Search Results - "HUSEBY, E. S"

A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis by Huseby, E S, Liggitt, D, Brabb, T, Schnabel, B, Ohlén, C, Goverman, J

“…Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4(+) and CD8(+) T cells…”
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Granulocyte-macrophage colony-stimulating factor : An effective adjuvant for protein and peptide-based vaccines by DISIS, M. L, BERNHARD, H, SHIOTA, F. M, HAND, S. L, GRALOW, J. R, HUSEBY, E. S, GILLIS, S, CHEEVER, M. A

“…The current studies evaluate granulocyte-macrophage colony-stimulating factor (GM-CSF) as a vaccine adjuvant. An important issue for developing vaccine therapy…”
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Antibody to ras proteins in patients with colon cancer by TAKAHASHI, M, WEI CHEN, YASUTOMI, M, PEACE, D. J, CHEEVER, M. A, BYRD, D. R, DISIS, M. L, HUSEBY, E. S, HUILIAN QIN, MCCAHILL, L, NELSON, H, SHIMADA, H, OKUNO, K

“…The current study examined sera from 160 colon cancer patients and 60 normal individuals to determine whether antibody to mutated p21 ras protein was present…”
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Age-Dependent T Cell Tolerance and Autoimmunity to Myelin Basic Protein by Huseby, Eric S., Sather, Blythe, Huseby, Priya G., Goverman, Joan

“…Experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, is induced by activating a subset of myelin basic protein…”
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Negative Selection Imparts Peptide Specificity to the Mature T Cell Repertoire by Huseby, Eric S., Crawford, Frances, White, Janice, Kappler, John, Marrack, Philippa

“…The T cell αβ receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the…”
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Immunity to oncogenic proteins by Cheever, M A, Disis, M L, Bernhard, H, Gralow, J R, Hand, S L, Huseby, E S, Qin, H L, Takahashi, M, Chen, W

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Tolerating the nervous system: a delicate balance by Huseby, E S, Goverman, J

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Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling by Wucherpfennig, Kai W, Gagnon, Etienne, Call, Melissa J, Huseby, Eric S, Call, Matthew E

“…The T-cell receptor (TCR)-CD3 complex serves as a central paradigm for general principles of receptor assembly, ligand recognition, and signaling in the immune…”
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Exacerbation of Mycobacterium tuberculosis enteritis masquerading as Crohn's disease after treatment with a tumor necrosis factor-alpha inhibitor by Wagner, Teresa E, Huseby, Eric S, Huseby, Jon S

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Polyspecificity of T cell and B cell receptor recognition by Wucherpfennig, Kai W, Allen, Paul M, Celada, Franco, Cohen, Irun R, De Boer, Rob, Garcia, K. Christopher, Goldstein, Byron, Greenspan, Ralph, Hafler, David, Hodgkin, Philip, Huseby, Erik S, Krakauer, David C, Nemazee, David, Perelson, Alan S, Pinilla, Clemencia, Strong, Roland K, Sercarz, Eli E

“…Abstract A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this…”
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Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions by Brabb, T, Huseby, E S, Morgan, T M, Sant'Angelo, D B, Kirchner, J, Farr, A G, Goverman, J

“…The thymic architecture is normally compartmentalized into a central medulla surrounded by a peripheral cortical region. We investigated how…”
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Dendritic Cells Lose Ability to Present Protein Antigen after Stimulating Antigen-Specific T Cell Responses, despite Upregulation of MHC Class II Expression by Bernhard, Helga, Huseby, Eric S., Hand, Susan L., Lohmann, Matthias, Batten, Wendy Y., Disis, Mary L., Gralow, Julie R., Büschenfelde, Karl-Hermann Meyer Zum, Öhlen, Claes, Cheever, Martin A.

“…Immature dendritic cells (DC) take up, process and present protein antigens; mature DC are specialized for stimulating primary T cell responses with increased…”
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How the T Cell Repertoire Becomes Peptide and MHC Specific by Huseby, Eric S., White, Janice, Crawford, Frances, Vass, Tibor, Becker, Dean, Pinilla, Clemencia, Marrack, Philippa, Kappler, John W.

“…T cells bearing αβ T cell receptors (TCRs) recognize antigens in the form of peptides bound to class I or class II major histocompatibility proteins (MHC)…”
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In vitro priming to tumor-associated proteins by Hand, S L, Bernhard, H, Huseby, E S, Rubin, W D, Disis, M L, Cheever, M A

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Myelin Basic Protein-Specific Cytotoxic T Cell Tolerance Is Maintained In Vivo by a Single Dominant Epitope in H-2 super(k) Mice by Huseby, E S, Oehlen, C, Goverman, J

“…Multiple sclerosis (MS) is believed to be an autoimmune disease mediated by T cells specific for CNS Ags. MS lesions contain both CD4 super(+) and CD8 super(+)…”
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Polymorphisms in the Cytotoxic T Lymphocyte Antigen-4 Gene Region Confer Susceptibility to Addison’s Disease by Blomhoff, Anne, Lie, Benedicte A., Myhre, Anne G., Kemp, E. Helen, Weetman, Anthony P., Akselsen, Hanne E., Huseby, Eystein S., Undlien, Dag E.

“…The cytotoxic T lymphocyte antigen-4 (CTLA4) gene on chromosome 2q33 encodes a key regulator in the adaptive immune system. The CTLA4 surface molecule is…”
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A Pathogenic Role for Myelin-specific CD8 super(+) T Cells in a Model for Multiple Sclerosis by Huseby, E S, Liggitt, D, Brabb, T, Schnabel, B, Oehlen, C, Goverman, J

“…Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4 super(+) and CD8 super(+) T…”
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TCR signaling regulates thymic organization: lessons from TCR-transgenic mice by Goverman, Joan, Brabb, Thea, Huseby, Eric S., Farr, Andrew G.

“…Recently described changes in thymic architecture in a variety of T-cell receptor (TCR)-transgenic mouse models have implications for our understanding of the…”
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CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function by Ohlén, Claes, Kalos, Michael, Cheng, Laurence E, Shur, Aaron C, Hong, Doley J, Carson, Bryan D, Kokot, Niels C T, Lerner, Cara G, Sather, Blythe D, Huseby, Eric S, Greenberg, Philip D

“…CD8+ T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generating T cell responses to tumor-associated antigens. We have…”
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CD8 super(+) T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function by Oehlen, C, Kalos, M, Cheng, LE, Shur, A C, Hong, D J, Carson, B D, Kokot, NCT, Lerner, C G, Sather, B D, Huseby, E S, Greenberg, P D

“…CD8 super(+) T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generating T cell responses to tumor-associated antigens. We…”
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