Search Results - "HUTEAU, Valérie"

Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries by Randrianjatovo-Gbalou, Irina, Rosario, Sandrine, Sismeiro, Odile, Varet, Hugo, Legendre, Rachel, Coppée, Jean-Yves, Huteau, Valérie, Pochet, Sylvie, Delarue, Marc

“…Abstract Nucleic acid aptamers, especially RNA, exhibit valuable advantages compared to protein therapeutics in terms of size, affinity and specificity…”
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Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria by Clément, David A., Gelin, Muriel, Leseigneur, Clarisse, Huteau, Valérie, Mondange, Lou, Pons, Jean-Luc, Dussurget, Olivier, Lionne, Corinne, Labesse, Gilles, Pochet, Sylvie

“…Nicotinamide adenine dinucleotide kinases (NAD kinases) are essential and ubiquitous enzymes involved in the production of NADP(H) which is an essential…”
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New Chemical Probe Targeting Bacterial NAD Kinase by Clément, David A, Leseigneur, Clarisse, Gelin, Muriel, Coelho, Dylan, Huteau, Valérie, Lionne, Corinne, Labesse, Gilles, Dussurget, Olivier, Pochet, Sylvie

“…Nicotinamide adenine dinucleotide (NAD) kinases are essential and ubiquitous enzymes involved in the tight regulation of NAD/nicotinamide adenine dinucleotide…”
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Structure‐based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase by Rahimova, Rahila, Nogaret, Pauline, Huteau, Valérie, Gelin, Muriel, Clément, David A., Labesse, Gilles, Pochet, Sylvie, Blanc‐Potard, Anne‐Béatrice, Lionne, Corinne

“…Multidrug resistance is a major public health problem that requires the urgent development of new antibiotics and therefore the identification of novel…”
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Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction by Morellato, Laurence, Huteau, Valérie, Pochet, Sylvie

“…•We synthesize original N9-heteroarylpurines via copper-mediated C–N bond formation.•The substrate scope was extended to sterically demanding…”
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Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: Synthesis and in vitro anti-mycobacterial activity by Gasse, Cécile, Douguet, Dominique, Huteau, Valérie, Marchal, Gilles, Munier-Lehmann, Hélène, Pochet, Sylvie

“…A series of N 1-(4-substituted-benzyl)-pyrimidines as potential inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis were synthesized and…”
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8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode by Paoletti, Julie, Assairi, Liliane, Gelin, Muriel, Huteau, Valérie, Nahori, Marie-Anne, Dussurget, Olivier, Labesse, Gilles, Pochet, Sylvie

“…Increased resistance of pathogens to existing antibiotics necessitates the search for novel targets to develop potent antimicrobials. Biosynthetic pathways of…”
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A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates by LO-MAN, Richard, VICHIER-GUERRE, Sophie, PERRAUT, Ronald, DERIAUD, Edith, HUTEAU, Valérie, BENMOHAMED, Lbachir, DIOP, Ousmane M, LIVINGSTON, Philip O, BAY, Sylvie, LECLERC, Claude

“…We recently developed an efficient strategy based on a fully synthetic dendrimeric carbohydrate display (multiple antigenic glycopeptide; MAG) to induce…”
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A new synthetic access to furo[3,2- f]chromene analogues of an antimycobacterial by Alvey, Luke, Prado, Soizic, Huteau, Valérie, Saint-Joanis, Brigitte, Michel, Sylvie, Koch, Michel, Cole, Stewart T., Tillequin, François, Janin, Yves L.

“…From the structure of 3,3-dimethyl-3 H-benzofuro[3,2- f][1]-benzopyran, a selective in vitro inhibitor of mycobacterial growth, we have undertaken a…”
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Screening and In Situ Synthesis Using Crystals of a NAD Kinase Lead to a Potent Antistaphylococcal Compound by Gelin, Muriel, Poncet-Montange, Guillaume, Assairi, Liliane, Morellato, Laurence, Huteau, Valérie, Dugué, Laurence, Dussurget, Olivier, Pochet, Sylvie, Labesse, Gilles

“…Making new ligands for a given protein by in situ ligation of building blocks (or fragments) is an attractive method. However, it suffers from inherent…”
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From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus by Gelin, Muriel, Paoletti, Julie, Nahori, Marie-Anne, Huteau, Valérie, Leseigneur, Clarisse, Jouvion, Grégory, Dugué, Laurence, Clément, David, Pons, Jean-Luc, Assairi, Liliane, Pochet, Sylvie, Labesse, Gilles, Dussurget, Olivier

“…Antibiotic resistance is a worldwide threat due to the decreasing supply of new antimicrobials. Novel targets and innovative strategies are urgently needed to…”
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A SERS probe for adenyl residues available for intermolecular interactions. Part II-Reactive adenyl sites in highly diluted DNA by Grajcar, Lydie, Huteau, Valérie, Huynh-Dinh, Tam, Baron, Marie-Hélène

“…Surface‐enhanced Raman spectroscopy (SERS) with an (Ag)n+ substrate detects picomoles of adenyl residues (Ayl) in a mildly salted aqueous medium (10−2 M NaCl)…”
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Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen by Vichier-Guerre, Sophie, Lo-Man, Richard, Huteau, Valérie, Dériaud, Edith, Leclerc, Claude, Bay, Sylvie

“…The glycopeptide vaccine MAG:Tn(hSer)3-PV induces a strong antibody immune response (IgG), which recognizes native tumor-associated antigens at the surface of…”
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Phosphorylcholine−Carbohydrate− Protein Conjugates Efficiently Induce Hapten-Specific Antibodies Which Recognize Both Streptococcus p neumoniae and Neisseria m eningitidis:  A Potential Multitarget Vaccine against Respiratory Infections by Bay, Sylvie, Huteau, Valérie, Zarantonelli, Maria-Leticia, Pires, René, Ughetto-Monfrin, Joël, Taha, Muhamed-Kheir, England, Patrick, Lafaye, Pierre

“…Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria…”
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Phosphorylcholine−Carbohydrate− Protein Conjugates Efficiently Induce Hapten-Specific Antibodies Which Recognize Both Streptococcus pneumoniae and Neisseria meningitidis:  A Potential Multitarget Vaccine against Respiratory Infections by BAY, Sylvie, HUTEAU, Valérie, ZARANTONELLI, Maria-Leticia, PIRES, René, UGHETTO-MONFRIN, Joël, TAHA, Muhamed-Kheir, ENGLAND, Patrick, LAFAYE, Pierre

“…Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria…”
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A New Family of Inhibitors of Mycobacterium Tuberculosis Thymidine Monophosphate Kinase by Gasse, C., Huteau, V., Douguet, D., Munier-Lehmann, H., Pochet, S.

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Assessment of adenyl residue reactivity within model nucleic acids by surface enhanced Raman spectroscopy by Grajcar, Lydie, El Amri, Chahrazade, Ghomi, Mahmoud, Fermandjian, Serge, Huteau, Valerie, Mandel, Richard, Lecomte, Sophie, Baron, Marie-Hélène

“…We rank the reactivity of the adenyl residues (A) of model DNA and RNA molecules with electropositive subnano size [Ag] n+ sites as a function of nucleic acid…”
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