Search Results - "HUSSAIN, S. Perwez"

Inflammation and cancer: An ancient link with novel potentials by Perwez Hussain, S., Harris, Curtis C.

“…Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals,…”
Get full text

Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer by GENG ZHANG, PEIJUN HE, HANNA, Nader, RICHARD ALEXANDER, H, PERWEZ HUSSAIN, S, HANSON TAN, BUDHU, Anuradha, GAEDCKE, Jochen, MICHAEL GHADIMI, B, RIED, Thomas, YFANTIS, Harris G, LEE, Dong H, MAITRA, Anirban

“…To identify metabolic pathways that are perturbed in pancreatic ductal adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of…”
Get full text

A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2 by Yang, Shouhui, He, Peijun, Wang, Jian, Schetter, Aaron, Tang, Wei, Funamizu, Naotake, Yanaga, Katsuhiko, Uwagawa, Tadashi, Satoskar, Abhay R, Gaedcke, Jochen, Bernhardt, Markus, Ghadimi, B Michael, Gaida, Matthias M, Bergmann, Frank, Werner, Jens, Ried, Thomas, Hanna, Nader, Alexander, H Richard, Hussain, S Perwez

“…Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways…”
Get full text

Pancreatic Cancer: Current Progress and Future Challenges by Hussain, S Perwez

“…Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, remains one of the highly lethal malignancies. The highly refractory nature…”
Get full text

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression by Heinecke, Julie L., Ridnour, Lisa A., Cheng, Robert Y. S., Switzer, Christopher H., Lizardo, Michael M., Khanna, Chand, Glynn, Sharon A., Hussain, S. Perwez, Young, Howard A., Ambs, Stefan, Wink, David A.

“…Inflammation is widely recognized as an inducer of cancer progression. The inflammation-associated enzyme, inducible nitric oxide synthase (NOS2), has emerged…”
Get full text

NO • and Pancreatic Cancer: A Complex Interaction with Therapeutic Potential by Wang, Jian, Hussain, S Perwez

“…Pancreatic tumors express high level of nitric oxide synthases (NOSs) in particular inducible (iNOS/NOS2) and endothelial (eNOS/NOS3) forms. However, the role…”
Get more information

Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma by Funamizu, Naotake, Hu, Chaoxin, Lacy, Curtis, Schetter, Aaron, Zhang, Geng, He, Peijun, Gaedcke, Jochen, Ghadimi, Michael B., Ried, Thomas, Yfantis, Harris G., Lee, Dong H., Subleski, Jeffrey, Chan, Tim, Weiss, Jonathan M., Back, Timothy C., Yanaga, Katsuhiko, Hanna, Nader, Alexander, H. Richard, Maitra, Anirban, Hussain, S. Perwez

“…MIF is a proinflammatory cytokine and is implicated in cancer. A higher MIF level is found in many human cancer and cancer‐prone inflammatory diseases,…”
Get full text

SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer by Ohara, Yuuki, Tang, Wei, Liu, Huaitian, Yang, Shouhui, Dorsey, Tiffany H., Cawley, Helen, Moreno, Paloma, Chari, Raj, Guest, Mary R., Azizian, Azadeh, Gaedcke, Jochen, Ghadimi, Michael, Hanna, Nader, Ambs, Stefan, Hussain, S. Perwez

“…Pancreatic ductal adenocarcinoma (PDAC) exhibits distinct molecular subtypes: classical/progenitor and basal-like/squamous. Our study aimed to identify genes…”
Get full text

NOS2 enhances KRAS‐induced lung carcinogenesis, inflammation and microRNA‐21 expression by Okayama, Hirokazu, Saito, Motonobu, Oue, Naohide, Weiss, Jonathan M., Stauffer, Jimmy, Takenoshita, Seiichi, Wiltrout, Robert H., Hussain, S. Perwez, Harris, Curtis C.

“…Mutant KRAS in lung cancers induces molecular pathways that regulate cellular proliferation, survival and inflammation, which enhance tumorigenesis. Inducible…”
Get full text

Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production by Baseler, Walter A, Davies, Luke C, Quigley, Laura, Ridnour, Lisa A, Weiss, Jonathan M, Hussain, S Perwez, Wink, David A, McVicar, Daniel W

“…Inflammatory maturation of M1 macrophages by proinflammatory stimuli such as toll like receptor ligands results in profound metabolic reprogramming resulting…”
Get full text

A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells by Li, Xiao Ling, Pongor, Lőrinc, Tang, Wei, Das, Sudipto, Muys, Bruna R, Jones, Matthew F, Lazar, Sarah B, Dangelmaier, Emily A, Hartford, Corrine Cr, Grammatikakis, Ioannis, Hao, Qinyu, Sun, Qinyu, Schetter, Aaron, Martindale, Jennifer L, Tang, BinWu, Jenkins, Lisa M, Robles, Ana I, Walker, Robert L, Ambs, Stefan, Chari, Raj, Shabalina, Svetlana A, Gorospe, Myriam, Hussain, S Perwez, Harris, Curtis C, Meltzer, Paul S, Prasanth, Kannanganattu V, Aladjem, Mirit I, Andresson, Thorkell, Lal, Ashish

