Search Results - "HURLIN, Peter"

MNT and Emerging Concepts of MNT-MYC Antagonism by Yang, Guang, Hurlin, Peter J

“…MYC family proteins play fundamental roles in stem and progenitor cell homeostasis, morphogenesis and cancer. As expected for proteins that profoundly affect…”
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Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma by Hashiguchi, Taylor, Bruss, Nur, Best, Scott, Lam, Vi, Danilova, Olga, Paiva, Cody J, Wolf, Joelle, Gilbert, Erin W, Okada, Craig Y, Kaur, Prabhjot, Drew, Lisa, Cidado, Justin, Hurlin, Peter, Danilov, Alexey V

“…Deregulation of the MYC transcription factor is a key driver in lymphomagenesis. MYC induces global changes in gene expression that contribute to cell growth,…”
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Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes by Zhou, Zi-Qiang, Ota, Sara, Deng, Chuxia, Akiyama, Haruhiko, Hurlin, Peter J

“…Fibroblast growth factor receptor 3 (FGFR3) plays a critical role in the control of endochondral ossification, and bone growth and mutations that cause…”
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The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis by Link, Jason M., Hurlin, Peter J.

“…The MYC family of proteins plays essential roles in embryonic development and in oncogenesis. Efforts over the past 30years to define the transcriptional…”
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Control of vertebrate development by MYC by Hurlin, Peter J

“…The study of MYC has led to pivotal discoveries in cancer biology, induced pluripotency, and transcriptional regulation. In this review, continuing advances in…”
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Mnt modulates Myc-driven lymphomagenesis by Campbell, Kirsteen J, Vandenberg, Cassandra J, Anstee, Natasha S, Hurlin, Peter J, Cory, Suzanne

“…The transcriptional represser Mnt is a functional antagonist of the proto-oncoprotein Myc. Both Mnt and Myc utilise Max as an obligate partner for DNA binding,…”
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The MAX-interacting transcription factor network by Hurlin, Peter J., Huang, Jie

“…The small bHLHZip protein MAX functions at the center of a transcription factor network that governs many aspects of cell behavior, including cell…”
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Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development by Zhou, Zi-Qiang, Shung, Chia-Yi, Ota, Sara, Akiyama, Haruhiko, Keene, Douglas R, Hurlin, Peter J

“…During limb development, chondrocytes and osteoblasts emerge from condensations of limb bud mesenchyme. These cells then proliferate and differentiate in…”
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HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia by Ota, Sara, Zhou, Zi-Qiang, Romero, Megan P, Yang, Guang, Hurlin, Peter J

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HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia by Ota, Sara, Zhou, Zi-Qiang, Romero, Megan P, Yang, Guang, Hurlin, Peter J

“…Mutations that cause increased and/or inappropriate activation of FGFR3 are responsible for a collection of short-limbed chondrodysplasias. These mutations can…”
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Differential Regulation of N-Myc and c-Myc Synthesis, Degradation, and Transcriptional Activity by the Ras/Mitogen-activated Protein Kinase Pathway by Kapeli, Katannya, Hurlin, Peter J.

“…Myc transcription factors are important regulators of proliferation and can promote oncogenesis when deregulated. Deregulated Myc expression in cancers can…”
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Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities by Ota, Sara, Zhou, Zi-Qiang, Hurlin, Peter J

“…Fibroblast growth factor receptor 3 (FGFR3) is amplified, translocated or mutated in a number of different human cancer types, but most commonly in bladder…”
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critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis by Link, Jason M, Ota, Sara, Zhou, Zi-Qiang, Daniel, Colin J, Sears, Rosalie C, Hurlin, Peter J

“…Mnt (Max's next tango) is a Max-interacting transcriptional repressor that can antagonize both the proproliferative and proapoptotic functions of Myc in vitro…”
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Disruption of a Sox9―β-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II by SHUNG, Chia-Yi, OTA, Sara, ZHOU, Zi-Qiang, KEENE, Douglas R, HURLIN, Peter J

“…Mutations in fibroblast growth factor (FGF) receptors are responsible for a variety of skeletal birth defects, but the underlying mechanisms responsible remain…”
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Correction: A novel role of MNT as a negative regulator of REL and the NF-κB pathway by Liaño-Pons, Judit, Lafita-Navarro, M. Carmen, García-Gaipo, Lorena, Colomer, Carlota, Rodríguez, Javier, von Kriegsheim, Alex, Hurlin, Peter J., Ourique, Fabiana, Delgado, M. Dolores, Bigas, Anna, Espinosa, Lluis, León, Javier

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MYC needs MNT by Link, Jason M., Hurlin, Peter J.

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A novel role of MNT as a negative regulator of REL and the NF-κB pathway by Liaño-Pons, Judit, Lafita-Navarro, M. Carmen, García-Gaipo, Lorena, Colomer, Carlota, Rodríguez, Javier, von Kriegsheim, Alex, Hurlin, Peter J., Ourique, Fabiana, Delgado, M. Dolores, Bigas, Anna, Espinosa, Lluis, León, Javier

“…MNT, a transcription factor of the MXD family, is an important modulator of the oncoprotein MYC. Both MNT and MYC are basic-helix–loop–helix proteins that…”
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Of Myc and Mnt by Hooker, C William, Hurlin, Peter J

“…Deregulation of Myc expression is a common feature in cancer and leads to tumor formation in experimental model systems. There are several potential barriers…”
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Activities of N-Myc in the developing limb link control of skeletal size with digit separation by Ota, Sara, Zhou, Zi-Qiang, Keene, Doug R, Knoepfler, Paul, Hurlin, Peter J

“…The developing limb serves as a paradigm for studying pattern formation and morphogenetic cell death. Here, we show that conditional deletion of N-Myc (Mycn)…”
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N-myc functions in transcription and development by Hurlin, Peter J.

“…N‐Myc is a member of the Myc family of proteins, which are best known for their potent oncogenic activities and association with a large proportion of human…”
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