Search Results - "HUYSMANS, H"

Millisecond dynamics of an unlabeled amino acid transporter by Matin, Tina R., Heath, George R., Huysmans, Gerard H. M., Boudker, Olga, Scheuring, Simon

“…Excitatory amino acid transporters (EAATs) are important in many physiological processes and crucial for the removal of excitatory amino acids from the…”
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Ketamine: differential neurophysiological dynamics in functional networks in the rat brain by Ahnaou, A, Huysmans, H, Biermans, R, Manyakov, N V, Drinkenburg, W H I M

“…Recently, the N -methyl- d -aspartate-receptor (NMDAR) antagonist ketamine has emerged as a fast-onset mechanism to achieve antidepressant activity, whereas…”
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Cortical high gamma network oscillations and connectivity: a translational index for antipsychotics to normalize aberrant neurophysiological activity by Ahnaou, A., Huysmans, H., Van de Casteele, T., Drinkenburg, W. H. I. M.

“…Oscillatory activity in the gamma frequency range is a critical mechanism, which integrates neural networks within and across brain structures during cognitive…”
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Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential by Ahnaou, A., Huysmans, H., Jacobs, T., Drinkenburg, W.H.I.M.

“…Synchronization of electroencephalographic (EEG) oscillations represents a core mechanism for cortical and subcortical networks, and disturbance in neural…”
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Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog by Huang, Yun, Wang, Xiaoyu, Lv, Guohua, Razavi, Asghar M., Huysmans, Gerard H. M., Weinstein, Harel, Bracken, Clay, Eliezer, David, Boudker, Olga

“…In proteins where conformational changes are functionally important, the number of accessible states and their dynamics are often difficult to establish. Here…”
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Bacterial Secretins Form Constitutively Open Pores Akin to General Porins by Disconzi, Elena, Guilvout, Ingrid, Chami, Mohamed, Masi, Muriel, Huysmans, Gerard H. M, Pugsley, Anthony P, Bayan, Nicolas

“…Proteins called secretins form large multimeric complexes that are essential for macromolecular transit across the outer membrane of Gram-negative bacteria…”
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transition state for folding of an outer membrane protein by Huysmans, Gerard H.M, Baldwin, Stephen A, Brockwell, David J, Radford, Sheena E

“…Inspired by the seminal work of Anfinsen, investigations of the folding of small water-soluble proteins have culminated in detailed insights into how these…”
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The phosphodiesterase-4 and glycine transporter-1 inhibitors enhance in vivo hippocampal theta network connectivity and synaptic plasticity, whereas D-serine does not by Ahnaou, A., Broadbelt, T., Biermans, R., Huysmans, H., Manyakov, N. V., Drinkenburg, W. H. I. M.

“…Dysfunctional N-methyl-D-aspartate receptors (NMDARs) and cyclic adenosine monophosphate (cAMP) have been associated with deficits in synaptic plasticity and…”
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Molecular basis for the folding of β-helical autotransporter passenger domains by Yuan, Xiaojun, Johnson, Matthew D., Zhang, Jing, Lo, Alvin W., Schembri, Mark A., Wijeyewickrema, Lakshmi C., Pike, Robert N., Huysmans, Gerard H. M., Henderson, Ian R., Leyton, Denisse L.

“…Bacterial autotransporters comprise a C-terminal β-barrel domain, which must be correctly folded and inserted into the outer membrane to facilitate…”
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Off-target potential of AMN082 on sleep EEG and related physiological variables: Evidence from mGluR7 (−/−) mice by Ahnaou, A., Raeyemaekers, L., Huysmans, H., Drinkenburg, W.H.I.M.

“…•AMN082 is widely used to explore the functional role of mGluR7.•AMN082 increased state transitions towards wakefulness and reduced slow wave activity during…”
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Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men by Ahnaou, A., de Boer, P., Lavreysen, H., Huysmans, H., Sinha, V., Raeymaekers, L., Van De Casteele, T., Cid, J.M., Van Nueten, L., Macdonald, G.J., Kemp, J.A., Drinkenburg, W.H.I.M.

