anne, Kristensen, Kim, Hansen, Bo F.

“…Insulin analogue X10 has a higher mitogenic potency than native human insulin in vitro and supra-pharmacological doses of insulin X10 increased the incidence…”
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Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats by Jensen, Victoria Svop, Hvid, Henning, Damgaard, Jesper, Nygaard, Helle, Ingvorsen, Camilla, Wulff, Erik Max, Lykkesfeldt, Jens, Fledelius, Christian

“…In humans and animal models, excessive intake of dietary fat, fructose and cholesterol has been linked to the development of non-alcoholic fatty liver disease…”
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Temporal Development of Dyslipidemia and Nonalcoholic Fatty Liver Disease (NAFLD) in Syrian Hamsters Fed a High-Fat, High-Fructose, High-Cholesterol Diet by Svop Jensen, Victoria, Fledelius, Christian, Max Wulff, Erik, Lykkesfeldt, Jens, Hvid, Henning

“…The use of translationally relevant animal models is essential, also within the field of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic…”
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A systematic evaluation of state-of-the-art deconvolution methods in spatial transcriptomics: insights from cardiovascular disease and chronic kidney disease by Slabowska, Alban Obel, Pyke, Charles, Hvid, Henning, Jessen, Leon Eyrich, Baumgart, Simon, Das, Vivek

“…A major challenge in sequencing-based spatial transcriptomics (ST) is resolution limitations. Tissue sections are divided into hundreds of thousands of spots,…”
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Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD by Jensen, Victoria Svop, Fledelius, Christian, Zachodnik, Christina, Damgaard, Jesper, Nygaard, Helle, Tornqvist, Kristina Steinicke, Kirk, Rikke Kaae, Viuff, Birgitte Martine, Wulff, Erik Max, Lykkesfeldt, Jens, Hvid, Henning

“…Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent comorbidities in patients with Type 2 diabetes. While…”
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Treatment with insulin analog X10 and IGF-1 increases growth of colon cancer allografts by Hvid, Henning, Blouin, Marie-José, Birman, Elena, Damgaard, Jesper, Poulsen, Fritz, Fels, Johannes Josef, Fledelius, Christian, Hansen, Bo Falck, Pollak, Michael

“…Obesity and type 2 diabetes are associated with an increased risk for development of certain forms of cancer, including colon cancer. The publication of highly…”
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The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation by Cirera, Susanna, Taşöz, Emirhan, Juul Jacobsen, Mette, Schumacher-Petersen, Camilla, Østergaard Christoffersen, Berit, Kaae Kirk, Rikke, Pagh Ludvigsen, Trine, Hvid, Henning, Duelund Pedersen, Henrik, Høier Olsen, Lisbeth, Fredholm, Merete

“…Background Model animals are valuable resources for dissecting basic aspects of the regulation of obesity and metabolism. The translatability of results relies…”
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Diabetic Phenotype in the Small Intestine of Zucker Diabetic Fatty Rats by Hvid, Henning, Jensen, Stina Rikke, Witgen, Brent M, Fledelius, Christian, Damgaard, Jesper, Pyke, Charles, Rasmussen, Thomas Bovbjerg

“…In contrast to streptozotocin (STZ)-induced rodent models of diabetes, there are no thorough characterizations of the intestinal phenotype and the underlying…”
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Semaglutide treatment attenuates vessel remodelling in ApoE−/− mice following vascular injury and blood flow perturbation by Jensen, Ditte Marie, Skovsted, Gry Freja, Bonde, Mathilde Frederikke Bjørn, Bentzon, Jacob Fog, Rolin, Bidda, Franck, Grégory, Ougaard, Maria Katarina Elm, Voetmann, Louise Marie, Bachmann, Julian Christoffer, Uryga, Anna, Pyke, Charles, Kirk, Rikke Kaae, Hvid, Henning, Knudsen, Lotte Bjerre, Lykkesfeldt, Jens, Nyberg, Michael

“…Randomized clinical studies have shown a reduction in cardiovascular outcomes with glucagon-like peptide 1 receptor agonist (GLP-1RA) treatment with the…”
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TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis by Hvid, Henning, Teige, Ingrid, Kvist, Peter Helding, Svensson, Lars, Kemp, Kåre

“…Psoriasis is a common chronic inflammatory skin disease, characterized by epidermal hyperplasia, immune cell infiltration, increased dermal angiogenesis and…”
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Mammary gland proliferation in female rats: Effects of the estrous cycle, pseudo-pregnancy and age by Hvid, Henning, Thorup, Inger, Sjögren, Ingrid, Oleksiewicz, Martin B., Jensen, Henrik E.

