Search Results - "HUTTARY, Nicole"

A systems pharmacology workflow with experimental validation to assess the potential of anakinra for treatment of focal and segmental glomerulosclerosis by Boehm, Michael, Bukosza, Eva Nora, Huttary, Nicole, Herzog, Rebecca, Aufricht, Christoph, Kratochwill, Klaus, Gebeshuber, Christoph A

“…Focal and Segmental Glomerulosclerosis (FSGS) is a severe glomerulopathy that frequently leads to end stage renal disease. Only a subset of patients responds…”
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Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse by Kerjaschki, Dontscho, Bago-Horvath, Zsuzsanna, Rudas, Margaretha, Sexl, Veronika, Schneckenleithner, Christine, Wolbank, Susanne, Bartel, Gregor, Krieger, Sigurd, Kalt, Romana, Hantusch, Brigitte, Keller, Thomas, Nagy-Bojarszky, Katalin, Huttary, Nicole, Raab, Ingrid, Lackner, Karin, Krautgasser, Katharina, Schachner, Helga, Kaserer, Klaus, Rezar, Sandra, Madlener, Sybille, Vonach, Caroline, Davidovits, Agnes, Nosaka, Hitonari, Hämmerle, Monika, Viola, Katharina, Dolznig, Helmut, Schreiber, Martin, Nader, Alexander, Mikulits, Wolfgang, Gnant, Michael, Hirakawa, Satoshi, Detmar, Michael, Alitalo, Kari, Nijman, Sebastian, Offner, Felix, Maier, Thorsten J, Steinhilber, Dieter, Krupitza, Georg

“…In individuals with mammary carcinoma, the most relevant prognostic predictor of distant organ metastasis and clinical outcome is the status of axillary lymph…”
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Flavonoids Distinctly Stabilize Lymph Endothelial- or Blood Endothelial Disintegration Induced by Colon Cancer Spheroids SW620 by Berenda, Julia, Smöch, Claudia, Stadlbauer, Christa, Mittermair, Eva, Taxauer, Karin, Huttary, Nicole, Krupitza, Georg, Krenn, Liselotte

“…The health effects of plant phenolics in vegetables and other food and the increasing evidence of the preventive potential of flavonoids in "Western Diseases"…”
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ECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS by Bukosza, Eva Nora, Kornauth, Christoph, Hummel, Karin, Schachner, Helga, Huttary, Nicole, Krieger, Sigurd, Nöbauer, Katharina, Oszwald, André, Razzazi Fazeli, Ebrahim, Kratochwill, Klaus, Aufricht, Christoph, Szénási, Gabor, Hamar, Peter, Gebeshuber, Christoph A

“…The glomerular basement membrane (GBM) and extra-cellular matrix (ECM) are essential to maintain a functional interaction between the glomerular podocytes and…”
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Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro by Hong, Junli, Fristiohady, Adryan, Nguyen, Chi H, Milovanovic, Daniela, Huttary, Nicole, Krieger, Sigurd, Hong, Junqiang, Geleff, Silvana, Birner, Peter, Jäger, Walter, Özmen, Ali, Krenn, Liselotte, Krupitza, Georg

“…Flavonoids, present in fruits, vegetables and traditional medicinal plants, show anticancer effects in experimental systems and are reportedly non-toxic. This…”
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Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants by Kerjaschki, Dontscho, Huttary, Nicole, Raab, Ingrid, Regele, Heinz, Bojarski-Nagy, Katalin, Bartel, Gregor, Kröber, Stefan M, Greinix, Hildegard, Rosenmaier, Agathe, Karlhofer, Franz, Wick, Nikolaus, Mazal, Peter R

“…De novo lymphangiogenesis influences the course of different human diseases as diverse as chronic renal transplant rejection and tumor metastasis. The cellular…”
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Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro by Holzner, Silvio, Senfter, Daniel, Stadler, Serena, Staribacher, Anna, Nguyen, Chi Huu, Gaggl, Anna, Geleff, Silvana, Huttary, Nicole, Krieger, Sigurd, Jäger, Walter, Dolznig, Helmut, Mader, Robert M, Krupitza, Georg

“…Since cancer cells, when grown as spheroids, display drug sensitivity and radiation resistance patterns such as seen in vivo we recently established a…”
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Reliable quantification of protein expression and cellular localization in histological sections by Schlederer, Michaela, Mueller, Kristina M, Haybaeck, Johannes, Heider, Susanne, Huttary, Nicole, Rosner, Margit, Hengstschläger, Markus, Moriggl, Richard, Dolznig, Helmut, Kenner, Lukas

“…In targeted therapy, patient tumors are analyzed for aberrant activations of core cancer pathways, monitored based on biomarker expression, to ensure efficient…”
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Alterations in Fatty Acid Utilization and an Impaired Antioxidant Defense Mechanism Are Early Events in Podocyte Injury by Mayrhofer, Corina, Krieger, Sigurd, Huttary, Nicole, Chang, Martina Wei-Fen, Grillari, Johannes, Allmaier, Günter, Kerjaschki, Dontscho

“…Ultrastructural alterations of podocytes are closely associated with loss of glomerular filtration function. In the present study, we explored changes at the…”
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Different mechanisms of saturated versus polyunsaturated FFA-induced apoptosis in human endothelial cells by Artwohl, Michaela, Lindenmair, Andrea, Sexl, Veronika, Maier, Christina, Rainer, Georg, Freudenthaler, Angelika, Huttary, Nicole, Wolzt, Michael, Nowotny, Peter, Luger, Anton, Baumgartner-Parzer, Sabina M.

