Search Results - "HUREZ, Vincent"

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma by Clark, Curtis A, Gupta, Harshita B, Sareddy, Gangadhara, Pandeswara, Srilakshmi, Lao, Shunhua, Yuan, Bin, Drerup, Justin M, Padron, Alvaro, Conejo-Garcia, José, Murthy, Kruthi, Liu, Yang, Turk, Mary Jo, Thedieck, Kathrin, Hurez, Vincent, Li, Rong, Vadlamudi, Ratna, Curiel, Tyler J

“…PD-L1 antibodies produce efficacious clinical responses in diverse human cancers, but the basis for their effects remains unclear, leaving a gap in the…”
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CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade by Drerup, Justin M, Deng, Yilun, Pandeswara, Sri Lakshmi, Padrón, Álvaro S, Reyes, Ryan M, Zhang, Xinyue, Mendez, Jenny, Liu, Aijie, Clark, Curtis A, Chen, Wanjiao, Conejo-Garcia, José R, Hurez, Vincent, Gupta, Harshita, Curiel, Tyler J

“…The IL2 receptor (IL2R) is an attractive cancer immunotherapy target that controls immunosuppressive T regulatory cells (Treg) and antitumor T cells. Here we…”
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B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses by Lin, Pei-Yi, Sun, Lishi, Thibodeaux, Suzanne R, Ludwig, Sara M, Vadlamudi, Ratna K, Hurez, Vincent J, Bahar, Rumana, Kious, Mark J, Livi, Carolina B, Wall, Shawna R, Chen, Lieping, Zhang, Bin, Shin, Tahiro, Curiel, Tyler J

“…CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a…”
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Age effects of distinct immune checkpoint blockade treatments in a mouse melanoma model by Padrón, Álvaro, Hurez, Vincent, Gupta, Harshita B., Clark, Curtis A., Pandeswara, Sri Lakshmi, Yuan, Bin, Svatek, Robert S., Turk, Mary Jo, Drerup, Justin M., Li, Rong, Curiel, Tyler J.

“…Cancer immunotherapy has shown remarkable recent progress. Immune checkpoint blocking antibodies have become the most successful anti-cancer agent class ever…”
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Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL‐17 producing T cells by Sun, Lishi, Hurez, Vincent J., Thibodeaux, Suzanne R., Kious, Mark J., Liu, Aijie, Lin, Peiyi, Murthy, Kruthi, Pandeswara, Srilakshmi, Shin, Tahiro, Curiel, Tyler J.

“…Summary Regulatory T cells (Tregs) are specialized CD4+ T lymphocytes helping defend against autoimmunity and inflammation. Although age is associated with…”
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Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice by HUREZ, Vincent, DANIEL, Benjamin J, WALL, Shawna, BRUMLIK, Michael J, SHIN, Tahiro, BIN ZHANG, CURIEL, Tyler J, LISHI SUN, LIU, Ai-Jie, LUDWIG, Sara M, KIOUS, Mark J, THIBODEAUX, Suzanne R, PANDESWARA, Srilakshmi, MURTHY, Kruthi, LIVI, Carolina B

“…Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer…”
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Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer by Gupta, Harshita B, Clark, Curtis A, Yuan, Bin, Sareddy, Gangadhara, Pandeswara, Srilakshmi, Padron, Alvaro S, Hurez, Vincent, Conejo-Garcia, José, Vadlamudi, Ratna, Li, Rong, Curiel, Tyler J

“…As tumor PD-L1 provides signals to anti-tumor PD-1 + T cells that blunt their functions, αPD-1 and αPD-L1 antibodies have been developed as anti-cancer…”
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Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment by Liu, Yang, Pandeswara, Srilakshmi, Dao, Vinh, Padrón, Álvaro, Drerup, Justin M, Lao, Shunhua, Liu, Aijie, Hurez, Vincent, Curiel, Tyler J

“…mTOR drives tumor growth but also supports T-cell function, rendering the applications of mTOR inhibitors complex especially in T-cell malignancies. Here, we…”
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Percutaneous BCG enhances innate effector antitumor cytotoxicity during treatment of bladder cancer: a translational clinical trial by Ji, Niannian, Mukherjee, Neelam, Morales, Edwin E., Tomasini, Maggie E., Hurez, Vincent, Curiel, Tyler J., Abate, Getahun, Hoft, Dan F., Zhao, Xiang-Ru, Gelfond, Jon, Maiti, Sourindra, Cooper, Laurence J.N., Svatek, Robert S.

