Search Results - "HURST, Susan"

Analysis of β-nerve growth factor and its precursor during human pregnancy by immunoaffinity-liquid chromatography tandem mass spectrometry by Walsh, Jason, Palandra, Joe, Goihberg, Eduward, Deng, Shibing, Hurst, Susan, Neubert, Hendrik

“…β-Nerve growth factor (NGF) is a neurotrophin that plays a critical role in fetal development during gestation. ProNGF is the precursor form of NGF with a…”
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Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model by LaBranche, Timothy P, Bendele, Alison M, Omura, Brian C, Gropp, Kathryn E, Hurst, Susan I, Bagi, Cedo M, Cummings, Thomas R, Grantham, 2nd, Lonnie E, Shelton, David L, Zorbas, Mark A

“…To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly…”
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Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction by Fahmi, Odette A, Hurst, Susan, Plowchalk, David, Cook, Jack, Guo, Feng, Youdim, Kuresh, Dickins, Maurice, Phipps, Alex, Darekar, Amanda, Hyland, Ruth, Obach, R Scott

“…Cytochrome P450 3A4 (CYP3A4) is the most important enzyme in drug metabolism and because it is the most frequent target for pharmacokinetic drug-drug…”
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Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments by Gropp, Kathryn E., Carlson, Cathy S., Evans, Mark G., Bagi, Cedo M., Reagan, William J., Hurst, Susan I., Shelton, David L., Zorbas, Mark A.

“…Tanezumab, an anti-nerve growth factor (NGF) antibody, is in development for management of chronic pain. During clinical trials of anti-NGF antibodies, some…”
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Serum β-nerve growth factor concentrations in pregnant female, nonpregnant female, and male cynomolgus monkeys by NEUBERT, Hendrik, CLARK, Tracey H, SHIBING DENG, HURST, Susan I

“…Serum β-nerve growth factor (NGF) concentrations were determined in pregnant female, nonpregnant female, and male cynomolgus monkeys using a highly selective…”
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Comparative Nonclinical Assessments of the Proposed Biosimilar PF-05280586 and Rituximab (MabThera®) by Ryan, Anne M., Sokolowski, Sharon A., Ng, Chee-Keng, Shirai, Norimitsu, Collinge, Mark, Shen, Amy C., Arrington, Joshua, Radi, Zaher, Cummings, Thomas R., Ploch, Stephen A., Stephenson, Sarah A., Tripathi, Niraj K., Hurst, Susan I., Finch, Gregory L., Leach, Michael W.

“…Comparative nonclinical studies were conducted with the proposed biosimilar PF-05280586 and rituximab-EU (MabThera®). In side-by-side analyses, peptide maps…”
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Quantitative Prediction of Renal Transporter-Mediated Clinical Drug–Drug Interactions by Feng, Bo, Hurst, Susan, Lu, Yasong, Varma, Manthena V, Rotter, Charles J, El-Kattan, Ayman, Lockwood, Peter, Corrigan, Brian

“…Kidney plays a critical role in the elimination of xenobiotics. Drug–drug interactions (DDIs) via inhibition of renal organic anion (OAT) and organic cation…”
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Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans by Hurst, Susan, Loi, Cho-Ming, Brodfuehrer, Joanne, El-Kattan, Ayman

“…The onset, intensity and duration of therapeutic response to a compound depend on the intrinsic pharmacological activity of the drug and pharmacokinetic…”
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From the Cover: Evaluation of the Effects of Tanezumab, a Monoclonal Antibody Against Nerve Growth Factor, on the Sympathetic Nervous System in Adult Cynomolgus Monkeys (Macaca fascicularis): A Stereologic, Histomorphologic, and Cardiofunctional Assessment by Belanger, Patrice, Butler, Paul, Butt, Mark, Bhatt, Siddhartha, Foote, Stephen, Shelton, David, Evans, Mark, Arends, Rosalinda, Hurst, Susan, Okerberg, Carlin, Cummings, Thomas, Potter, David, Steidl-Nichols, Jill, Zorbas, Mark

“…Tanezumab, a humanized monoclonal antibody against nerve growth factor is in development for treatment of chronic pain. Three nonclinical studies assessed…”
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Book Lovers, Technophiles, Pragmatists, and Printers: The Social and Demographic Structure of User Attitudes toward E-Books by Revelle, Andy, Messner, Kevin, Shrimplin, Aaron, Hurst, Susan

