Search Results - "HUSSEIN, Bahira"

Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte by Trivedi, Purvi C., Bartlett, Jordan J., Mercer, Angella, Slade, Logan, Surette, Marc, Ballabio, Andrea, Flibotte, Stephane, Hussein, Bahira, Rodrigues, Brian, Kienesberger, Petra C., Pulinilkunnil, Thomas

“…Glucolipotoxicity following nutrient overload causes cardiomyocyte injury by inhibiting TFEB and suppressing lysosomal function. We ascertained whether in…”
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Flow-Induced Secretion of Endothelial Heparanase Regulates Cardiac Lipoprotein Lipase and Changes Following Diabetes by Lee, Chae Syng, Zhai, Yajie, Shang, Rui, Wong, Trevor, Mattison, Aurora J, Cen, Haoning Howard, Johnson, James D, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…Background Lipoprotein lipase (LPL)-derived fatty acid is a major source of energy for cardiac contraction. Synthesized in cardiomyocytes, LPL requires…”
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Diabetes Mellitus Severity and a Switch From Using Lipoprotein Lipase to Adipose-Derived Fatty Acid Results in a Cardiac Metabolic Signature That Embraces Cell Death by Puri, Karanjit, Lal, Nathaniel, Shang, Rui, Ghosh, Sanjoy, Flibotte, Stephane, Dyer, Roger, Hussein, Bahira, Rodrigues, Brian

“…Background Fatty acid (FA) provision to the heart is from cardiomyocyte and adipose depots, plus lipoprotein lipase action. We tested how a graded reduction in…”
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MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart by Nawaito, Sherin Ali, Dingar, Dharmendra, Sahadevan, Pramod, Hussein, Bahira, Sahmi, Fatiha, Shi, Yanfen, Gillis, Marc-Antoine, Gaestel, Matthias, Tardif, Jean-Claude, Allen, Bruce G

“…MAPK-activated protein kinase-5 (MK5) is a protein serine/threonine kinase that is activated by p38 MAPK and the atypical MAPKs ERK3 and ERK4. The…”
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MK2-Deficient Mice Are Bradycardic and Display Delayed Hypertrophic Remodeling in Response to a Chronic Increase in Afterload by Ruiz, Matthieu, Khairallah, Maya, Dingar, Dharmendra, Vaniotis, George, Khairallah, Ramzi J, Lauzier, Benjamin, Thibault, Simon, Trépanier, Joëlle, Shi, Yanfen, Douillette, Annie, Hussein, Bahira, Nawaito, Sherin Ali, Sahadevan, Pramod, Nguyen, Albert, Sahmi, Fatiha, Gillis, Marc-Antoine, Sirois, Martin G, Gaestel, Matthias, Stanley, William C, Fiset, Céline, Tardif, Jean-Claude, Allen, Bruce G

“…Background Mitogen-activated protein kinase-activated protein kinase-2 (MK2) is a protein serine/threonine kinase activated by p38α/β. Herein, we examine the…”
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G1/S Transcription Factor Orthologues Swi4p and Swi6p Are Important but Not Essential for Cell Proliferation and Influence Hyphal Development in the Fungal Pathogen Candida albicans by Hussein, Bahira, Huang, Hao, Glory, Amandeep, Osmani, Amin, Kaminskyj, Susan, Nantel, Andre, Bachewich, Catherine

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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23-OR: Reduction in Insulin Uncovers a Novel Effect of VEGFB on Cardiac Substrate Utilization by SHANG, RUI, SYNG LEE, CHAE, HUSSEIN, BAHIRA, RODRIGUES, BRIAN

“…VEGFB is known to up-regulate FA delivery through its effect on EC FA transporters. In its absence, intracellular lipid accumulation was reduced…”
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24-OR: Augmented Heparanase Secretion in Diabetes Regulates Development of Cardiac Hypertrophy by SYNG LEE, CHAE, SHANG, RUI, HUSSEIN, BAHIRA, RODRIGUES, BRIAN

“…HSPG consist of a core protein to which several linear heparan sulphate (HS) side chains are linked. Heparanase (Hpa) is exceptional in its ability to degrade…”
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Heparanase Stimulation of Physiologic Cardiac Hypertrophy Is Suppressed After Chronic Diabetes, Resulting in Cardiac Remodeling and Dysfunction by Lee, Chae Syng, Shang, Rui, Wang, Fulong, Khayambashi, Parisa, Wang, Hualin, Araujo, Gala, Puri, Karanjit, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…In addition to controlling smooth muscle tone in coronary vessels, endothelial cells also influence subjacent cardiomyocyte growth. Because heparanase, with…”
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Reduction in Insulin Uncovers a Novel Effect of VEGFB on Cardiac Substrate Utilization by Shang, Rui, Lee, Chae Syng, Wang, Hualin, Dyer, Roger, Noll, Christophe, Carpentier, André, Sultan, Ibrahim, Alitalo, Kari, Boushel, Robert, Hussein, Bahira, Rodrigues, Brian