“…Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding potential. However, only a handful of endogenous proteins encoded by…”
Get full text

Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy by Parker, Amelia L, Toulabi, Leila, Oike, Takahiro, Kanke, Yasuyuki, Patel, Daxeshkumar, Tada, Takeshi, Taylor, Sheryse, Beck, Jessica A, Bowman, Elise, Reyzer, Michelle L, Butcher, Donna, Kuhn, Skyler, Pauly, Gary T, Krausz, Kristopher W, Gonzalez, Frank J, Hussain, S. Perwez, Ambs, Stefan, Ryan, Brid M, Wang, Xin Wei, Harris, Curtis C

“…The metabolic dependencies of cancer cells have substantial potential to be exploited to improve the diagnosis and treatment of cancer. Creatine riboside (CR)…”
Get full text

Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide by Mathé, Ewy, Nguyen, Giang H., Funamizu, Naotake, He, Peijun, Moake, Matthew, Croce, Carlo M., Hussain, S. Perwez

“…microRNA (miRNA) are small non‐coding RNA targeting mRNAs leading to their instability and diminished translation. Altered expression of miRNA is associated…”
Get full text

Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer by Wang, Jian, Yang, Shouhui, He, Peijun, Schetter, Aaron J, Gaedcke, Jochen, Ghadimi, B Michael, Ried, Thomas, Yfantis, Harris G, Lee, Dong H, Gaida, Matthias M, Hanna, Nader, Alexander, H Richard, Hussain, S Perwez

“…Pancreatic ductal adenocarcinoma (PDAC) is refractory to available treatments. Delineating critical pathways, responsible for disease aggressiveness and…”
Get full text

Metabolic profiles are principally different between cancers of the liver, pancreas and breast by Budhu, Anuradha, Terunuma, Atsushi, Zhang, Geng, Hussain, S Perwez, Ambs, Stefan, Wang, Xin Wei

“…Molecular profiling of primary tumors may facilitate the classification of patients with cancer into more homogenous biological groups to aid clinical…”
Get full text

Nitric Oxide Is a Key Component in Inflammation-Accelerated Tumorigenesis by PERWEZ HUSSAIN, S, PEIJUN HE, MATHE, Ewy, DJURICKOVIC, Draginja, HAINES, Diana, WEISS, Jonathan, BACK, Timothy, GRUYS, Eilene, LAUBACH, Victor E, WILTROUT, Robert H, HARRIS, Curtis C, SUBLESKI, Jeffery, HOFSETH, Lorne J, TRIVERS, Glenwood E, MECHANIC, Leah, HOFSETH, Anne B, BERNARD, Mark, SCHWANK, Jonathan, NGUYEN, Giang

“…Nitric oxide (NO(*)), an important signaling molecule and a component of inflammatory response, is involved in tumorigenesis. However, the quantity of NO(*)…”
Get full text

Deciphering The Complex Biological Interactions Of Nitric Oxide In Cancer by Perwez Hussain, S

“…NO is a free radical and is involved in a number of critical physiological processes including vasodilation, neurotransmission, immune regulation and…”
Get full text

Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer by Quadri, Humair S, Aiken, Taylor J, Allgaeuer, Michael, Moravec, Radim, Altekruse, Sean, Hussain, S Perwez, Miettinen, Markku M, Hewitt, Stephen M, Rudloff, Udo

“…Despite the near universal occurrence of activating codon 12 KRAS somatic variants in pancreatic cancer, there is considerable heterogeneity in the molecular…”
Get full text

Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy by Weiss, Jonathan M, Ridnour, Lisa A, Back, Tim, Hussain, S Perwez, He, Peijun, Maciag, Anna E, Keefer, Larry K, Murphy, William J, Harris, Curtis C, Wink, David A, Wiltrout, Robert H

“…Using an orthotopic model of renal cell carcinoma, we showed previously that IL-2/anti-CD40 immunotherapy resulted in synergistic anti-tumor responses, whereas…”
Get full text

Nitric Oxide-Induced Cellular Stress and p53 Activation in Chronic Inflammation by Hofseth, Lorne J., Saito, Shin'ichi, Hussain, S. Perwez, Espey, Michael G., Miranda, Katrina M., Araki, Yuzuru, Jhappan, Chamelli, Higashimoto, Yuichiro, He, Peijun, Linke, Steven P., Quezado, Martha M., Zurer, Irit, Rotter, Varda, Wink, David A., Appella, Ettore, Harris, Curtis C.

“…Free radical-induced cellular stress contributes to cancer during chronic inflammation. Here, we investigated mechanisms of p53 activation by the free radical,…”
Get full text