Search Results - "HUSHENG DING"

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age by Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R., Pirtskhalava, Tamar, White, Thomas A., Johnson, Kurt O., Stout, Michael B., Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D., LeBrasseur, Nathan K., Kirkland, James L.

“…Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of…”
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Targeting senescent cells enhances adipogenesis and metabolic function in old age by Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L

“…Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy…”
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Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance by HAIMING DAI, HUSHENG DING, WEI MENG, X, LEE, Sun-Hee, SCHNEIDER, Paula A, KAUFMANN, Scott H

“…Bcl-2 is phosphorylated on Ser(70) after treatment of cells with spindle poisons. On the basis of effects observed in cells overexpressing Bcl-2 S70E or S70A…”
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Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells by Dai, Haiming, Ding, Husheng, Meng, X Wei, Peterson, Kevin L, Schneider, Paula A, Karp, Judith E, Kaufmann, Scott H

“…Mitochondrial outer membrane permeabilization (MOMP), a key step in the intrinsic apoptotic pathway, is incompletely understood. Current models emphasize the…”
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Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors by Venkatachalam, Annapoorna, Correia, Cristina, Peterson, Kevin L, Hou, Xianon, Schneider, Paula A, Strathman, Annabella R, Flatten, Karen S, Sine, Chance C, Balczewski, Emily A, McGehee, Cordelia D, Larson, Melissa C, Duffield, Laura N, Meng, X Wei, Vincelette, Nicole D, Ding, Husheng, Oberg, Ann L, Couch, Fergus J, Swisher, Elizabeth M, Li, Hu, Weroha, S John, Kaufmann, Scott H

“…Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid…”
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Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo by Vincelette, Nicole D., Ding, Husheng, Huehls, Amelia M., Flatten, Karen S., Kelly, Rebecca L., Kohorst, Mira A., Webster, Jonathan, Hess, Allan D., Pratz, Keith W., Karnitz, Larry M., Kaufmann, Scott H.

“…CPX-351 is a liposomally encapsulated 5:1 molar ratio of cytarabine and daunorubicin that recently received regulatory approval for the treatment of…”
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Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3 by CHUANHAI FU, AHMED, Kashif, HE HUANG, XUEBIAO YAO, HUSHENG DING, XIA DING, JIANPING LAN, ZHIHONG YANG, YONG MIAO, YUANYUAN ZHU, YUNYU SHI, JINGDE ZHU

“…The PML gene of acute promyelocytic leukemia (APL) encodes a cell-growth and tumor suppressor. PML localizes to discrete nuclear bodies (NBs) that are…”
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Diversity of post-translational modifications and cell signaling revealed by single cell and single organelle mass spectrometry by Mun, Dong-Gi, Bhat, Firdous A., Joshi, Neha, Sandoval, Leticia, Ding, Husheng, Jain, Anu, Peterson, Jane A., Kang, Taewook, Pujari, Ganesh P., Tomlinson, Jennifer L., Budhraja, Rohit, Zenka, Roman M., Kannan, Nagarajan, Kipp, Benjamin R., Dasari, Surendra, Gaspar-Maia, Alexandre, Smoot, Rory L., Kandasamy, Richard K., Pandey, Akhilesh

“…The rapid evolution of mass spectrometry-based single-cell proteomics now enables the cataloging of several thousand proteins from single cells. We…”
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Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas by Witzig, Thomas E., Tang, Hui, Micallef, Ivana N.M., Ansell, Stephen M., Link, Brian K., Inwards, David J., Porrata, Luis F., Johnston, Patrick B., Colgan, Joseph P., Markovic, Svetomir N., Nowakowski, Grzegorz S., Thompson, Carrie A., Allmer, Cristine, Maurer, Matthew J., Gupta, Mamta, Weiner, George, Hohl, Ray, Kurtin, Paul J., Ding, Husheng, Loegering, David, Schneider, Paula, Peterson, Kevin, Habermann, Thomas M., Kaufmann, Scott H.

“…A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib was conducted in 93 adult patients with relapsed or refractory lymphoma. Patients received…”
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Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation by Ding, Husheng, Hackbarth, Jennifer, Schneider, Paula A., Peterson, Kevin L., Meng, X. Wei, Dai, Haiming, Witzig, Thomas E., Kaufmann, Scott H.