“…Apoptosis and underlying mechanisms were evaluated in human umbilical vein endothelial cells (HUVECs), in target tissues of late diabetic vascular…”
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Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells by Artwohl, Michaela, Hölzenbein, Thomas, Fürnsinn, Clemens, Freudenthaler, Angelika, Huttary, Nicole, Waldhäusl, Werner Klaus, Baumgartner-Parzer, Sabina M

“…This study evaluated direct effects of peroxisome proliferatoractivated receptor gamma(PPARgamma) agonists, including thiazolidinediones (TZDs), on vascular…”
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Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching by Nguyen, Chi Huu, Stadler, Serena, Brenner, Stefan, Huttary, Nicole, Krieger, Sigurd, Jäger, Walter, Dolznig, Helmut, Krupitza, Georg

“…Background: The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC)…”
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Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro by Senfter, Daniel, Holzner, Silvio, Kalipciyan, Maria, Staribacher, Anna, Walzl, Angelika, Huttary, Nicole, Krieger, Sigurd, Brenner, Stefan, Jäger, Walter, Krupitza, Georg, Dolznig, Helmut, Mader, Robert M

“…Invasive colorectal cancer is associated with poor prognosis requiring treatment with systemic chemotherapies usually including 5-fluorouracil. A consequence…”
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Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling by Stadler, Serena, Nguyen, Chi Huu, Schachner, Helga, Milovanovic, Daniela, Holzner, Silvio, Brenner, Stefan, Eichsteininger, Julia, Stadler, Mira, Senfter, Daniel, Krenn, Liselotte, Schmidt, Wolfgang M., Huttary, Nicole, Krieger, Sigurd, Koperek, Oskar, Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Marian, Brigitte, de Wever, Oliver, Mader, Robert M., Giessrigl, Benedikt, Jäger, Walter, Dolznig, Helmut, Krupitza, Georg

“…Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances…”
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AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis by Nguyen, Chi Huu, Brenner, Stefan, Huttary, Nicole, Atanasov, Atanas Georgiev, Dirsch, Verena Maria, Chatuphonprasert, Waranya, Holzner, Sivio, Stadler, Serena, Riha, Juliane, Krieger, Sigurd, de Martin, Rainer, Bago-Horvath, Zsuzsanna, Krupitza, Georg, Jäger, Walter

“…A causal link between overexpression of aryl hydrocarbon receptor (AHR) and its target cytochrome P450 1A1 (CYP1A1) and metastatic outgrowth of various cancer…”
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12 by Krieger, Sigurd, de Martin, Rainer, Krupitza, Georg, Nguyen, Chi Huu, Jager, Walter, Basilio, Jose, Fristiohady, Adryan, Huttary, Nicole, Milovanovic, Daniela

“…Metastasising breast cancer cells communicate with adjacent lymph endothelia, intravasate and disseminate through lymphatic routes, colonise lymph nodes and…”
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12(S)-HETE induces lymph endothelial cell retraction in�vitro by upregulation of SOX18 by Fristiohady, Adryan, Milovanovic, Daniela, Krieger, Sigurd, Huttary, Nicole, Nguyen, Chi, Basilio, Jose, J�ger, Walter, De Martin, Rainer, Krupitza, Georg

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Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro by Holzner, Silvio, Brenner, Stefan, Atanasov, Atanas Georgiev, Senfter, Daniel, Stadler, Serena, Nguyen, Chi Huu, Fristiohady, Adryan, Milovanovic, Daniela, Huttary, Nicole, Krieger, Sigurd, Bago-Horvath, Zsuzsanna, de Wever, Oliver, Tentes, Ioannis, Özmen, Ali, Jäger, Walter, Dolznig, Helmut, Dirsch, Verena Maria, Mader, Robert Michael, Krenn, Liselotte, Krupitza, Georg

“…Mechanisms how colorectal cancer (CRC) cells penetrate blood micro-vessel endothelia and metastasise is poorly understood. To study blood endothelial cell…”
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Feed‑back loops integrating RELA, SOX18 and FAK mediate the break‑down of the lymph‑endothelial barrier that is triggered by 12(S)‑HETE by Engleitner, Stefanie, Milovanovic, Daniela, Kirisits, Kerstin, Brenner, Stefan, Hong, Junli, Ropek, Nathalie, Huttary, Nicole, Rehak, Judith, Nguyen, Chi Huu, Bago-Horvath, Zsuzsanna, Knasmüller, Siegfried, De Martin, Rainer, Jäger, Walter, Krupitza, Georg

“…Metastatic cancer cells cross endothelial barriers and travel through the blood or lymphatic fluid to pre‑metastatic niches, leading to their colonisation. 'S'…”
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NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro by Nguyen, Chi Huu, Senfter, Daniel, Basilio, Jose, Holzner, Silvio, Stadler, Serena, Krieger, Sigurd, Huttary, Nicole, Milovanovic, Daniela, Viola, Katharina, Simonitsch-Klupp, Ingrid, Jäger, Walter, de Martin, Rainer, Krupitza, Georg

“…RELA, RELB, CREL, NFKB1 and NFKB2, and the upstream regulators NEMO and NIK were knocked-down in lymph endothelial cells (LECs) and in MDA-MB231 breast cancer…”
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