“…The heart relies heavily on external fatty acid (FA) for energy production. VEGFB (vascular endothelial growth factor B) has been shown to promote endothelial…”
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Heparanase protects the heart against chemical or ischemia/reperfusion injury by Wang, Fulong, Pulinilkunnil, Thomas, Flibotte, Stephane, Nislow, Corey, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…Although cancer cells use heparanase for tumor metastasis, favourable effects of heparanase have been reported in the management of Alzheimer's disease and…”
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Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance by Cen, Haoning Howard, Hussein, Bahira, Botezelli, José Diego, Wang, Su, Zhang, Jiashuo Aaron, Noursadeghi, Nilou, Jessen, Niels, Rodrigues, Brian, Timmons, James A, Johnson, James D

“…Hyperinsulinemia is commonly viewed as a compensatory response to insulin resistance, yet studies have demonstrated that chronically elevated insulin may also…”
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Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart by Shang, Rui, Lal, Nathaniel, Lee, Chae Syng, Zhai, Yajie, Puri, Karanjit, Seira, Oscar, Boushel, Robert C, Sultan, Ibrahim, Räsänen, Markus, Alitalo, Kari, Hussein, Bahira, Rodrigues, Brian

“…Cardiac muscle uses multiple sources of energy including glucose and fatty acid (FA). The heart cannot synthesize FA and relies on obtaining it from other…”
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Loss of VEGFB and its signaling in the diabetic heart is associated with increased cell death signaling by Lal, Nathaniel, Chiu, Amy Pei-Ling, Wang, Fulong, Zhang, Dahai, Jia, Jocelyn, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…Vascular endothelial growth factor B (VEGFB) is highly expressed in metabolically active tissues, such as the heart and skeletal muscle, suggesting a function…”
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Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus by Chiu, Amy Pei-Ling, Wan, Andrea, Lal, Nathaniel, Zhang, Dahai, Wang, Fulong, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…OBJECTIVE—Lipoprotein lipase (LPL)–mediated triglyceride hydrolysis is the major source of fatty acid for cardiac energy. LPL, synthesized in cardiomyocytes,…”
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Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity by Chiu, Amy Pei-Ling, Bierende, Denise, Lal, Nathaniel, Wang, Fulong, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…In the diabetic heart, there is excessive dependence on fatty acid (FA) utilization to generate ATP. Lipoprotein lipase (LPL)-mediated hydrolysis of…”
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High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature by Wang, Fulong, Jia, Jocelyn, Lal, Nathaniel, Zhang, Dahai, Chiu, Amy Pei-Ling, Wan, Andrea, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…The secretion of enzymatically active heparanase (Hep ) has been implicated as an essential metabolic adaptation in the heart following diabetes. However, the…”
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Heparanase Stimulation of Physiological Cardiac Hypertrophy is Suppressed Following Chronic Diabetes Resulting in Cardiac Remodeling and Dysfunction by Lee, Chae Syng, Shang, Rui, Wang, Fulong, Khayambashi, Parisa, Wang, Hualin, Araujo, Gala, Puri, Karanjit, Vlodavsky, Israel, Hussein, Bahira, Rodrigues, Brian

“…Although endothelial cells control smooth muscle tone in coronary vessels, these cells also influence subjacent cardiomyocyte growth. As heparanase, with…”
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Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen After Diabetes by YING WANG, CHIU, Amy Pei-Ling, RODRIGUES, Brian, NEUMAIER, Katharina, FULONG WANG, DAHAI ZHANG, HUSSEIN, Bahira, LAL, Nathaniel, WAN, Andrea, LIU, George, VLODAVSKY, Israel

“…After diabetes, the heart has a singular reliance on fatty acid (FA) for energy production, which is achieved by increased coronary lipoprotein lipase (LPL)…”
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Endothelial cells respond to hyperglycemia by increasing the LPL transporter GPIHBP1 by Pei-Ling Chiu, Amy, Wang, Fulong, Lal, Nathaniel, Wang, Ying, Zhang, Dahai, Hussein, Bahira, Wan, Andrea, Vlodavsky, Israel, Rodrigues, Brian

“…In diabetes, when glucose uptake and oxidation are impaired, the heart is compelled to use fatty acid (FA) almost exclusively for ATP. The vascular content of…”
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