Search Results - "HUTCHISON, C. A. III"

Complete mutagenesis of the HIV-1 protease by Loeb, Daniel D, Swanstrom, Ronald, Everitt, Lorraine, Manchester, Marianne, Stamper, Susan E, Hutchison, Clyde A

“…Retroviruses encode a protease which needs to be active for the production of infectious virions. A disabling mutation in the protease results in the…”
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Cleavage of HIV-1 gag polyprotein synthesized in vitro: sequential cleavage by the viral protease by Erickson-Viitanen, S, Manfredi, J, Viitanen, P, Tribe, D E, Tritch, R, Hutchison, 3rd, C A, Loeb, D D, Swanstrom, R

“…The virally encoded protease of human immunodeficiency virus is responsible for the processing of the gag and gag-pol polyprotein precursors to their mature…”
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Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases by LOEB, D. D, HUTCHISON, C. A. III, EDGELL, M. H, FARMERIE, W. G, SWANSTROM, R

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Expression and Processing of the AIDS Virus Reverse Transcriptase in Escherichia coli by Farmerie, William G., Loeb, Daniel D., Casavant, N. Carol, Hutchison, Clyde A., Edgell, Marshall H., Swanstrom, Ronald

“…The ability to express the genes of pathogenic human viruses, such as the acquired immune deficiency syndrome (AIDS) virus (also called human immunodeficiency…”
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Generating a Synthetic Genome by Whole Genome Assembly: ϕX174 Bacteriophage from Synthetic Oligonucleotides by Smith, Hamilton O., Hutchison, Clyde A., Pfannkoch, Cynthia, Venter, J. Craig

“…We have improved upon the methodology and dramatically shortened the time required for accurate assembly of 5- to 6-kb segments of DNA from synthetic…”
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Conservation throughout mammalia and extensive protein-encoding capacity of the highly repeated DNA long interspersed sequence one by Burton, F H, Loeb, D D, Voliva, C F, Martin, S L, Edgell, M H, Hutchison, 3rd, C A

“…We report an investigation of the structure, evolutionary history, and function of the highly repeated DNA family named Long Interspersed Sequence One (L1)…”
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The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end by Voliva, Charles F., Jahn, Carolyn L., Comer, Mary B., Hutchison, Clyde A., Edgell, Marshall H.

“…We have characterized a large repetitive element which has been found at seven different locations within the beta globin locus of the BALB/c mouse. This…”
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The F-type 5' motif of mouse L1 elements: a major class of L1 termini similar to the A-type in organization but unrelated in sequence by PADGETT, R. W, HUTCHISON, C. A. III, EDGELL, M. H

“…It has previously been shown that the L1 family in the mouse (L1Md) contains two alternative 5' ends called the A- and F-type sequences (1,2). We show here…”
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Sequence gel reading with a portable computer by HUTCHISON, C. A. III

“…DNA sequence data is traditionally transcribed onto paper, then typed into a computer for further analysis. This is a tedious, error prone process, which is…”
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Random oligonucleotide mutagenesis: application to a large protein coding sequence of a major histocompatibility complex class I gene, H-2DP by MURRAY, R, PEDERSON, K, PROSSER, H, MULLER, D, HUTCHISON, C. A. III, FRELINGER, J. A

“…We have used random oligonucleotide mutagenesis (or saturation mutagenesis) to create a library of point mutations in the alpha 1 protein domain of a Major…”
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diagonal-traverse homology search algorithm for locating similarities between two sequences by White, C.T, Hardies, S.C, Hutchison, C.A. III, Edgell, M.H

“…We present a fast computer algorithm for finding homology between two DNA sequences. It generates a two-dimensional display in which a diagonal string of dots…”
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Construction and properties of a ribosome-binding site mutation in gene E of phi X174 bacteriophage by GILLAM, S, ASTELL, C. R, JAHNKE, P, HUTCHISON, C. A. III, SMITH, M

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Gene Content Phylogeny of Herpesviruses by Montague, Michael G., Hutchison, Clyde A.

“…Clusters of orthologous groups [COGs; Tatusov, R. L., Koonin, E. V. & Lipman, D. J. (1997) Science 278, 631-637] were identified for a set of 13 completely…”
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Master genes in mammalian repetitive DNA amplification by Deininger, P L, Batzer, M A, Hutchison, 3rd, C A, Edgell, M H

“…The analysis of species-specific subfamilies of both the LINE and SINE mammalian repetitive DNA families suggests that such subfamilies have arisen by…”
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The sequence of a large L1Md element reveals a tandemly repeated 5' end and several features found in retrotransposons by LOEB, D. D, PADGETT, R. W, HARDIES, S. C, SHEHEE, W. R, COMER, M. B, EDGELL, M. H, HUTCHISON, C. A. III

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Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169 by Chee, M S, Bankier, A T, Beck, S, Bohni, R, Brown, C M, Cerny, R, Horsnell, T, Hutchison, 3rd, C A, Kouzarides, T, Martignetti, J A

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Control of methylation spreading in synthetic DNA sequences by the murine DNA methyltransferase by Tollefsbol, Trygve O, Hutchison, Clyde A

“…Methylation spreading, which involves a propensity for the mammalian DNA-(cytosine-5)-methyltransferase to de novo methylate cytosine-guanine dinucleotides…”
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Sequence Requirements of the HIV-1 Protease Flap Region Determined by Saturation Mutagenesis and Kinetic Analysis of Flap Mutants by Shao, Wei, Everitt, Lorraine, Manchester, Marianne, Loeb, Daniel D., Hutchison, Clyde A., Swanstrom, Ronald

“…The retroviral proteases (PRs) have a structural feature called the flap, which consists of a short antiparallel β -sheet with a turn. The flap extends over…”
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Characterization of Repetitive DNA in the Mycoplasma genitalium Genome: Possible Role in the Generation of Antigenic Variation by Peterson, Scott N., Bailey, Camella C., Jensen, Jorgen S., Borre, Martin B., King, Elizabeth S., Bott, Kenneth F., Hutchison, Clyde A.

“…We have characterized a family of repetitive DNA elements with homology to the MgPa cellular adhesion operon of Mycoplasma genitalium, a bacterium that has the…”
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The evolution of modern lineages of mouse L1 elements by Mears, M L, Hutchison, 3rd, C A

“…There are three known families of L1 elements in the Mus genome, V, F, and A. An individual L1 element is classified as a member of one of these families based…”
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