“…Background: Intravesical bacillus Calmette-Guérin (BCG) is the gold standard immunologic agent for treating patients with high-grade non-muscle invasive…”
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Sequential intravesical mitomycin plus Bacillus Calmette-Guérin for non-muscle-invasive urothelial bladder carcinoma: translational and phase I clinical trial by Svatek, Robert S, Zhao, Xiang Ru, Morales, Edwin E, Jha, Mithilesh K, Tseng, Timothy Y, Hugen, Cory M, Hurez, Vincent, Hernandez, Javier, Curiel, Tyler J

“…To determine the safety and toxicities of sequential MMC (mitomycin C) + BCG (bacillus Calmette-Guérin) in patients with non-muscle-invasive bladder cancer…”
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Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors by Gadkar, Kapil, Friedrich, Christina, Hurez, Vincent, Ruiz, Maria‐Luisa, Dickmann, Leslie, Kumar Jolly, Mohit, Schutt, Leah, Jin, Jin, Ware, Joseph A., Ramanujan, Saroja

“…Several PI3K inhibitors are in clinical development for the treatment of various forms of cancers, including pan‐PI3K inhibitors targeting all four PI3K…”
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Immunotherapy for Ovarian Cancer by Drerup, Justin M., Liu, Yang, Padron, Alvaro S., Murthy, Kruthi, Hurez, Vincent, Zhang, Bin, Curiel, Tyler J.

“…Opinion statement All work referenced herein relates to treatment of epithelial ovarian carcinomas, as their treatment differs from ovarian germ cell cancers…”
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Aging‐associated B7‐DC+ B cells enhance anti‐tumor immunity via Th1 and Th17 induction by Tomihara, Kei, Shin, Takako, Hurez, Vincent J., Yagita, Hideo, Pardoll, Drew M., Zhang, Bin, Curiel, Tyler J., Shin, Tahiro

“…Summary Because most patients with cancer are aged and because immunological functions are altered during aging, it is important to account for…”
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Notch2 Haploinsufficiency Results in Diminished B1 B Cells and a Severe Reduction in Marginal Zone B Cells by Witt, Colleen M, Won, Woong-Jai, Hurez, Vincent, Klug, Christopher A

“…Recent studies have implicated a role for Notch in the generation of marginal zone (MZ) B cells. To further investigate the role of Notch in the B cell…”
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Activated Notch2 Potentiates CD8 Lineage Maturation and Promotes the Selective Development of B1 B Cells by Witt, Colleen M., Hurez, Vincent, Swindle, C. Scott, Hamada, Yoshio, Klug, Christopher A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pooled Normal Human Polyspecific IgM Contains Neutralizing Anti-Idiotypes to IgG Autoantibodies of Autoimmune Patients and Protects From Experimental Autoimmune Disease by Hurez, Vincent, Kazatchkine, Michel D., Vassilev, Tchavdar, Ramanathan, Sheela, Pashov, Anastas, Basuyaux, Bertrand, de Kozak, Yvonne, Bellon, Blanche, Kaveri, Srini V.

“…Normal human serum contains IgM antibodies that regulate the natural autoantibody activity of IgG in autologous serum. In the present study, we show that…”
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Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer by Patel, Sukeshi, Hurez, Vincent, Nawrocki, Steffan T, Goros, Martin, Michalek, Joel, Sarantopoulos, John, Curiel, Tyler, Mahalingam, Devalingam

“…Hydroxychloroquine (HCQ) enhances the anti-cancer activity of the histone deacetylase inhibitor, vorinostat (VOR), in pre-clinical models and early phase…”
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Expression and control of the natural autoreactive IgG repertoire in normal human serum by Hurez, V, Kaveri, S V, Kazatchkine, M D

“…We have investigated the autoreactive repertoire expressed by serum IgG of healthy individuals of various age groups using a large panel of self antigens…”
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Considerations for successful cancer immunotherapy in aged hosts by Hurez, Vincent, Padrón, Álvaro, Svatek, Robert S., Curiel, Tyler J.

“…Improvements in understanding cancer immunopathogenesis have now led to unprecedented successes in immunotherapy to treat numerous cancers. Although aging is…”
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Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells by Dao, Vinh, Liu, Yang, Pandeswara, Srilakshmi, Svatek, Robert S, Gelfond, Jonathan A, Liu, Aijie, Hurez, Vincent, Curiel, Tyler J

“…The FDA-approved mTOR inhibitor rapamycin mediates important immune effects, but its contributions to the anticancer effects of the drug are unclear. Here we…”
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