“…The mechanism of cytotoxicity of farnesyltransferase inhibitors is incompletely understood and seems to vary depending on the cell type. To identify potential…”
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SUMO-1 modification increases human SOD1 stability and aggregation by Fei, Erkang, Jia, Nali, Yan, Ming, Ying, Zheng, Sun, Qiang, Wang, Hongfeng, Zhang, Tao, Ma, Xiaochuan, Ding, Husheng, Yao, Xuebiao, Shi, Yunyu, Wang, Guanghui

“…The mutations in the gene encoding copper–zinc superoxide dismutase (SOD1) cause approximately 20% cases of familial amyotrophic lateral sclerosis (FALS),…”
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Selection of Single Chain Fragment Variables with Direct Coating of Aflatoxin B1 to Enzyme-Linked Immunosorbent Assay Plates by Yang, Lian, Ding, Husheng, Gu, Zhennan, Zhao, Jianxin, Chen, Haiqin, Tian, Fengwei, Chen, Yong Q, Zhang, Hao, Chen, Wei

“…Most selections of antihapten recombinant antibodies from antibody libraries were against hapten-carrier conjugates, which are different from free haptens in…”
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Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells by Ding, Husheng, McDonald, Jennifer S, Yun, Seongseok, Schneider, Paula A, Peterson, Kevin L, Flatten, Karen S, Loegering, David A, Oberg, Ann L, Riska, Shaun M, Huang, Shengbing, Sinicrope, Frank A, Adjei, Alex A, Karp, Judith E, Meng, X Wei, Kaufmann, Scott H

“…Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism…”
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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs by Zhu, Yi, Tchkonia, Tamara, Pirtskhalava, Tamar, Gower, Adam C., Ding, Husheng, Giorgadze, Nino, Palmer, Allyson K., Ikeno, Yuji, Hubbard, Gene B., Lenburg, Marc, O'Hara, Steven P., LaRusso, Nicholas F., Miller, Jordan D., Roos, Carolyn M., Verzosa, Grace C., LeBrasseur, Nathan K., Wren, Jonathan D., Farr, Joshua N., Khosla, Sundeep, Stout, Michael B., McGowan, Sara J., Fuhrmann‐Stroissnigg, Heike, Gurkar, Aditi U., Zhao, Jing, Colangelo, Debora, Dorronsoro, Akaitz, Ling, Yuan Yuan, Barghouthy, Amira S., Navarro, Diana C., Sano, Tokio, Robbins, Paul D., Niedernhofer, Laura J., Kirkland, James L.

“…Summary The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a…”
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Getting a GRP on histone deacetylase inhibitor selectivity by Ding, Husheng, Correia, Cristina, Kaufmann, Scott

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Automated Sample Preparation Workflow for Tandem Mass Tag-Based Proteomics by Mun, Dong-Gi, Joshi, Neha S., Budhraja, Rohit, Sachdeva, Gunveen S., Kang, Taewook, Bhat, Firdous A., Ding, Husheng, Madden, Benjamin J., Zhong, Jun, Pandey, Akhilesh

“…Although tandem mass tag (TMT)-based isobaric labeling has become a powerful approach for multiplexed protein quantitation, automating the workflow for this…”
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Exploration of Nitrotyrosine-Containing Proteins and Peptides by Antibody-Based Enrichment Strategies by Bhat, Firdous A., Mangalaparthi, Kiran K., Ding, Husheng, Jain, Anu, Hsu, Joel-Sean, Peterson, Jane A., Zenka, Roman M., Mun, Dong-Gi, Kandasamy, Richard K., Pandey, Akhilesh

“…Nitrotyrosine, or 3-nitrotyrosine, is an oxidative post-translational modification induced by reactive nitrogen species. Although nitrotyrosine is considered a…”
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BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma by Correia, Cristina, Schneider, Paula A., Dai, Haiming, Dogan, Ahmet, Maurer, Matthew J., Church, Amy K., Novak, Anne J., Feldman, Andrew L., Wu, Xiaosheng, Ding, Husheng, Meng, X. Wei, Cerhan, James R., Slager, Susan L., Macon, William R., Habermann, Thomas M., Karp, Judith E., Gore, Steven D., Kay, Neil E., Jelinek, Diane F., Witzig, Thomas E., Nowakowski, Grzegorz S., Kaufmann, Scott H.

“…Follicular lymphoma (FL), an indolent neoplasm caused by a t(14;18) chromosomal translocation that juxtaposes the BCL2 gene and immunoglobulin locus, has a…”
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Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma by Kanakkanthara, Arun, Hou, Xiaonan, Ekstrom, Thomas L, Zanfagnin, Valentina, Huehls, Amelia M, Kelly, Rebecca L, Ding, Husheng, Larson, Melissa C, Vasmatzis, George, Oberg, Ann L, Kaufmann, Scott H, Mansfield, Aaron S, Weroha, S John, Karnitz, Larry M

“…PARP inhibitors (PARPi) have activity in homologous recombination (HR) repair-deficient, high-grade serous ovarian cancers (HGSOC). However, even responsive…”
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Measurement of BH3-only protein tolerance by Dai, Haiming, Ding, Husheng, Peterson, Kevin L, Meng, X Wei, Schneider, Paula A, Knorr, Katherine L B, Kaufmann, Scott H

“…The BCL2 family of proteins regulates cellular life and death decisions. Among BCL2 family members, BH3-only proteins have critical roles by neutralizing…”
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