“…Assessment of mammary gland proliferation in rats is an important endpoint in preclinical safety studies of pharmaceutical compounds. However, existing data on…”
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TPA induction leads to a T[sub]h17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis by Hvid, Henning, Teige, Ingrid, Peter Helding Kvist, Svensson, Lars, Kemp, Kåre

“…Psoriasis is a common chronic inflammatory skin disease, characterized by epidermal hyperplasia, immune cell infiltration, increased dermal angiogenesis and…”
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THU-248 Unraveling the interplay of FGF21 and GLP1 analogue in metabolic dysfunction-associated steatohepatitis in vivo by Oldenburger, Anouk, Björkenberg, Birgitte, Hvid, Henning, Gillum, Matthew, Pfister, Dominik, Veidal, Sanne Skovgård, Andersen, Birgitte

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Kidney Disease Progression in Obese ZSF1 Rats Treated with the SGLT2 Inhibitor Empagliflozin: FR-PO357 by Hummelgaard, Sandra, Kirchhoff, Jeppe, Hvid, Henning, Glerup, Simon, Birn, Henrik, Weyer, Kathrin

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802-P: Beneficial Effects of a Functionally Selective Insulin on Vascular Function and Liver Triglycerides by OLSEN, GRITH S., PEDERSEN, THOMAS A., SLAABY, RITA, HANSEN, BO F., GLENDORF, TINE, DEMOZAY, DAMIEN, HVID, HENNING, NISHIMURA, ERICA, BRANDT, JAKOB, POVLEN, GRO

“…Selective insulin resistance, where insulin's ability to lower blood glucose via the Akt signaling pathway gradually decreases while retaining its…”
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WED-411 - Biomarkers identifying hepatic inflammation in non-alcoholic fatty liver disease (NAFLD) by Werge, Mikkel, Hoegl, Annabelle, Therkelsen, Marie Louise, Grønborg, Mads, Mazzoni, Gianluca, Harder, Lea Mørch, Hvid, Henning, Rashu, Elias, Thing, Mira, Hetland, Liv, Junker, Anders, Serizawa, Reza, Vyberg, Mogens, Galsgaard, Elisabeth, Gluud, Lise Lotte

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Biomarkers identifying hepatic inflammation in non-alcoholic fatty liver disease (NAFLD) by Werge, Mikkel, Hoegl, Annabelle, Therkelsen, Marie Louise, Grønborg, Mads, Mazzoni, Gianluca, Harder, Lea Mørch, Hvid, Henning, Rashu, Elias, Thing, Mira, Hetland, Liv, Junker, Anders, Serizawa, Reza, Vyberg, Mogens, Galsgaard, Elisabeth, Gluud, Lise Lotte

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Quantitative Assessment of Epithelial Proliferation in Rat Mammary Gland Using Artificial Intelligence Independent of Choice of Proliferation Marker by Dovmark, Tobias H., Kvist, Peter H., Mølck, Anne-Marie, Hvid, Henning

“…Epithelial proliferation in the rat mammary gland is recommended in regulatory guidelines as an endpoint for assessment of the in vivo carcinogenic potential…”
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WED-421 - Growth differentiation factor 15 in plasma and liver is associated with hepatic oxidative stress in non-alcoholic fatty liver disease by Werge, Mikkel, Grandt, Josephine, Thing, Mira, Hetland, Liv, Rashu, Elias, Jensen, Anne-Sofie Houlberg, Junker, Anders, Richter, Martin, Møller, Søren, Bendtsen, Flemming, Harder, Lea Mørch, Mazzoni, Gianluca, Viuff, Birgitte, Hvid, Henning, Jørgensen, Sebastian, Bendtsen, Kristian, Kildegaard, Jonas, Vyberg, Mogens, Serizawa, Reza, Galsgaard, Elisabeth, Wewer Albrechtsen, Nicolai J, Gluud, Lise Lotte

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