Search Results - "HUTCHINGS, AMANDA"

Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain by Corcos, Daniel, Osborn, Michael J., Matheson, Louise S., Santos, Fatima, Zou, Xiangang, Smith, Jennifer A., Morgan, Geoff, Hutchings, Amanda, Hamon, Maureen, Oxley, David, Brüggemann, Marianne

“…Russell bodies (RBs) are intracellular inclusions filled with protein aggregates. In diverse lymphoid disorders these occur as immunoglobulin (Ig) deposits,…”
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A Natural Hypomorphic Variant of the Apoptosis Regulator Gimap4/IAN1 by Carter, Christine, Dion, Carine, Schnell, Silke, Coadwell, W. John, Graham, Margaret, Hepburn, Lucy, Morgan, Geoffrey, Hutchings, Amanda, Pascall, John C, Jacobs, Heinz, Miller, J. Ross, Butcher, Geoffrey W

“…The Gimap/IAN family of GTPases has been implicated in the regulation of cell survival, particularly in lymphomyeloid cells. Prosurvival and prodeath…”
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Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria by Saunders, Amy, Lamb, Tracey, Pascall, John, Hutchings, Amanda, Dion, Carine, Carter, Christine, Hepburn, Lucy, Langhorne, Jean, Butcher, Geoffrey W

“…GIMAP (GTPase of the immunity-associated protein family) proteins are a family of putative GTPases believed to be regulators of cell death in lymphomyeloid…”
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The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein by Wong, Vivian W.Y., Saunders, Amy E., Hutchings, Amanda, Pascall, John C., Carter, Christine, Bright, Nicholas A., Walker, Simon A., Ktistakis, Nicholas T., Butcher, Geoffrey W.

“…A mutation in the rat GIMAP5 gene predisposes for autoimmunity, most famously in the BB rat model of autoimmune type 1 diabetes mellitus. This mutation is…”
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Post-testicular development of a novel membrane substructure within the equatorial segment of ram, bull, boar, and goat spermatozoa as viewed by atomic force microscopy by Ellis, Darren J, Shadan, Sadaf, James, Peter S, Henderson, Robert M, Michael Edwardson, J, Hutchings, Amanda, Jones, Roy

“…Atomic force microscopy has been used to investigate changes in the plasma membrane overlying the head region of mammalian spermatozoa (bull, boar, ram, goat,…”
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Selective Requirement for Cdc25C Protein Synthesis During Meiotic Progression in Porcine Oocytes by Dai, Yanfeng, Lee, Caroline, Hutchings, Amanda, Sun, Yunming, Moor, Robert

“…Fundamental differences between meiosis and mitosis suggest that the shared central cell cycle machinery may be regulated differently during the two division…”
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Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes by Saunders, Amy, Webb, Louise M.C., Janas, Michelle L., Hutchings, Amanda, Pascall, John, Carter, Christine, Pugh, Nicholas, Morgan, Geoff, Turner, Martin, Butcher, Geoffrey W.

“…The guanosine triphosphatases (GTPases) of the immunity-associated protein (GIMAP) family of putative GTPases has been implicated in the regulation of…”
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Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice by Zou, Xiangang, Osborn, Michael J, Bolland, Daniel J, Smith, Jennifer A, Corcos, Daniel, Hamon, Maureen, Oxley, David, Hutchings, Amanda, Morgan, Geoff, Santos, Fatima, Kilshaw, Peter J, Taussig, Michael J, Corcoran, Anne E, Brüggemann, Marianne

“…In healthy mammals, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is prevented by chaperone association of the H…”
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Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect by Qiu, Feng, Lakey, Anne, Agianian, Bogos, Hutchings, Amanda, Butcher, Geoffrey W, Labeit, Siegfried, Leonard, Kevin, Bullard, Belinda

“…The indirect flight muscles (IFMs) of Lethocerus (giant water bug) and Drosophila (fruitfly) are asynchronous: oscillatory contractions are produced by…”
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Prostacyclin release stimulated by thrombin or bradykinin in porcine endothelial cells cultured from aorta and umbilical vein by Pearson, J D, Carleton, J S, Hutchings, A

“…We have investigated the responsiveness of porcine endothelial cells, cultured from aorta or umbilical vein, to bradykinin and thrombin. Aortic cells studied…”
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Granulocyte migration through endothelium in culture by Beesley, J.E, Pearson, J.D, Hutchings, A, Carleton, J.S, Gordon, J.L

“…Using a model system with which we have previously investigated the adhesion of granulocytes to cultured endothelium, we have now shown that adherent…”
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Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes by Doody, G M, Billadeau, D D, Clayton, E, Hutchings, A, Berland, R, McAdam, S, Leibson, P J, Turner, M

“…We show here that Vav-2 is tyrosine phosphorylated following antigen receptor engagement in both B- and T-cells, but potentiates nuclear factor of activated T…”
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Cloning of three different species of MHC class I cDNAs of the RT1 g haplotype from the NEDH rat by Butcher, Geoffrey W., Joly, E., le Rolle, Anne-France, Hutchings, Amanda

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Vav-2 controls NFAT-dependent transcription inB- but not T-lymphocytes by Doody, Gina M., Billadeau, Daniel D., Clayton, Elizabeth, Hutchings, Amanda, Berland, Robert, McAdam, Simon, Leibson, Paul J., Turner, Martin

“…We show here that Vav‐2 is tyrosine phosphorylated following antigen receptor engagement in both B‐ and T‐cells, but potentiates nuclear factor of activated T…”
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Monoclonal antibodies to the major structural glycoprotein of the Chlamydomonas cell wall by Smith, Elizabeth, Roberts, Keith, Hutchings, Amanda, Galfre, Giovanni

“…A family of monoclonal antibodies (McAb) has been raised to the major cell-wall structural glycoprotein of the green alga Chlamydomonas reinhardii. The work…”
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intermediate filament-related system of higher plant cells shares an epitope with cytokeratin 8 by Ross, J.H.E, Hutchings, A, Butcher, G.W, Lane, E.B, Lloyd, C.W

“…It is now apparent that plants possess intermediate filament (IF) antigens that exist either as cytoplasmic fibrillar bundles (FBs) or in a finer form,…”
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Preparation and Characterization of Monoclonal Antibodies to a Butyrivibrio sp. and Their Potential Use in the Identification of Rumen Butyrivibrios, Using an Enzyme-linked Immunosorbent Assay by HAZLEWOOD, GEOFFREY P, THEODOROU, MICHAEL K, HUTCHINGS, AMANDA, JORDAN, DAVID J, GALFRE, GIOVANNI

“…1 Department of Biochemistry, AFRC Institute of Animal Physiology, Babraham Hall, Babraham, Cambridge CB2 4AT, UK 2 Monoclonal Antibody Centre, AFRC Institute…”
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Interaction of leukocytes with vascular cells in culture by Beesley, J.E, Pearson, J.D, Carleton, J.S, Hutchings, A, Gordon, J.L

“…The nature, kinetics and cofactor requirements of leukocyte adhesion to cultured vascular cells have been investigated in vitro, using a model system in which…”
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Granulocyte adhesion to endothelium in culture by Pearson, J D, Carleton, J S, Beesley, J E, Hutchings, A, Gordon, J L

“…We previously described a model system for studying the adherence of granulocytes to cultured endothelium, and have now investigated the effects of other blood…”
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