“…Q-methodology was used to identify clusters of opinions about e-books at Miami University. The research identified four distinct opinion types among those…”
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Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction by Youdim, Kuresh A., Zayed, Aref, Dickins, Maurice, Phipps, Alex, Griffiths, Michelle, Darekar, Amanda, Hyland, Ruth, Fahmi, Odette, Hurst, Susan, Plowchalk, David R., Cook, Jack, Guo, Feng, Obach, R. Scott

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Numerous retrospective analyses have shown the utility of in vitro systems for predicting potential drug–drug…”
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Atorvastatin Glucuronidation Is Minimally and Nonselectively Inhibited by the Fibrates Gemfibrozil, Fenofibrate, and Fenofibric Acid by GOOSEN, Theunis C, BAUMAN, Jonathan N, DAVIS, John A, YU, Chongwoo, HURST, Susan I, WILLIAMS, J. Andrew, LOI, Cho-Ming

“…Gemfibrozil coadministration generally results in plasma statin area under the curve (AUC) increases, ranging from moderate (2- to 3-fold) with simvastatin,…”
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Contradictions and Consensus--Clusters of Opinions on E-Books by Shrimplin, Aaron K, Revelle, Andy, Hurst, Susan, Messner, Kevin

“…Q methodology was used to determine attitudes and opinions about e-books among a group of faculty, graduate students, and undergraduates at Miami University of…”
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DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS by WILLIAMS, J. Andrew, HYLAND, Ruth, JONES, Barry C, SMITH, Dennis A, HURST, Susan, GOOSEN, Theunis C, PETERKIN, Vincent, KOUP, Jeffrey R, BALL, Simon E

“…Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs. The objective of this article is to encourage those studying…”
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Guest Editorial: Professionalism's Private Moments by Hurst, Susan M

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A SIGNIFICANT DRUG-METABOLIZING ROLE FOR CYP3A5? by WILLIAMS, J. Andrew, COOK, Jack, HURST, Susan I

“…Recent research on CYP3A5 in vitro and in humans has provided discordant information on whether CYP3A5 plays a significant role in the metabolism of CYP3A…”
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Reaction phenotyping in drug discovery: moving forward with confidence? by Williams, J Andrew, Hurst, Susan I, Bauman, Jonathan, Jones, Barry C, Hyland, Ruth, Gibbs, John P, Obach, R Scott, Ball, Simon E

“…For the pharmaceutical industry, one of the challenges in evaluating the risk of future compound attrition at the discovery stage is the successful prediction…”
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Synthesis and SAR of tolylamine 5-HT6 antagonists by SINGER, Jamie M, WILSON, Michael W, ROUSH, Nicole, CAMPBELL, Jeffrey E, SU, Ti-Zhi, HURST, Susan I, STONER, Chad L, SCHWARZ, Jacob B, JOHNSON, Paul D, GRAHAM, Shelley R, COOKE, Leonard W, ROOF, Robin L, BOXER, Peter A, GOLD, Lisa H, MELTZER, Leonard T, JANSSEN, Ann

“…The synthesis and SAR of tolylamines with 5-HT(6) receptor antagonist activity is presented. The amine, core aromatic, peripheral aromatic, and ether linker…”
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UDP-GLUCURONOSYLTRANSFERASE 2B7 IS THE MAJOR ENZYME RESPONSIBLE FOR GEMCABENE GLUCURONIDATION IN HUMAN LIVER MICROSOMES by BAUMAN, Jonathan N, GOOSEN, Theunis C, TUGNAIT, Meera, PETERKIN, Vincent, HURST, Susan I, MENNING, Lee C, MILAD, Mark, COURT, Michael H, WILLIAMS, J. Andrew

“…The predominant metabolic pathway of gemcabene in humans is glucuronidation. The principal human UDP-glucuronosyltransferases (UGTs) involved in the…”
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A Virtual Standoff – Using Q Methodology to Analyze Virtual Reference by Susan Hurst, Aaron Shrimplin

“…Objective ‐ To develop an exploratory understanding of reference librarians’ perceptions of virtual reference.Methods ‐ Q methodology was used to uncover…”
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