Search Results - "HUSSAIN, Azhar R"

Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis by Hussain, Azhar R, Ahmed, Saeeda O, Ahmed, Maqbool, Khan, Omar S, Al Abdulmohsen, Sally, Platanias, Leonidas C, Al-Kuraya, Khawla S, Uddin, Shahab

“…A number of constitutively activated signaling pathways play critical roles in the survival and growth of primary effusion lymphoma cells (PELs) including NFkB…”
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XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis by Hussain, Azhar R, Siraj, Abdul Khalid, Ahmed, Maqbool, Bu, Rong, Pratheeshkumar, Poyil, Alrashed, Alanood M, Qadri, Zeeshan, Ajarim, Dahish, Al-Dayel, Fouad, Beg, Shaham, Al-Kuraya, Khawla S

“…Breast cancer is the most common cancer in females and is ranked second in cancer-related deaths all over the world in women. Despite improvement in diagnosis,…”
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Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines by Hussain, Azhar R, Uddin, Shahab, Bu, Rong, Khan, Omar S, Ahmed, Saeeda O, Ahmed, Maqbool, Al-Kuraya, Khawla S

“…We have recently shown that deregulation PI3-kinase/AKT survival pathway plays an important role in pathogenesis of diffuse large B cell lymphoma (DLBCL). In…”
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Role of phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival by Uddin, Shahab, Hussain, Azhar R., Siraj, Abdul K., Manogaran, Pulicat S., Al-Jomah, Naif A., Moorji, Azadali, Atizado, Valerie, Al-Dayel, Fouad, Belgaumi, Asim, El-Solh, Hassan, Ezzat, Adnan, Bavi, Prashant, Al-Kuraya, Khawla S.

“…Phosphatidylinositol 3′-kinase (PI3K) is a key player in cell-growth signaling in a number of lymphoid malignancies, but its role in diffuse large B-cell…”
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Curcumin suppresses constitutive activation of nuclear factor-κB and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines by Hussain, Azhar R, Ahmed, Maqbool, Al-Jomah, Naif A, Khan, Asma S, Manogaran, Pulicat, Sultana, Mehar, Abubaker, Jehad, Platanias, Leonidas C, Al-Kuraya, Khawla S, Uddin, Shahab

“…We provide evidence that curcumin, a natural compound isolated from rhizomes of plant Curcuma longa , induces apoptosis in several Burkitt's lymphoma cell…”
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Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release by Hussain, Azhar R, Uddin, Shahab, Ahmed, Maqbool, Al-Dayel, Fouad, Bavi, Prashant P, Al-Kuraya, Khawla S

“…Activated B-cell lymphoma (ABC), one of the three subtypes of Diffuse Large B-cell Lymphoma (DLBCL) has the worst survival rate after upfront chemotherapy and…”
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Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells by HUSSAIN, Azhar R, AL-JOMAH, Naif A, SIRAJ, Abdul K, MANOGARAN, Pulicat, AL-HUSSEIN, Khalid, ABUBAKER, Jehad, PLATANIAS, Leonidas C, AL-KURAYA, Khawla S, UDDIN, Shahab

“…Primary effusion lymphoma (PEL) is an incurable, aggressive B-cell malignancy that develops rapid resistance to conventional chemotherapy. In efforts to…”
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Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma by UDDIN, Shahab, HUSSAIN, Azhar R, AHMED, Maqbool, SIDDIQUI, Khawar, AI-DAYEL, Fouad, BAVI, Prashant, AL-KURAYA, Khawla S

“…FoxM1 has been shown to play a critical role in the pathogenesis of various epithelial malignancies. However, its role in lymphoid malignancies has not been…”
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Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma by Uddin, Shahab, Bavi, Prashant, Siraj, Abdul K, Ahmed, Maqbool, Al-Rasheed, Maha, Hussain, Azhar R, Ahmed, Mohammed, Amin, Tarek, Alzahrani, Ali, Al-Dayel, Fouad, Abubaker, Jehad, Bu, Rong, Al-Kuraya, Khawla S

“…The putative role of leptin and its receptor (Ob-R) in the pathogenesis of various primary human malignancies has been reported; however, their role in…”
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Fatty Acid Synthase and AKT Pathway Signaling in a Subset of Papillary Thyroid Cancers by Uddin, Shahab, Siraj, Abdul K., Al-Rasheed, Maha, Ahmed, Maqbool, Bu, Rong, Myers, Jeffrey N., Al-Nuaim, Abdulrahman, Al-Sobhi, Saif, Al-Dayel, Fouad, Bavi, Prashant, Hussain, Azhar R., Al-Kuraya, Khawla S.