“…Alterations in rapid eye movement sleep (REM) have been suggested as valid translational efficacy markers: activation of the metabotropic glutamate receptor 2…”
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Contribution of melanin-concentrating hormone (MCH1) receptor to thermoregulation and sleep stabilization: Evidence from MCH1 (−/−) mice by Ahnaou, A., Dautzenberg, F.M., Huysmans, H., Steckler, T., Drinkenburg, W.H.I.M.

“…▶ MCH1r (−/−) mice exhibited increases body temperature and reduced NREM sleep time. ▶ Reduced NREM sleep by shorter NREM sleep episodes may impact sleep…”
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Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery : A randomized clinical trial by VAN DE WATERING, L. M. G, HERMANS, J, HOUBIERS, J. G. A, VAN DEN BROEK, P. J, BOUTER, H, BOER, F, HARVEY, M. S, HUYSMANS, H. A, BRAND, A

“…Leukocytes in transfused blood are associated with several posttransfusion immunomodulatory effects. Although leukocytes play an important role in reperfusion…”
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Independent Domain Assembly in a Trapped Folding Intermediate of Multimeric Outer Membrane Secretins by Guilvout, Ingrid, Chami, Mohamed, Disconzi, Elena, Bayan, Nicolas, Pugsley, Anthony P., Huysmans, Gerard H.M.

“…The outer membrane portal of the Klebsiella oxytoca type II secretion system, PulD, is a prototype of a family of proteins, the secretins, which are essential…”
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The high‐energy transition state of the glutamate transporter homologue GltPh by Huysmans, Gerard H M, Ciftci, Didar, Wang, Xiaoyu, Blanchard, Scott C, Boudker, Olga

“…Membrane transporters mediate cellular uptake of nutrients, signaling molecules, and drugs. Their overall mechanisms are often well understood, but the…”
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A urea channel from Bacillus cereus reveals a novel hexameric structure by Huysmans, Gerard H M, Chan, Nathan, Baldwin, Jocelyn M, Postis, Vincent L G, Tzokov, Svetomir B, Deacon, Sarah E, Yao, Sylvia Y M, Young, James D, McPherson, Michael J, Bullough, Per A, Baldwin, Stephen A

“…Urea is exploited as a nitrogen source by bacteria, and its breakdown products, ammonia and bicarbonate, are employed to counteract stomach acidity in…”
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Linking function to global and local dynamics in an elevator-type transporter by Ciftci, Didar, Martens, Chloe, Ghani, Vishnu G., Blanchard, Scott C., Politis, Argyris, Huysmans, Gerard H. M., Boudker, Olga

“…Transporters cycle through large structural changes to translocate molecules across biological membranes. The temporal relationships between these changes and…”
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Brom’s three-patch technique for repair of supravalvular aortic stenosis by Hazekamp, Mark G., Kappetein, Arie-Pieter, Schoof, Paul H., Ottenkamp, Jaap, Witsenburg, Maarten, Huysmans, Hans A., Bogers, Ad J.J.C.

“…Objective: Case histories of all patients (n = 29) operated on for supravalvular aortic stenosis from 1962 to the present were reviewed to study different…”
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Folding outer membrane proteins independently of the β-barrel assembly machinery: an assembly pathway for multimeric complexes? by Huysmans, Gerard H M

“…Since the discovery of the essential role of the β-barrel assembly machinery (BAM) for the membrane insertion of outer membrane proteins (OMPs) that are…”
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Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD by Guilvout, Ingrid, Brier, Sébastien, Chami, Mohamed, Hourdel, Véronique, Francetic, Olivera, Pugsley, Anthony P., Chamot-Rooke, Julia, Huysmans, Gerard H.M.

“…Members of a group of multimeric secretion pores that assemble independently of any known membrane-embedded insertase in Gram-negative bacteria fold into a…”
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