“…Context: Fatty acid synthase (FASN) is an enzyme that plays a critical role in de novo synthesis of fatty acids. FASN is overexpressed in variety of human…”
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HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma by Bu, Rong, Uddin, Shahab, Bavi, Prashant, Hussain, Azhar R, Al-Dayel, Fouad, Ghourab, Samir, Ahmed, Maqbool, Al-Kuraya, Khawla S

“…The Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), are overexpressed and/or activated in a variety of human malignancies…”
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Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma by UDDIN, Shahab, HUSSAIN, Azhar R, MANOGARAN, Pulicat S, AL-HUSSEIN, Khaled, PLATANIAS, Leonidas C, GUTIERREZ, Marina I, BHATIA, Kishor G

“…The mechanisms that regulate induction of the antiapoptotic state and mitogenic signals in primary effusion lymphoma (PEL) are not well known. In efforts to…”
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High Prevalence of Fatty Acid Synthase Expression in Colorectal Cancers in Middle Eastern Patients and Its Potential Role as a Therapeutic Target by UDDIN, Shahab, HUSSAIN, Azhar R, AL-KURAYA, Khawla S, AHMED, Maqbool, ABUBAKER, Jehad, AL-SANEA, Nasser, ABDULJABBAR, Alaa, ASHARI, Luai H, ALHOMOUD, Samar, AL-DAYEL, Fouad, BAVI, Prashant

“…Many human epithelial cancers, particularly those with a poor prognosis, express high levels of fatty acid synthase (FASN), a key metabolic enzyme linked to…”
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Inhibition of Phosphatidylinositol 3′-Kinase/AKT Signaling Promotes Apoptosis of Primary Effusion Lymphoma Cells by UDDIN, Shahab, HUSSAIN, Azhar R, AL-HUSSEIN, Khaled A, MANOGARAN, Pulicat S, WICKREMA, Amitha, GUTIERREZ, Marina I, BHATIA, Kishor G

“…Purpose: Phosphatidylinositol 3′-kinase (PI3′-kinase) can be activated by the K1 protein of Kaposi sarcoma–associated herpes virus (KSHV). However, the role of…”
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Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations by Bavi, Prashant, Prabhakaran, Sarita E, Abubaker, Jehad, Qadri, Zeeshan, George, Thara, Al-Sanea, Nasser, Abduljabbar, Alaa, Ashari, Luai H, Alhomoud, Samar, Al-Dayel, Fouad, Hussain, Azhar R, Uddin, Shahab, Al-Kuraya, Khawla S

“…Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumour necrosis factor cytokine family that induces apoptosis upon binding…”
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Role of X-Linked Inhibitor of Apoptosis as a Prognostic Marker and Therapeutic Target in Papillary Thyroid Carcinoma by Hussain, Azhar R, Bu, Rong, Ahmed, Maqbool, Jehan, Zeenath, Beg, Shaham, Al-Sobhi, Saif, Al-Dayel, Fouad, Siraj, Abdul K, Uddin, Shahab, Al-Kuraya, Khawla S

“…Context: Papillary thyroid cancer (PTC) is the second most common cancer in females in Saudi Arabia. However, the pathogenesis of PTC is still not fully…”
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Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma by Hussain, Azhar R., Ahmed, Maqbool, Ahmed, Saeeda, Manogaran, Pulicat, Platanias, Leonidas C., Alvi, Syed N., Al-Kuraya, Khawla S., Uddin, Shahab

“…We provide evidence that thymoquinone (TQ), a natural compound isolated from Nigella sativa, induces growth inhibition and apoptosis in several primary…”
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High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma by Ahmed, Maqbool, Hussain, Azhar R, Bavi, Prashant, Ahmed, Saeeda O, Al Sobhi, Saif S, Al-Dayel, Fouad, Uddin, Shahab, Al-Kuraya, Khawla S

“…The mammalian target of rapamycin (mTOR) signaling cascade is a key regulatory pathway controlling initiation of messenger RNA in mammalian cells. Although…”
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FoxM1 and Its Association with Matrix Metalloproteinases (MMP) Signaling Pathway in Papillary Thyroid Carcinoma by Ahmed, Maqbool, Uddin, Shahab, Hussain, Azhar R, Alyan, Aisha, Jehan, Zeenath, Al-Dayel, Fouad, Al-Nuaim, Abdulrehman, Al-Sobhi, Saif, Amin, Tarek, Bavi, Prashant, Al-Kuraya, Khawla S

“…Context: Forkhead boxM1 (FoxM1) transcription factor has been shown to promote pathogenesis of several malignancies. FoxM1 has also been shown to be associated…”
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Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells by Ahmed, Maqbool, Hussain, Azhar R, Siraj, Abdul K, Uddin, Shahab, Al-Sanea, Nasser, Al-Dayel, Fouad, Al-Assiri, Mohammed, Beg, Shaham, Al-Kuraya, Khawla S

“…Cross-talk between deregulated signaling pathways in cancer cells causes uncontrolled growth and proliferation. These cancers cells become more aggressive and…”
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